Blood Flow Velocimetry Using Digital Subtraction Angiography

使用数字减影血管造影进行血流速度测量

基本信息

批准号：
9137447
负责人：
BIPIN SINGH
金额：
$ 22.5万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9137447
关键词：
Address Algorithms Aneurysm Area Arteriographies Arteriovenous malformation Back Behavior Biological Blood Blood Flow Velocity Blood Pressure Blood Vessels Blood flow Cardiac Cardiovascular Diseases Cerebrovascular Disorders Cerebrovascular system Characteristics Clinical Code Complex Data Storage and Retrieval Developed Countries Development Diagnosis Diagnostic Diagnostic radiologic examination Digital Subtraction Angiography Disease Dose Economics Ensure Evolution Failure Geometry Goals Health Healthcare Human Human Resources Image Imaging Techniques Investments Knowledge Lead Light Liquid substance Magnetic Resonance Imaging Maps Measurement Measures Mechanical Stress Medical Medical Imaging Methods Mission Monitor Morbidity - disease rate Morphology Nature Noise Operative Surgical Procedures Optics Pathology Patients Penetration Perioperative Personal Satisfaction Phase Photons Physics Physiologic pulse Play Prevention Procedures Reading Research Research Personnel Resolution Risk Roentgen Rays Role Scientist Signal Transduction Son Source Stenosis Stress System Techniques Technology Testing Therapeutic Thick Time Ultrasonography Universities Validation Vascular Diseases Vascular System Velocimetries Work Yang absorption artery occlusion brain arteriovenous malformations cerebrovascular clinical Diagnosis clinical application computer code cost cost effective design detector experience hemodynamics image processing imaging detector imaging system improved in vivo innovation interest knowledge base meetings mortality new technology novel operation particle prevent programs public health relevance shear stress simulation temporal measurement tool treatment planning

项目摘要

DESCRIPTION (provided by applicant): Diseases in the vascular system are still the leading cause of mortality and morbidity in developed countries despite considerable therapeutic progress in recent years. Blood flow velocity provides critical information needed for the diagnosis of vascular diseases, planning of interventional surgery treatment, and monitoring of endovascular treatment of brain arteriovenous malformations. The lack of such flow characteristics prevents understanding the underlying hemodynamics and its correlation with multiple cerebrovascular diseases. Therefore, there is a critical need to obtain precise blood flow velocities in the vascular system, which can be used to estimate the blood pressure, wall shear stress on the arterial wall and other hemodynamic indicators, and aid in diagnosing and treating a host of vascular diseases. Current diagnostic tools suffer from poor accuracy or low spatial and temporal resolutions. To overcome this limitation, we propose to develop an ultrafast, high-resolution X-ray blood flow velocimetry system that will provide quantitative blood velocity maps in the endovascular system. Furthermore, researchers using numerical simulations to understand the hemodynamics desperately seek detailed blood velocity and stress measurements for comparison and validation of their computer codes. The proposed project aims at providing a novel blood flow velocimetry tool using an ultrafast X-ray probing and inexpensive digital subtraction angiography (DSA) that can recover precise velocity distribution inside of the vascular systems especially for complex geometries. The long-term goal of the proposed research is to provide critical blood flow characteristics in vascular systems allowing scientists to predict the formation, evolution and failure risk of vascular pathology such as arteriovenous malformations, arterial occlusions, stenosis, and aneurysms. The proposed technology has a great potential in generating a real-time perioperative assessment of the blood velocity during a DSA routine. The novel technology will enable medical scientists to gain more fundamental knowledge about the nature and behavior of hemodynamics in cerebrovascular systems. The project is highly relevant to NIH's mission because the precise real-time assessment of blood velocities will lead to more educated therapeutic decisions which could save more lives, improve health, and reduce operation cost. The expanded knowledge base will enhance the Nation's economic well-being and ensure a continued high return on the public investment in research.

描述（由申请人提供）：发达国家的死亡率和病态的主要原因，d尤其是相当多的治疗性治疗疾病基础及其与多种脑舒适性疾病的相关性。。内血管系统中的速度图。该术语的目标提供了关键的血流特征，允许科学家预测作为动脉畸形，替代性闭塞，肾上腺素和动脉瘤的形成，血管病理的衰竭风险。 DSA常规期间的血液速度将使医学科学家能够在脑血管系统中获得更多关于血液动力学的自然和行为的知识。生活，改善健康和重新基础，全国对公共研究投资的经济福祉。