Planning a Regional Center of Research Excellence in Non-communicable Diseases in India

规划印度非传染性疾病卓越研究区域中心

基本信息

批准号：
9355569
负责人：
Michael Goodman
金额：
$ 24.27万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2019-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9355569
关键词：
Address Anxiety Area Asia Autopsy Bangladesh Basic Science Biological Markers Cancer Center Planning Grant Capital Cardiovascular Diseases Centers of Research Excellence Cessation of life Chronic Disease Cities Clinic Clinical Clinical Sciences Cohort Studies Collaborations Colorectal Cancer Communities Country Data Data Analytics Data Collection Data Linkages Databases Development Diabetes Mellitus Diagnosis Disease Epidemiology Foundations Fright Future Geographic Information Systems Geographic Locations Goals Human Resources Incidence India Individual Institutes Institution International Intervention Interviewer Investigation Joints Knowledge Laboratories Leadership Link Localized Malignant Neoplasm Lung Maintenance Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of gallbladder Medical Mental Depression Mental Health Mentors Methods Modeling Molecular Mouth Neoplasms Needs Assessment Nepal Oral health Outcome Participant Pathway interactions Patient Self-Report Persons Phase Phenotype Population Population Heterogeneity Population Research Positioning Attribute Postdoctoral Fellow Prevalence Prevention Productivity Protocols documentation Public Health Public Health Practice Recording of previous events Registries Research Research Infrastructure Research Personnel Research Priority Research Support Resources Risk Factors Risk Reduction Science Scientist Services Short-Term Course Site Source South Asian Sri Lanka Stroke Time Training United States Universities Upper digestive tract structure Urbanization base biobank cardiometabolic risk clinical research site cohort combat cost effective data management follow-up malignant breast neoplasm malignant mouth neoplasm member modifiable risk multidisciplinary neglect neoplasm registry population based prevent prospective psychosocial response social stigma surveillance study tool triple-negative invasive breast carcinoma tumor

项目摘要

PROJECT SUMMARY The overall goal of this proposal is to leverage existing and new partnerships and infrastructure to develop a unified, country-wide, population- and clinic-based Regional Center for Research Excellence (RCRE) dedicated to the prevention and control of non-communicable diseases (NCDs) in India. The research infrastructure will include three shared core resources (biorespository/laboratory, data management, and field data collection), and research enhancement training to build capacity (basic science fellows, tumor registrars, and research support personnel). These infrastructure components will be applied over time to three demonstration projects. Over the past five years our team has developed four large-scale, well-phenotyped, bio-banked, geographic information systems (GIS)-linked population-based cohorts with data on NCD risk factors and outcomes. Individually, these cohorts are not sufficient in size to evaluate cancer incidence and outcomes, but if combined, these cohorts with over 150,000 person-years of follow-up to-date offer a timely and robust platform to fulfill local cancer and NCD research priorities. The RCRE will be developed in phases by achieving short-, mid- and long- term planning objectives involving different geographic areas. The 2-year short term (Phase I) objective will focus on New Delhi (National Capital Territory) in the north and Chennai (Tamil Nadu State) in the south to efficiently build on our longitudinal Center for Cardiometabolic Risk Reduction in South Asia (CARRS) Surveillance Study cohort and linkable population-based cancer registries located in these two cities. The mid-term (Phase II) objective (2-5 years) is to expand RCRE activities to 2 additional cohorts representing 3 more states with varied levels of urbanization. The long-term (Phase III) objective (5-10 years) will be to expand the RCRE activities nationwide, starting with the 10-site DISHA study, and eventually to other countries of the region, including, but not limited to, Bangladesh, Nepal, and Sri Lanka. The RCRE is co-led by Emory University (HIC), and Public Health Foundation of India (PHFI) and Research Triangle Institute (RTI) India, in partnership with several regional organizations including Madras Diabetes Research Foundation, All India Institute of Medical Sciences (AIIMS), Cancer Institute (WIA), and the Delhi and Chennai Cancer Registries. RCRE activities will be overseen by a Steering Committee, guided by a Scientific Advisory Group, and stimulated by a Community Collaborative Board comprising diverse, NCD-focused global, national- and state-level stakeholders. We focus on three high priority NCDs in India - breast cancer, oral cancer, and diabetes mellitus. Follow completion of the planning phase the research focus will further expand to include other high-burden, emerging or previously neglected NCDs including mental health problems, cardiovascular diseases and stroke, colorectal cancer and cancers of the cervix, gallbladder, upper gastrointestinal tract and lung.

项目概要该提案的总体目标是利用现有和新的合作伙伴关系和基础设施来开发统一的、全国性的、以人口和临床为基础的区域卓越研究中心 (RCRE) 致力于印度非传染性疾病（NCD）的预防和控制。研究基础设施将包括三个共享核心资源（生物储存库/实验室、数据管理和现场数据收集）和研究强化培训以建设能力（基础科学研究人员、肿瘤登记员、和研究支持人员）。这些基础设施组件将随着时间的推移应用到三个示范项目。在过去的五年里，我们的团队开发了四个大规模的、表型良好的、生物库、地理信息系统 (GIS) 相关的基于人群的队列，包含非传染性疾病风险数据因素和结果。就个体而言，这些队列的规模不足以评估癌症发病率和但如果将这些结果结合起来，迄今为止已对超过 150,000 人年进行随访的队列提供了及时的结果以及满足当地癌症和非传染性疾病研究重点的强大平台。 RCRE将分阶段开发通过实现涉及不同地理区域的短期、中期和长期规划目标。 2年期短期（第一阶段）目标将集中在北部的新德里（国家首都地区）和金奈（泰米尔纳德邦）在南部有效地建立我们的纵向心脏代谢风险中心南亚减少 (CARRS) 监测研究队列和可链接的基于人群的癌症登记处位于这两个城市。中期（第二阶段）目标（2-5 年）是将 RCRE 活动扩大到 2 其他队列代表另外 3 个具有不同城市化水平的州。长期（第三阶段）目标（5-10 年）将是在全国范围内扩大 RCRE 活动，从 10 个地点的 DISHA 研究开始，并最终到达该地区的其他国家，包括但不限于孟加拉国、尼泊尔和斯里兰卡。 RCRE 由埃默里大学 (HIC) 和印度公共卫生基金会 (PHFI) 和研究机构共同领导印度三角研究所 (RTI) 与包括马德拉斯糖尿病协会在内的多个区域组织合作研究基金会、全印度医学科学研究所 (AIIMS)、癌症研究所 (WIA) 以及德里和钦奈癌症登记处。 RCRE 活动将由指导委员会监督，并由科学委员会指导咨询小组，并由社区合作委员会推动，该委员会由多元化、以非传染性疾病为重点的全球、国家和州级利益相关者。我们重点关注印度的三种高度优先的非传染性疾病 - 乳腺癌、口腔癌癌症和糖尿病。规划阶段完成后，研究重点将进一步扩大包括其他高负担、新出现或以前被忽视的非传染性疾病，包括精神健康问题，心血管疾病和中风、结直肠癌和子宫颈癌、胆囊癌、上消化道癌胃肠道和肺。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Feasibility of investigating the association between bacterial pathogens and oral leukoplakia in low and middle income countries: A population-based pilot study in India.

DOI：
10.1371/journal.pone.0251017
发表时间：
2021
期刊：
PloS one
影响因子：
3.7
作者：
Shridhar K;Aggarwal A;Rawal I;Gupta R;Masih S;Mehrotra R;Gillespie TW;Dhillon PK;Michaud DS;Prabhakaran D;Goodman M
通讯作者：
Goodman M

A research agenda for non-communicable disease prevention and control in India.