Modifying Alcohol Approach Motivations with tDCS and Cognitive Retraining

通过 tDCS 和认知再训练改变饮酒动机

基本信息

批准号：
8445527
负责人：
Eric D Claus
金额：
$ 25.38万
依托单位：
THE MIND RESEARCH NETWORK
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-01 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8445527
关键词：
Addictive Behavior Alcohol consumption Alcohol dependence Alcohols Amygdaloid structure Anterior Attitude Avoidance Learning Behavior Behavior Control Behavioral Brain Cognitive Corpus striatum structure Development Dorsal Double-Blind Method Effectiveness Feeling Image Incentives Individual Inferior frontal gyrus Ingestion Insula of Reil Intervention Investigation Knowledge Lateral Lead Learning Maintenance Measures Methods Motivation Neurobiology Neurons Outcome Pharmacological Treatment Positioning Attribute Prefrontal Cortex Probability Procedures Protocols documentation Research Research Personnel Risk Risk-Taking Role Stimulus Techniques Testing Training Training Technics Translating Uncertainty Ventral Striatum Work addiction alcohol cue alcohol effect alcohol response alcohol use disorder approach behavior cingulate cortex cognitive neuroscience craving drinking drinking behavior high risk interest meetings negative mood neural circuit neuroimaging neuromechanism novel programs psychosocial public health relevance relating to nervous system response social

项目摘要

DESCRIPTION (provided by applicant): Motivation to ingest alcohol is among the most important factors that contributes to the development and maintenance of alcohol use disorders. The neural substrates underlying these approach motivations include ventral and dorsal striatum, anterior cingulate cortex, dorsolateral prefrontal cortex, and insula. Current treatments including both pharmacological and psychosocial interventions, appear to work in part by reducing engagement of neural circuits involved in incentive motivation such as the ventral striatum. Further, a new potential treatment that uses cognitive retraining of implicit approach motivations likely exerts its effects by reducing incentive motivation for alcohol and thus the desire to consume alcohol. Few attempts have been made to explicitly enhance cortical regions involved behavioral control, another manner by which it may be possible to reduce motivational drives to use alcohol. Transcranial direct current stimulation (tDCS) is one method of brain stimulation that is known to increase cortical excitability, and its application can result in redued craving, enhanced behavioral control, and enhanced learning, suggesting that tDCS may be useful for augmenting current treatment approaches. Building on cognitive retraining efforts, we propose to 1) investigate the neural mechanisms associated with approach and avoid motivations towards alcohol in high risk drinkers, and 2) investigate the degree to which application of tDCS can enhance learning during cognitive retraining protocols and subsequently reduce approach related motivations and drinking. To that end, we will first determine the neural correlates of avoidance responses to alcohol related stimuli in high risk drinkers as compared to social drinkers. Following this initial study, we will conduct a double-blind investigation of the effects of full strength or sham tDCS on individuals engaged in an avoid alcohol or sham cognitive retraining program on implicit alcohol approach and avoid motivations and drinking. By examining the effects of tDCS on cognitive retraining of alcohol related motivations, we hope to provide initial evidence of the utility of brain stimulation techniques in treatment for alcohol dependence.

描述（由申请人提供）：摄取酒精的动机是有助于开发和维持酒精使用障碍的最重要因素之一。这些方法动机为基础的神经底物包括腹侧和背侧纹状体，前扣带回皮层，背外侧前额叶皮层和岛状。当前的治疗方法包括药理学和社会心理干预措施，部分原因是减少参与激励动机（例如腹侧纹状体）的神经回路的参与。此外，使用隐式方法的认知重新培训的新潜在治疗方法可能通过减少酒精的激励动机并因此渴望喝酒而产生其影响。很少有尝试明确增强涉及行为控制的皮质区域，这是减少使用酒精的动机驱动器的另一种方式。经颅直流电流刺激（TDC）是一种已知可以提高皮质兴奋性的大脑刺激方法，其应用可能会导致渴望降低，增强的行为控制和增强学习，这表明TDC可能有助于增强当前治疗方法。我们建议以认知能力训练的努力为基础1）研究与方法相关的神经机制，并避免在高风险饮用者中对酒精的动机，以及2）调查TDC的应用在认知重新培训方案中可以增强学习的程度，然后降低方法相关的动机和饮酒。为此，与社交饮酒者相比，我们将首先确定高风险饮酒者对酒精相关刺激的反应的神经相关性。在这项初步研究之后，我们将对全强度或假TDC的影响对从事的饮酒或假认知再培训计划的个人进行双盲研究，并避免动机和饮酒。通过检查TDC对酒精相关动机的认知再培训的影响，我们希望提供有关脑刺激技术在酒精依赖治疗中的实用性的初步证据。