HIGHLY CUSTOMIZABLE BLACKROCK MICRO MOLDED ARRAYS (BRMMA)

高度可定制的贝莱德微模塑阵列 (BRMMA)

• 批准号: 8453715
• 负责人: Rajmohan Bhandari
• 金额: $ 35万
• 依托单位: BLACKROCK MICROSYSTEMS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8453715
• 关键词: 3-Dimensional; Active Sites; Animal Model; Architecture; Budgets; Characteristics; Communities; Development; Devices; Electrodes; Environment; Glass; Goals; Gold; Laboratories; Laboratory Research; Lead; Location; Marketing; Masks; Mechanics; Michigan; Molds; Neurosciences Research; Polymers; Price; Process; Property; Research; Shapes; Shoes; Silicon; Slice; Solutions; Specific qualifier value; Spectrum Analysis; Surface; Techniques; Technology; Testing; Time; Tissues; Utah; Vertebral column; Work; base; cost; cytotoxicity test; design; electric impedance; flexibility; in vitro testing; in vivo; man; microsystems; novel; public health relevance; relating to nervous system

DESCRIPTION (provided by applicant): In the last two decades though the field of neuroprosthetics has gained tremendous momentum through the development of novel architectures for neural interfaces, however, till date there is no device which can be nomenclatured as the "gold standard" in the field. As a result the research and technology environment at each laboratory is unique and require a high-level of customization and integration. The objective of this application is to devise a "one-in-all technology" that encompasses the assets (such as ultra high aspect ratio, multi- channels, flexible substrate, interconnection etc.) of the silicon (such as the Utah and Michigan array) and polymer based arrays and mitigates their limitations. Most importantly it provides a highly customized and "poor man's solution" to research laboratories. In this application we present a platform technology, called Blackrock Micro Molding Arrays (BRMMA), based on micro molding technique, which enables devolvement of highly customizable and affordable micro devices without compromising the characteristics of the neural probe such as electrical and mechanical properties, reliability, and durability. BRMMA offers highly customized design rules which include surface and penetrating electrodes. It allow the end users for the first time to dictate their own electrode design (specified within the design rules of BRMMA) as per their hypothesis, and choose the number of active channels per shaft, location and material used for active sites, shape and size of the shaft etc. BRMMA developed by Blackrock Microsystems would produce relevant statistical number of devices to test in vitro and in vivo functionality for long term use BRMMA would be marketed to the neuroscience research community by Blackrock Microsystems.

描述（由申请人提供）：在过去的二十年中，尽管神经植物领域通过开发神经接口的新体系结构而获得了巨大的动力，但是到目前为止，还没有可以将其命名为现场的“金标准”的设备。结果，每个实验室的研究和技术环境都是独特的，需要高级的自定义和集成。该应用程序的目的是设计一种“一式技术”，该技术涵盖了硅（例如犹他州和密歇根州阵列）和基于聚合物的阵列的资产（例如超高纵横比，多通道，柔性基板，互连等），并可以减轻其限制。最重要的是，它为研究实验室提供了高度定制的“穷人解决方案”。在此应用程序中，我们提出了一种基于微型成型技术的平台技术，称为BlackRock微型成型阵列（BRMMA），该技术能够在不损害电气和机械性能，可靠性，可靠性和耐用性的神经探针的特征的情况下进行高度可定制且负担得起的微设备的驱散。 BRMMA提供了高度定制的设计规则，其中包括表面和穿透电极。 It allow the end users for the first time to dictate their own electrode design (specified within the design rules of BRMMA) as per their hypothesis, and choose the number of active channels per shaft, location and material used for active sites, shape and size of the shaft etc. BRMMA developed by Blackrock Microsystems would produce relevant statistical number of devices to test in vitro and in vivo functionality for long term use BRMMA would be marketed to the neuroscience research BlackRock Microsystems的社区。