Opioid Use and Acute Suicide Risk: The Real-Time Influence of Trauma Context"

阿片类药物的使用和急性自杀风险：创伤背景的实时影响”

• 批准号: 10674342
• 负责人: Alexa Raudales
• 金额: $ 4.23万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-22 至 2025-05-21
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674342
• 关键词: Acute; Address; Adult; Anxiety; Area; Attention; Behavior; Behavioral; Cessation of life; Communities; Coupled; Distal; Ecological momentary assessment; Environment; Ethics; Feasibility Studies; Feeling suicidal; Funding; Future; Goals; Grant; Health; Impulsivity; Individual; Institution; Intervention; Knowledge; Link; Literature; Measures; Mentors; Mentorship; Methodology; Methods; Modeling; Myopia; National Institute of Drug Abuse; Nature; Numbness; Opioid; Outcome; Overdose; Pattern; Persons; Pharmaceutical Preparations; Phase; Policies; Population; Positioning Attribute; Prevalence; Prevention; Process; Protocols documentation; Psyche structure; Public Health; Recording of previous events; Reporting; Research; Rhode Island; Risk; Risk Factors; Role; Sampling; Self Destructive Behavior; Specific qualifier value; Statistical Models; Suicide; Surveys; Technology; Time; Training; Trauma; Typology; United States; United States National Institutes of Health; Universities; Work; adaptive intervention; associated symptom; cognitive interview; common symptom; comorbidity; coping; craving; death anxiety; design; dysphoria; evidence base; experience; follow-up; high risk; high risk population; individualized medicine; innovation; longitudinal design; multilevel analysis; novel; opioid epidemic; opioid overdose; opioid use; post-traumatic symptoms; premature; psychosocial; public health priorities; recruit; risk sharing; suicidal; suicidal behavior; suicidal risk; suicide rate; tenure track; trauma exposure

Project Summary/Abstract The ongoing opioid epidemic is among the worst public health crises in United States history, with over 200 people dying daily from opioid overdose. Opioid use and suicide co-occur at an alarmingly high rate, and despite large-scale efforts, this rate of co-occurrence continues to escalate. Moreover, the co-occurrence of opioid use and suicide is associated with a wide array of deleterious outcomes, most notably pre-mature death. Consistent with recent NIDA initiatives, co-occurring opioid use and suicide is receiving growing attention as an increasingly urgent public health priority. However, empirical examinations in this area continue to lag behind, with no studies explicating the real-time longitudinal associations between opioid use and acute suicide risk; this information is needed to inform targeted intervention and policy. Furthermore, it remains unknown how an individualized trauma context—notably, proximal posttraumatic stress symptoms (PTSS)—may serve as a trigger for co-occurring opioid use and acute suicide risk. Understanding the momentary associations among PTSS, opioid use, and acute suicide risk is necessary for targeted and timely interventions for co-occurring opioid use and acute suicide risk. This study addresses a critical gap in knowledge by using an ecological momentary assessment (EMA) approach among 60 trauma-exposed adults who currently use opioids and report suicidal thoughts and behaviors (STBs). Specifically, this project will use a novel intensive longitudinal design to examine the unique influence of trauma context on immediate (acute) risk for co-occurring opioid use and suicide risk. This project is significant in that the knowledge to be gained via ecologically valid EMA will specify proximal and context-dependent risk for co-occurring opioid use and suicidality to advance intervention efforts among this vulnerable trauma-exposed population. It is innovative because it utilizes a cutting-edge EMA methodology and advanced quantitative methods to delineate the context-dependent nature of the momentary relations among PTSS, opioid use, and suicide risk, with a focus on personalized statistical models (idiographic) that can inform individualized treatment. The goal of this F31 is to train the Applicant for successful independent research using novel intensive longitudinal designs to examine the time-sensitive associations among PTSS, opioid use, acute suicide risk, with the overarching aim of informing mechanistically driven, real-time interventions. Thus, this project will provide the Applicant imperative training and experience in repeated assessment research, sophisticated multi-level analyses, grantsmanship, dissemination of findings, networking, mentoring, and ethics. The research environment at the University of Rhode Island, including office space, technology, and grant support, along with excellent Sponsors and Consultants with expertise in relevant content areas, provide the ideal setting and mentorship to successfully conduct the proposed project.

项目摘要/摘要 正在进行的阿片类药物流行病是美国历史上最严重的公共卫生危机之一，有200多个 人们每天死于阿片类药物过量。阿片类药物使用和自杀以惊人的速度同时发生，并且 尽管大规模努力，但这种共同出现的速度仍在升级。而且， Oopioid使用和自杀与各种有害结果有关，最著名的是成熟的死亡。 与最近的NIDA倡议一致，同时发生的阿片类药物使用和自杀正在受到越来越多的关注 越来越紧迫的公共卫生优先事项。但是，该领域的经验考试继续落后， 没有研究明确说明阿片类药物使用与急性自杀风险之间的实时纵向关联； 需要此信息来告知有针对性的干预和政策。此外，尚不清楚 个性化的创伤环境 - 尤其是创伤后应激症状（PTSS）的近端 - 可能充当 触发阿片类药物使用和急性自杀风险的触发因素。了解瞬间关联 PTSS，OIOID的使用和急性自杀风险对于针对性及时的干预措施是必要的 OOPIOED使用和急性自杀风险。这项研究通过使用生态学解决了知识的关键差距 目前使用阿片类药物和 报告自杀思想和行为（STB）。具体而言，该项目将使用新颖的密集纵向 设计以检查创伤环境对同时使用阿片类药物的立即（急性）风险的独特影响 和自杀风险。该项目很重要，因为通过生态有效的EMA获得的知识将 指定同时使用阿片类药物使用和自杀的近端和上下文依赖性风险 在这种暴露于创伤的人群中的努力。它具有创新性，因为它利用了尖端 EMA方法和高级定量方法描述了上下文依赖性的性质 PTSS，阿片类药物使用和自杀风险之间的瞬时关系，重点是个性化统计模型 （印度）可以为个性化的治疗提供信息。该F31的目标是培训申请人 成功的独立研究使用新型密集纵向设计来检查时间敏感 PTSS之间的关联，阿片类药物使用，急性自杀风险，其总体目的是机械地告知 驱动的实时干预措施。那将为申请人命令培训和经验提供该项目 在反复的评估研究中，进行了复杂的多层次分析，赠款技巧，调查结果传播， 网络，心理和道德。罗德岛大学的研究环境，包括办公室 太空，技术和赠款的支持，以及优秀的赞助商和顾问与相关方面的专家 内容领域，提供理想的环境和心态，以成功地进行拟议的项目。