Patient-oriented Research in Maternal Perinatal Overnutrition and Child Adiposity

以患者为中心的母亲围产期营养过剩和儿童肥胖研究

• 批准号: 8843496
• 负责人: Emily Oken
• 金额: $ 16.87万
• 依托单位: HARVARD PILGRIM HEALTH CARE, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-16 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8843496
• 关键词: 11 year old; 3 year old; 7 year old; Animals; Anthropometry; Award; Biological Markers; Birth; Blood Pressure; Body Composition; Body fat; Body mass index; Breast Feeding; Centers for Disease Control and Prevention (U.S.); Child; Child Development; Child Overnutrition; Child health care; Childhood; Cohort Studies; Computerized Medical Record; Consumption; Counseling; Data; Development; Doctor of Philosophy; Enrollment; Exposure to; Fatty Acids; Fatty acid glycerol esters; Fishes; Funding; Gestational Diabetes; Glucose; Glucose Intolerance; Goals; Growth; Health; Health behavior; Hospitals; Human; Hypertension; Influentials; Insulin; Intervention; Investigation; Life; Life Cycle Stages; Lipids; Malnutrition; Maternal Health; Measures; Medicine; Mentors; Mentorship; Mercury; Metabolic; Metabolic Marker; Methods; Mid-Career Clinical Scientist Award (K24); Mothers; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; Obesity; Outcome; Outcome Measure; Overnutrition; Overweight; Pathway interactions; Perinatal; Plasma; Population; Pregnancy Outcome; Prevalence; Prevention; Primary Care Physician; Principal Investigator; Relative (related person); Research; Research Personnel; Risk; Risk Factors; Scanning; System; Time; Training; United States National Institutes of Health; Weight; Weight Gain; Woman; Women' s Health; Work; adipokines; base; cardiometabolic risk; career; disorder risk; experience; fasting glucose; gestational weight gain; glucose tolerance; in utero; innovation; medical schools; metabolomics; mother nutrition; novel; nutrition; offspring; patient oriented; patient oriented research; perinatal health; pregnant; prenatal; professor; randomized trial; research study

DESCRIPTION (provided by applicant): The overall goals of this K24 application are to provide Emily Oken MD, MPH with protected time to serve as a mentor to junior clinician investigators, and to support new scientific aims that will build upon Dr. Oken's established work on the lifecourse health effects of maternal perinatal health and nutrition. Dr. Oken is an Associate Professor in the Department of Population Medicine at Harvard Medical School, and a Primary Care Physician at the Gretchen and Edward Fish Center for Women's Health at Brigham and Women's Hospital. She leads several large patient-oriented research studies, including an NICHD-funded R01 of over 14,000 11-year-old children previously enrolled in a randomized trial of breastfeeding intervention; an ongoing NIEHS-funded R01 of maternal prenatal fish consumption, mercury exposure, and child development at age 7 years; and a CDC-funded project to develop an electronic medical record-based system to support gestational weight gain counseling and tracking. Dr. Oken has already successfully served as a research mentor to more than a dozen clinicians in training and PhD candidates. This K24 award would come at a critical time in Dr. Oken's career, as she solidifies her independent research trajectory and seeks to increase her availability to mentor junior investigators. The award will also support a new research investigation that builds on Dr. Oken's ongoing NIH supported work in maternal perinatal nutrition and offspring health. Early studies on the life course effects of early life nutrition focused on poor growth and under nutrition. More recently, a variety of research findings provide substantive evidence that prenatal over nutrition, including exposure to excesses of maternal weight, gestational glucose, and weight gain, is associated with overweight in offspring. However, extant human studies are limited in that few have included outcome measures other than weight. The proposed scientific aims will take advantage of existing data from Project Viva, a unique US pre-birth cohort study of which Dr. Oken is the co-Principal Investigator, to determine the extent to which maternal weight, gestational weight gain, and gestational glucose tolerance are each associated with adiposity and established measures of cardio- metabolic risk among children at age 7 years. This project will also identify novel metabolic markers in children's plasma at age 7 years, using comprehensive metabolic profiling ("metabolomics"), that are associated with maternal prenatal over nutrition and with child adiposity and standard cardio-metabolic risk factors at the same time point.

描述（由申请人提供）：该K24申请的总体目标是为Emily Oken MD（MPH）提供受保护的时间，以作为初级临床研究人员的导师，并支持Oken博士在母体围产期健康和营养的生命性健康影响的新科学目标。 Oken博士是哈佛医学院人口医学系的副教授，也是Brigham and妇女医院的Gretchen和Edward Fish妇女健康中心的初级保健医生。她领导了几项以患者为导向的大型研究，包括14,000多名11岁儿童的NICHD资助的R01，此前曾参加过一项随机的母乳喂养干预试验；持续的NIEHS资助的R01在7岁时孕产妇的鱼类消费，汞暴露和儿童发育；以及由CDC资助的项目开发基于电子病历的系统，以支持妊娠体重增加的咨询和跟踪。 Oken博士已经成功地担任了十多位培训和博士候选人的临床医生的研究导师。这项K24奖将在Oken博士职业生涯的关键时刻，因为她巩固了自己的独立研究轨迹，并试图增加对导师初级调查人员的可用性。该奖项还将支持一项新的研究调查，该研究基于Oken博士正在进行的NIH支持孕产妇围产期营养和后代健康的工作。早期对早期生活营养影响的早期研究集中在不良生长和营养下。最近，各种研究结果提供了实质性证据，表明营养上的产前产前，包括暴露于产妇体重，妊娠葡萄糖和体重增加的过度，与后代超重有关。但是，现有的人类研究受到限制，因为很少有重量以外的结果指标。拟议的科学目的将利用Viva项目的现有数据，Viva是美国独特的出生前同类研究研究，Oken博士是联合主管研究者，以确定孕产妇体重，体重，妊娠体重增加和妊娠葡萄糖耐受性在多大程度上与肥胖和既定儿童的育儿度量相关的均与7岁以下儿童的儿童相关。该项目还将使用全面的代谢谱分析（“代谢组学”）确定7岁儿童血浆中的新代谢标记，这些标志与营养和儿童肥胖和标准的心脏代谢危险因素在同一时间点上与母体产前有关。

项目成果

Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort (Crete, Greece).

• DOI: 10.1289/ehp.1409062
• 发表时间: 2015-10
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Vafeiadi M;Georgiou V;Chalkiadaki G;Rantakokko P;Kiviranta H;Karachaliou M;Fthenou E;Venihaki M;Sarri K;Vassilaki M;Kyrtopoulos SA;Oken E;Kogevinas M;Chatzi L
• 通讯作者: Chatzi L

Declines in birth weight and fetal growth independent of gestational length.

• DOI: 10.1097/aog.0b013e318278d014
• 发表时间: 2013-01
• 期刊: Obstetrics and gynecology
• 影响因子: 7.2
• 作者: Morisaki N;Esplin MS;Varner MW;Henry E;Oken E
• 通讯作者: Oken E

Screening for obesity in reproductive-aged women.

育龄妇女肥胖筛查。

• 发表时间: 2011
• 期刊: Preventing chronic disease
• 影响因子: 5.5
• 作者: Zera,Chloe;McGirr,Susan;Oken,Emily
• 通讯作者: Oken,Emily

Postpartum screening for diabetes among women with a history of gestational diabetes mellitus.

对有妊娠期糖尿病史的女性进行产后糖尿病筛查。

• 发表时间: 2011
• 期刊: Preventing chronic disease
• 影响因子: 5.5
• 作者: Tovar,Alison;Chasan-Taber,Lisa;Eggleston,Emma;Oken,Emily
• 通讯作者: Oken,Emily

Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood.

• DOI: 10.1016/j.ajog.2014.12.038
• 发表时间: 2015-04
• 期刊: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
• 影响因子: 9.8
• 作者: Karachaliou, Marianna;Georgiou, Vaggelis;Roumeliotaki, Theano;Chalkiadaki, Georgia;Daraki, Vasiliki;Koinaki, Stella;Dermitzaki, Eirini;Sarri, Katerina;Vassilaki, Maria;Kogevinas, Manolis;Oken, Emily;Chatzi, Leda
• 通讯作者: Chatzi, Leda