Prenatal Timing of Heavy Metal Exposures from Autistic and Non-Autistic Children

自闭症和非自闭症儿童重金属暴露的产前时机

基本信息

批准号：
8769892
负责人：
Manish Arora
金额：
$ 23.17万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8769892
关键词：
Accounting Address Affect Aluminum Animals Apatites Arsenic Autistic Disorder Binding Biological Biological Markers Cadmium Calcified Calcium Case-Control Studies Chemical Exposure Chemicals Child Childhood Chromium Data Dental Dentin Development Disease Elements Environment Environmental Exposure Environmental Risk Factor Epidemic Epidemiologic Studies Etiology Exposure to Fetus Genes Genetic Health Heavy Metals Human Immune system Investigation Lead Life Literature Manganese Measurement Measures Mercury Metal exposure Metals Methodology Methods Mothers Neurodevelopmental Disorder Nickel Perinatal Perinatal Exposure Play Predisposition Pregnancy Property Recording of previous events Risk Risk Factors Role Sampling Staging Time Tissues Tooth structure Toxic Environmental Substances Toxicant exposure Work analytical method autism spectrum disorder autistic children bone case control critical period deciduous tooth early life exposure fetal in utero longitudinal design mineralization neurodevelopment novel postnatal prenatal prospective public health relevance repository skeletal toxicant

项目摘要

DESCRIPTION (provided by applicant): Little is known about the etiology or risk factors for autism, a disease affecting 1 in 50 children in the U.S. While genetic and environmental factors are thought to act together, the specific mechanisms are not known and the measurement of environmental risk factors during critical periods of neurodevelopment has been lacking. This case-control study seeks to apply a novel dental biomarker of early life metal exposure, including in utero, to identify risk factors for ASD. Beyond looking at exposure intensity, we will be able to identify differences in exposure timing between cases and controls. This will allow us to identify critical windows when exposure, even at low levels, increases the risk of ASD. Using the proposed biomarker, we will directly assess fetal exposure, and will not rely on maternal biomarkers which may only provide an indirect measure of fetal exposure to metals. This work will have substantial impact on epidemiologic investigations of the relation of early life chemical exposures to ASD and other neurodevelopmental disorders as it can be used to objectively reconstruct both exposure intensity and timing.

描述（由申请人提供）：对自闭症的病因或危险因素知之甚少，一种影响美国50名儿童中有1例的疾病，而遗传和环境因素被认为是共同起作用的，具体机制尚不清楚，并且在神经发育的关键时期中对环境风险因素的测量缺乏。这项病例对照研究旨在应用一种新型的早期生命金属暴露牙科标志物，包括在子宫内，以识别ASD的危险因素。除了查看暴露强度，我们还将能够识别病例和对照之间的暴露时间差异。这将使我们能够在曝光（即使在低水平下）增加ASD的风险时识别关键窗口。使用拟议的生物标志物，我们将直接评估胎儿暴露，并且不会依靠母体生物标志物，这可能只提供间接衡量胎儿暴露于金属的量度。这项工作将对早期生活关系的流行病学研究产生重大影响暴露于ASD和其他神经发育障碍，因为它可以客观地重建暴露强度和时机。