Administrative Core

行政核心

• 批准号: 10453434
• 负责人: Manish Arora
• 金额: $ 18.97万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10453434
• 关键词: Address; Age; Analytical Chemistry; Biological; Biological Assay; Biological Markers; Biology; Blinded; Blood; Budgets; Chemical Exposure; Chemicals; Client; Communication; Communities; Computer software; Computing Methodologies; Consultations; Counseling; Data; Data Reporting; Databases; Disease; Doctor of Philosophy; Dose; Educational workshop; Ensure; Environment; Environmental Exposure; Environmental Medicine; Epidemiology; Evaluation; Exposure to; Feedback; Fostering; Freezing; Funding; Future; Genetic study; Goals; Grant; Health; Human; Human Development; Human Resources; Institution; Label; Laboratories; Leadership; Management Information Systems; Measures; Metadata; Methodology; Methods; Mission; National Institute of Environmental Health Sciences; New York; Nutritional; Occupations; Online Systems; Organization administrative structures; Outcome; Parents; Participant; Peer Review; Phase; Phenotype; Play; Prevention; Procedures; Process; Prospective Studies; Protocols documentation; Public Health; Publications; Quality Control; Recommendation; Reporting; Research; Research Design; Research Personnel; Resources; Running; Sampling; Services; Ships; Specific Gravity; Specimen; Statistical Data Interpretation; Strategic vision; Structure; Study Subject; Sum; System; Testing; Time; Toxicology; United States National Institutes of Health; Urine; Vision; Work; arm; base; data centers; data management; design; epigenome-wide association studies; evaporation; experience; gene discovery; gene environment interaction; indexing; medical schools; meetings; metabolomics; operation; outreach; prevent; programs; prospective; quality assurance; skills; social; success; symposium; user-friendly

SUMMARY ADMINISTRATIVE CORE The Administrative Core is the overarching organizational unit and serves as the main communication arm of the Mount Sinai Untargeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC), Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC programs including proficiency testing and common QC pools, technical replicates and blinded duplicates, and methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities as directed by the CC. We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra- Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory information management system (LIMS). We organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability, study subject exposure scenarios, health phenotypes, and requested types of chemicals exposures to be measured. We will then make recommendations that best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the Coordinating Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate with the DC and Client/PI in the interpretation of results, (e.g. how specific gravity or sample evaporation may impact metabolomics measures in urine) and the statistical analysis of exposure/phenotype relationships. We will organize and implement an annual Lab Hub workshop that will engage existing and potential clients in Exposure Biology assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR – the New York Exposome Symposium (November 2 - 3, 2018) which drew 200 scientific participants. We use a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Lab Hub program.

摘要行政核心 行政核心是总体组织部门，是 西奈山（Mount Sinai）未靶向的HHEAR LAB HUB，直接与Hear协调中心（CC）合作 数据中心（DC）和NIH计划人员。我们在QA/QC上与其他实验室进行协作并进行交流 包括熟练度测试和常见QC池，技术重复和盲目的重复项在内的计划，以及 最大程度地减少批处理效果和LAB间可变性的方法，我们的团队在该问题中发挥了关键作用 Chear的第一个赠款周期。我们内部协调以最大化效率，并可以灵活地改变我们的优先级 按照CC的指示。我们组织了每周指导委员会（SC）的枢纽会议，以协调内部 集线器的工作流程，包括收到样品运输，重新标记，跟踪和进入我们的实验室 信息管理系统（LIMS）。我们组织了PI/客户咨询会议，我们在其中审查 用于设计，样本标本可用性，研究主题暴露情景，健康表型的家长研究， 并要求测量的化学物质暴露类型。然后，我们将提出最合适的建议 PI/客户的目标，同时解决可能限制可行性之前的任何科学或技术问题 进行测定分析。我们还跟踪正在进行的工作的进度，并为 协调中心和NIH计划。我们与HEAR数据中心（DC）协调数据报告， 确保我们的数据库正确格式化并包含适当的元数据。我们也合作 通过DC和客户/PI的解释，（例如，特定的重力或样本经济如何 影响尿液中的代谢组学测量值）和暴露/表型关系的统计分析。我们 将组织并实施年度实验室中心研讨会，该研讨会将与现有客户和潜在客户一起参与 暴露生物学测定方法。我们是唯一在Chear下组织此次会议的实验室枢纽 - 纽约宣传小组研讨会（2018年11月2日至3日）吸引了200名科学参与者。我们使用 基于Web的LIM界面，用于通过实验室集线器系统跟踪作业进度并评估QA/QC 分析期间的实时。总而言之，我们1）在实验室中心内部和外部协调通信 与协调中心，数据中心，PI/客户和NIH计划有关； 2）制定程序，协议 和系统检查以确保样品流到正确的资源/核心，并且QA/QC协议为 紧随其后； 3）保持用户友好的LIM，促进样本跟踪，防止不匹配不匹配 在样本和结果之间，并与数据中心的需求集成； 4）提供科学 向PI/客户咨询服务，以最大程度地提高其研究结果的信息和质量； 5）确保 反馈沟通发生在客户和资源/核心之间，并传达此信息 透明地到CC和NIH以及6）确保实验室集线器计划的透明财政管理。