Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods

早期环境对心脏代谢和呼吸系统健康的常见和独特影响：机制和方法

基本信息

批准号：
10475628
负责人：
Emily Oken
金额：
$ 227.74万
依托单位：
HARVARD PILGRIM HEALTH CARE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475628
关键词：
Address Adolescence Adult Age Air Pollution Allergens Area Asthma Attention Back Behavioral Biological Biological Markers Birth Boston Characteristics Chemicals Child Child Health Child Nutrition Childhood Childhood Asthma Chronic Collaborations Complex Conceptions DNA Methylation Data Development Diet Dyspnea Early Intervention Environment Environmental Exposure Environmental Risk Factor Etiology Evolution Exposure to Feedback Fetus Functional disorder Genes Genetic Goals Health Home Hormones Household Individual Intervention Lead Life Longevity Measures Mediation Metals Methods Modernization Modification Mothers Nature Neighborhoods Obesity Outcome Outcome Measure Passive Smoking Pathway interactions Patient Self-Report Persons Pharmaceutical Preparations Phenotype Physical environment Policies Pregnancy Prevention Productivity Quality of life Questionnaires Resolution Respiration Disorders Respiratory Signs and Symptoms Respiratory physiology Risk Risk Factors School-Age Population Science Skin Sleep Social Environment Societies Source Statistical Methods Symptoms System Techniques Teenagers Testing Time Violence Visit airway obstruction cardiometabolism cohort cost dietary early adolescence early childhood early life exposure early pregnancy effective intervention excessive weight gain experience follow-up health care service utilization infancy innovation insight intervention effect maternal depression models and simulation mother nutrition multidisciplinary novel obesity prevention obesity-associated asthma offspring prenatal preventive intervention pulmonary function racism recruit resilience respiratory health response social stressor spatiotemporal tv watching

项目摘要

Project Summary/Abstract Obesity and asthma are the two most common chronic conditions in children. Obesity is a risk factor for asthma as well as for dyspnea not associated with airflow obstruction. Reciprocally, asthma symptoms and some asthma medications may increase risk of excess weight gain. Because no effective cures exist, and because both conditions are often established before school age, early life prevention is critical. Yet our ability to identify the most promising environmental or behavioral targets for prevention has been hampered by the fact that many exposures may be difficult to measure, often overlap and interact, and rarely occur at a single point in time. Individuals may vary in their sensitivity to exposures because of genetic or other factors. Furthermore, obesity and asthma themselves are not static – each may first emerge in early childhood, later childhood, adolescence, or adulthood; once present they may persist, remit, or worsen; and the two outcomes may interact. Sophisticated analytic approaches are needed to handle the complex natures of both longitudinal birth cohort data as well as of the questions themselves. To this end, we propose this project, which is grounded in our large Boston-area Project Viva pre-birth cohort. We recruited mothers in early pregnancy, and have followed them and their children at frequent in-person visits (after delivery and at infancy, early childhood, mid-childhood, and the nearly completed early teen visits) as well as via annual questionnaires. Building on the outcomes we have already assessed from birth through early adolescence, we now propose to characterize adiposity and cardiometabolic health measures as well as lung function and respiratory symptoms into the mid-teen years. Using state of the art statistical methods, we will address the early life environmental exposures that, singly and as mixtures, influence the separate and co-evolution of obesity, asthma and related dysfunctions. We will refine exposure measures, characterize outcome trajectories, and disentangle confounding, mediation and moderation in associations of exposures with outcomes. Finally, we will use agent based simulation models that will draw from but also go beyond the results from our own cohort, to identify optimal levers for effective intervention, incorporating multiple levels of action from physiologogy all the way up to policy. We will contribute the data, measures, and methods we refine within our cohort to the larger ECHO enterprise, as well as findings to be followed up in the large synthetic cohort with its diversity representative of children nationwide.

项目摘要/摘要肥胖和哮喘是儿童最常见的慢性疾病。肥胖是一个危险因素哮喘和呼吸困难与气流异常无关。相互，哮喘符号和某些哮喘药物可能会增加体重增加的风险。因为没有有效的治疗方法，并且由于两种情况通常是在学龄前之前建立的，因此预防早期生活至关重要。但是我们的能力确定最有希望的预防环境或行为目标已受到事实，许多暴露可能难以测量，经常重叠和互动，并且很少发生时间点。由于遗传或其他因素，个人对暴露的敏感性可能会有所不同。此外，肥胖和哮喘本身不是静态的 - 每个人都可能在幼儿时首先出现，以后童年，青少年或成年；一旦出现，它们可能会坚持，屈服或更糟。还有两个结果可能相互作用。需要采用复杂的分析方法来处理这两种纵向的复杂本质生日队列数据以及问题本身。为此，我们提出了这个项目，该项目基于我们的大型波士顿地区Viva Pre-rirth Proth Cohort。我们在怀孕初期招募了母亲，并跟随他们和他们的孩子经常访问（分娩和婴儿期，幼儿，中期和近乎完成的青少年访问）以及通过年度问卷调查。基于我们已经从出生评估到的结果早期的青春期，我们现在建议表征肥胖和心脏代谢健康措施以及肺功能和呼吸道症状到十年中。使用最先进的统计方法，我们将解决新的生活环境暴露，作为混合物，会影响肥胖，哮喘和相关功能障碍的单独和共同进化。我们将完善的暴露措施，表征结果轨迹以及散布混淆，调解和与结果的暴露有关的适度。最后，我们将使用基于代理的仿真模型这将从我们自己的队列中的结果中汲取灵感，以确定最佳杠杆以有效干预措施，从生理学一直纳入政策。我们将我们在队列中还要贡献我们在较大的Echo Enterprise中完善的数据，度量和方法作为在大型合成队列中随后随访的发现，其多样性代表儿童全国。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Maternal diet quality during pregnancy and child cognition and behavior in a US cohort.

DOI：
10.1093/ajcn/nqab325
发表时间：
2022-01-11
期刊：
The American journal of clinical nutrition
影响因子：
0
作者：
Mahmassani HA;Switkowski KM;Scott TM;Johnson EJ;Rifas-Shiman SL;Oken E;Jacques PF
通讯作者：
Jacques PF

Fresh fish findings?

新鲜鱼的发现？