An implantable chronic 128 channel macro and micro ECoG system with integrated recording, stimulation, and impedance measuring capabilities

植入式慢性 128 通道宏观和微观 ECoG 系统，具有集成记录、刺激和阻抗测量功能

• 批准号: 9085458
• 负责人: Rajmohan Bhandari
• 金额: $ 34.95万
• 依托单位: BLACKROCK MICROSYSTEMS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9085458
• 关键词: Adult; Aluminum Oxide; Amplifiers; Animal Model; Animals; Architecture; Area; Arts; Back; Biocompatible; Blood Vessels; Chronic; Clinical; Clinical Research; Communities; Custom; Data; Development; Devices; Electrodes; Electronics; Electrophysiology (science); Encapsulated; Engineering; Ensure; Epilepsy; Evaluation; Film; Goals; Health; Histology; Human; Implant; In Situ; In Vitro; Life; Link; Location; Longevity; Maps; Measurement; Measures; Mechanics; Modeling; Monitor; Operative Surgical Procedures; Patients; Phase; Platinum; Polychlorinated Biphenyls; Polymers; Printing; Process; Production; Research; Resistance; Resolution; Safety; Sampling; Shapes; Sheep; Shunt Device; Side; Signal Transduction; Silicones; Site; Skin; Snow; Somatosensory Evoked Potentials; Specificity; Subdural space; Surface; System; Systems Integration; Testing; Thick; Time; Titania; Titanium; Translating; Translations; Wireless Technology; absorption; awake; base; clinical practice; cranium; density; design; digital; electric impedance; flexibility; implantable device; implantation; improved; in vitro testing; in vivo; interest; meetings; microsystems; nervous system disorder; novel; parylene; parylene C; patient safety; signal processing; single photon emission computed tomography; tool

 DESCRIPTION (provided by applicant): The objective of this proposal is to design, develop, and validate a commercially viable "human-use" smart 128-channel macro & micro ECoG microsystem with integrated recording, stimulation, and impedance measuring capabilities for epilepsy monitoring. The microsystem comprises of a state-of-art microelectronic signal processing component linked to a macro & micro integrated ECoG grid via a thin, highly flexible, bio- compatible micro-ribbon cable on one end and a single percutaneous flexible-cable ("pigtail") on the other end. The custom multiplexing ASIC electronics is capable of 128-channel recordings at 16-bit resolution and has fast settle capability (for stimulation option) and patient safety circuitry. The component is contained on a printed circuit board and is encapsulated with Parylene-C and Silicone. The encapsulated microelectronic component unit is encased in a titanium case and resides subcutaneously between the skin and the skull. The integrated microsystem would have unique "snow-flake" shape grid design containing alternate rows of macro and micro channels. The phase-I would target a short-term goal of developing, bench testing and validating in adult sheep model the complete implantable ECoG microsystem that can be translated to research and clinical lab in the shortest time frame.

 描述（由适用提供）：该提案的目的是设计，开发和验证商业上可行的“人使用”智能128通道宏观和微型ECOG微型系统，并具有集成的记录，仿真和阻抗测量能力，可测量癫痫监测的能力。微型系统包括一个最先进的微电信信号处理组件，该组件通过一端的薄，高度柔韧，高度兼容的微核心电缆和单一的经皮柔性柔性蛋白（“ Pigtail”）在另一端链接到宏观和微集成的ECOG网格。自定义的多路复用ASIC电子设备能够以16位分辨率进行128通道的录音，并具有快速的沉降功能（用于模拟选项）和患者 安全电路。该组件包含在印刷电路板上，并用parylene-C和硅胶封装。封装的微电子组件单元被包裹在钛情况中，并在皮肤和颅骨之间皮下居住。集成的微型系统将具有独特的“雪花”形状网格设计，其中包含宏观和微通道的替代行。第1阶段将针对成人绵羊模型开发，基准测试和验证的短期目标，该模型完全可植入的ECOG微型系统，可以在最短的时间范围内将其转化为研究和临床实验室。