Blood Flow Velocimetry Using Digital Subtraction Angiography

使用数字减影血管造影进行血流速度测量

基本信息

批准号：
9763361
负责人：
BIPIN SINGH
金额：
$ 57.25万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763361
关键词：
Address Air Algorithms Aneurysm Animal Testing Animals Area Arteriographies Blood Blood Flow Velocity Blood Pressure Blood capillaries Blood flow Cardiovascular Diseases Cerebrovascular Disorders Characteristics Clinical Complex Contrast Media Data Developed Countries Developing Countries Development Diagnosis Diagnostic Diagnostic radiologic examination Digital Subtraction Angiography Disease Doctor of Medicine Economics Ensure Evaluation Foundations Geometry Goals Gold Health Healthcare Image Image Enhancement Imaging Techniques Individual Intervention Investments Iowa Knowledge Laboratories Legal patent Letters Light Maps Measurement Measures Mechanical Stress Medical Mission Modality Modeling Monitor Morbidity - disease rate Mus Noise Operative Surgical Procedures Patients Personal Satisfaction Phase Physiologic pulse Preparation Prevention Procedures Property Protocols documentation Reporting Research Resolution Roentgen Rays Savings Signal Transduction Site Source Speed Stream System Technology Testing Therapeutic Time Translating Tube United States National Institutes of Health Universities Vascular Diseases Vascular System Velocimetries Water Width Work Yang base blood flow measurement brain arteriovenous malformations charge coupled device camera clinical Diagnosis clinical practice commercialization cost design dynamic system evaluation/testing hemodynamics image processing imager imaging detector improved in vivo in vivo imaging system innovation innovative technologies instrumentation interest knowledge base medical schools metrology mortality novel off-patent operation particle phase 2 designs professor programs sensor shear stress simulation success temporal measurement tool treatment planning

项目摘要

PROJECT SUMMARY Diseases in the vascular system are still the leading cause of mortality and morbidity in developed countries despite considerable therapeutic progress in recent years. Blood flow velocity provides critical information needed for the diagnosis of vascular diseases, planning of interventional surgery treatment, and monitoring of endovascular treatment of brain arteriovenous malformations. The present lack of knowledge of flow characteristics, arising from the limited temporal and spatial resolution and limited accuracies of the current metrology modalities, averts understanding of the underlying hemodynamics and its correlation with multiple cerebrovascular diseases. To address issues with the current instrumentation, we are developing an ultrafast, high-resolution X-ray blood flow velocimetry system that will provide real time in-vivo quantitative blood velocity maps in the endovascular system. The envisioned system utilizes three transformational technologies; 1) an intense, low cost, pulsed X-ray source with pulse widths down to microseconds and inter-pulse durations of tens of microseconds, 2) an ultrafast X-ray imager with high spatial resolution, large active area, and wide dynamic range, and 3) an X-ray to light converter that overcomes the afterglow and hysteresis limitations of the current high resolution sensors. The system will enable inexpensive digital subtraction angiography (DSA) that can recover precise velocity distribution inside of the vascular systems, especially for complex geometries, making it a unique technology that can be immediately translated into clinical practice. The Phase I research has unequivocally demonstrated the feasibility of developing the proposed system for dynamic blood flow measurements through laboratory experimentation and extensive simulation work. A detailed design of the Phase II system has been accomplished and system evaluation plans have been developed. Specifically, during Phase I we have identified six beta test sites where the Phase II system will be evaluated for various medical applications, the data from which will form a firm foundation for the Phase III commercialization. Considering the commercial potential of the innovative technologies we have filed a US patent application based on the work done so far. This project is highly relevant to NIH's mission because the precise real-time assessment of blood velocities will lead to more educated therapeutic decisions which could save more lives, improve health, and reduce operation cost. The expanded knowledge base will enhance the Nation's economic well-being and ensure a continued high return on the public investment in research.

项目摘要血管系统中的疾病仍然是发达国家死亡率和发病率的主要原因尽管近年来有很大的治疗进展。血流速度提供关键信息需要诊断血管疾病，介入手术治疗计划以及监测脑动脉畸形的血管内治疗。目前缺乏流动知识特征是由有限的时间和空间分辨率以及电流的有限精度产生的计量模式，避免对潜在的血液动力学及其与多个的相关性了解脑血管疾病。为了解决当前仪器的问题，我们正在开发超快，高分辨率的X射线血流velocimetry系统将提供实时的体内定量血液速度图血管内系统。设想的系统利用了三种变革技术。 1）强烈，低成本，脉冲X射线源，其脉冲宽度向下至微秒和脉冲间持续时间微秒，2）具有高空间分辨率，较大的活动区域和宽动态的超快X射线成像仪范围和3）X射线到光转换器，它克服了电流的余辉和磁滞限制高分辨率传感器。该系统将启用廉价的数字减法血管造影（DSA）恢复血管系统内部的精确速度分布，尤其是对于复杂的几何形状，使其成为可以立即转化为临床实践的独特技术。第一阶段的研究明确证明了开发提出的系统的可行性通过实验室实验和广泛的模拟工作，用于动态血流测量。一个已经完成了II期系统的详细设计，系统评估计划已经发达。具体而言，在第一阶段，我们确定了六个Beta测试站点，其中II期系统将是评估各种医疗应用，这些数据将构成第三阶段的牢固基础商业化。考虑到我们已提交的创新技术的商业潜力根据到目前为止所做的工作，专利申请。该项目与NIH的使命高度相关，因为对血液进行了精确的实时评估速度将导致更受过教育的治疗决定，从而可以挽救更多的生命，改善健康和降低操作成本。扩大的知识基础将增强国家的经济福祉，并确保公众对研究的持续高回报。