The Neural Basis of Social Knowledge

社会知识的神经基础

基本信息

批准号：
8882175
负责人：
Ingrid R Olson
金额：
$ 36.25万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-15 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8882175
关键词：
Amygdaloid structure Anterior Attitude Behavior Brain Brain region Clinical Cues Databases Diffusion Disease Emotional Emotions Episodic memory Evolution Face Face Processing Feeling Functional Magnetic Resonance Imaging Funding Hearing Heart Hospitalization Human Image Individual Individual Differences Knowledge Language Learning Link Measures Memory Memory impairment Mental disorders Mind Names Output Pattern Persons Play Problem Solving Process Property Relapse Research Role Route Schizophrenia Social Behavior Social Functioning Social Network System Temporal Lobe Testing Variant Voice Work abstracting autism spectrum disorder base behavior test face perception flexibility hedonic high school neuromechanism public health relevance relating to nervous system skills social social cognition social neuroscience social skills success theories transmission process white matter

项目摘要

DESCRIPTION (provided by applicant): Humans are an intrinsically social species. Our advanced socio-emotional skills are thought to underpin our tremendous cultural advances as well as the evolution of language. Our superior social skills are underpinned by an increased proficiency in the identification of, and access to knowledge about other people. Social knowledge is supported by increased specialization in a number of cortical regions involved in face processing as well as higher-level regions involved in linking biographical knowledge as well as motivational value to specific faces. In this renewal of our prior R01, we propose to extend our work on the anterior temporal lobes (ATLs) to examine a more specialized circuit for person knowledge. This circuit involves a region in the ventral ATL (vATL) that when damaged, leads to person memory deficits. The vATL face patch appears to serve as an interface between face perception and person memory, linking perceptual representations of distinct identities with abstract person knowledge. However this region does not act alone. We will use multivariate fMRI as well as structural and functional connectivity analyses to examine the flexible interaction of this region with perceptual systems, episodic memory systems, and hedonic valuation systems. Success in this project will significantly advance our understanding of the basic neural mechanisms that contribute to high-level social processing and will have important clinical implications for disorders that have core social knowledge deficits such as autism spectrum disorder and schizophrenia.

描述（由申请人证明）：我们的先进的社会情感技巧被认为是我们的文化和语言演变的基础。涉及FACE处理的皮质区域与我们先前R01的EWAL联系在一起，涉及焊工级别，我们建议将ORK扩展到前颞叶（ATLS）上人知识的电路。检查灵活的互动具有感知系统，情节记忆系统和享乐评估系统的区域。