Microneedle-based Transdermal Sensing of Electrolytes: Towards A Metabolic Panel-

基于微针的电解质透皮传感：迈向代谢组 -

• 批准号: 8881174
• 负责人: JOSEPH WANG
• 金额: $ 30万
• 依托单位: BIOLINQ INCORPORATED
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8881174
• 关键词: 3-Dimensional; 3D Print; Address; Adoption; Archives; Bicarbonate Ion; Bicarbonate Ions; Bicarbonates; Binding; Biological Markers; Biosensor; Blood; Chemicals; Chemistry; Chloride Ion; Chronic; Chronic Disease; Clinical; Data; Deposition; Detection; Development; Devices; Diabetes Mellitus; Eating; Electrochemistry; Electrodes; Electrolyte Balance; Electrolytes; Electrons; Elements; Evaluation; Exhibits; Feedback; Film; Fluid Balance; General Population; Health; Health Personnel; Health care facility; Healthcare; Hepatic; Hospitals; Human; Hypertension; Immobilization; Individual; Ionophores; Ions; Kidney; Kidney Diseases; Laboratories; Liquid substance; Measurement; Measures; Medical; Membrane; Metabolic; Methods; Microelectrodes; Monitor; Nursing Staff; Outcome; Outcomes Research; Pain; Pain-Free; Patients; Performance; Pharmaceutical Preparations; Physical activity; Physiological; Polymers; Potassium Chloride; Price; Primary Health Care; Printing; Process; Renal function; Research; Research Infrastructure; Research Project Grants; Sampling; Serum; Skin; Sleep; Sodium; Staging; Surface; System; Techniques; Time; Training; Transducers; Venipunctures; Visit; Wireless Technology; base; cost; design; effective therapy; follow-up; healthy lifestyle; improved; innovation; member; minimally invasive; novel; potassium ion; response; screening; sensor; sodium ion; trend

DESCRIPTION (provided by applicant): The metabolic panel has emerged as the standard line of inquiry for initial screening as well as follow-up assessment in the healthcare domain. Administered via blood draw in the clinical setting, the metabolic panel consists of assessing 14 unique blood-borne analytes indicative of renal and hepatic function, electrolyte and fluid balance, diabetes mellitus, kidney disease, and hypertension. Despite the clinical utility of the metabolic panel, the process of drawing blood is inconvenient, painful, and can only provide a snapshot of the patient's metabolic function at a particular moment in time, thereby limiting its utility for monitoring chronic conditions. However, in order to be effective, treatment of chronic conditions entails a concerted and proactive effort to manage healthcare throughout the daily routine, which would be substantially enhanced if circulating metabolite and electrolyte levels were able to be quantified on a continuous (rather than intermittent) basis. This project aims to address the above limitations of a conventional metabolic panel via the development of a "Metabolic-Panel-on-A-Chip". The proposed device leverages our team's latest innovations in electrochemistry, 3D-printing, conducting polymers, and surface functionalization to tender the real-time profile of blood-based electrolytes in a minimally-invasive, pain-free fashion, thereby leading to substantially improved clinical outcomes among the general population as well as those afflicted with chronic disease. Expected outcomes from this research project include: (1) the development of minimally-invasive microneedle arrays containing electrochemical transducers that exhibit chemical selectivity towards sodium, potassium, chloride, and bicarbonate ions and (2) the ability to fabricate the said microneedle arrays employing high-throughput, low- cost 3D-printing methods. This agglomerates innovative techniques for the functionalization of the microneedle contingents and relies on the development of ion-selective membranes in connection with novel methods of electrochemical transduction. The salient features of this transdermal biosensor platform include high sensitivity, stability, selectivity, simplicity, versatility, and robustness at a price that is amenable to widespread healthcare adoption. The proposed microneedle array biosensor will thus fill a long-standing void by enabling the healthcare provider to record, archive, and assess the metabolic response of the patient to the administration of various medical treatments, medications, and therapies, resulting in improved management of chronic disease.

描述（由申请人提供）：代谢小组已成为医疗保健领域初始筛查和后续评估的标准询问线。代谢小组在临床环境中通过抽血进行管理，包括评估 14 种独特的血源性分析物，这些分析物指示肾和肝功能、电解质和体液平衡、糖尿病、肾病和高血压。尽管代谢组具有临床实用性，但抽血的过程不方便、痛苦，并且只能及时提供患者代谢功能在特定时刻的快照，从而限制了其监测慢性病的效用。然而，为了有效，慢性病的治疗需要在整个日常生活中协调一致、积极主动地管理医疗保健，如果能够连续（而不是间歇性）量化循环代谢物和电解质水平，这将大大增强基础。该项目旨在通过开发“代谢面板芯片”来解决传统代谢面板的上述局限性。拟议的设备利用我们团队在电化学、3D 打印、导电聚合物和表面功能化方面的最新创新，以微创、无痛的方式提供血液电解质的实时分布，从而显着改善临床一般人群以及慢性病患者的结果。该研究项目的预期成果包括：(1) 开发含有电化学传感器的微创微针阵列，该传感器对钠、钾、氯和碳酸氢根离子表现出化学选择性；(2) 能够采用高强度制造所述微针阵列。 -高通量、低成本的 3D 打印方法。这聚集了微针功能化的创新技术，并依赖于离子选择性膜的开发以及电化学转导的新方法。该透皮生物传感器平台的显着特点包括高灵敏度、稳定性、选择性、简单性、多功能性和稳健性，且价格适合广泛的医疗保健采用。因此，所提出的微针阵列生物传感器将填补长期的空白，使医疗保健提供者能够记录、存档和评估患者对各种医疗、药物和疗法的代谢反应，从而改善慢性病的管理疾病。