Pilot Studies Program

试点研究计划

• 批准号: 8776230
• 负责人: VICTOR M HESSELBROCK
• 金额: $ 7.49万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8776230
• 关键词: Acute; Affect; Alcohol abuse; Alcohol dependence; Behavior; Behavior Therapy; Capital; Chronic; Clinical; Clinical Research; Collaborations; Connecticut; Consultations; Dermal; Dutasteride; Ensure; Ethics; Etiology; Exercise; Extramural Activities; Feedback; Fibroblasts; Gene Expression; Genes; Goals; Growth; Healthcare Systems; Heavy Drinking; Hospitals; Incubators; Intervention; Joint Commission on Accreditation of Healthcare Organizations; Lead; Mentorship; MicroRNAs; N-Methyl-D-Aspartate Receptors; Neurons; New England; Patients; Pilot Projects; Play; Process Measure; Regulation; Research; Research Personnel; Research Proposals; Resources; Role; Safety; Sampling; Signal Transduction; Surveys; System; Testing; The Jackson Laboratory; alcohol exposure; alcohol research; contingency management; design; hazardous drinking; improved; induced pluripotent stem cell; innovation; interest; medical specialties; meetings; obesity risk; personalized medicine; programs; research facility; response; screening, brief intervention, referral, and treatment; treatment program; university student

The Pilot Studies Program continues to play a crucial role in promoting the UCONN ARC'S vitality and growth. During the past 5 years, several innovative studies including: (1) microRNA regulation of HTR1B gene expression; (2) exercise as a behavioral intervention for hazardous drinking in college students; (3) examining genes that may affect problem drinking and obesity risk; and (4) examining the safety and efficacy of dutasteride as a treatment for heavy drinking were supported. One of these projects inspired a major component of this Center renewal application. Others have led, or are likely to lead, to applications for other types of extramural support. The Pilot Studies Program will continue to be managed by the PI and Executive Committee in consultation with internal and external advisors. Following an open call for proposals, applications will be reviewed to: (1) judge scientific merit; (2) improve the quality of the research through feedback, revision, and mentorship (if needed); (3) create a system whereby resources are allocated fairiy and equitably; and (4) ensure that the research meets ethical standards. Several projects are proposed. The first project will examine dermal fibroblasts, sampled from alcoholdependent and non-dependent subjects that are reprogrammed into induced pluripotent stem (iPS) cells and differentiated into neurons. The goal is to detect changes in NMDA receptor and GABAergic signaling in response to acute and chronic alcohol exposure. A second project will survey the fidelity and acceptance of Contingency Management for alcohol dependence as it is disseminated in clinical settings throughout the VA health care system. The third project will take advantage of the screening, brief intervention and referral to treatment (SBIRT) initiative mandated by JCAHO and CMS for hospitals in New England, including UCHC. This study will develop process measures needed to evaluate the mechanisms of change attributable to factors other than the intervention. Projects proposed for the out years will be designed around new alcohol research collaborations being developed with the Connecticut Department of Corrections, the Jackson Laboratories' personalized medicine research facility now under construction on our campus.

试点研究项目继续在促进 UCONN ARC 的活力和发展方面发挥着至关重要的作用。 生长。过去5年中，多项创新性研究包括：（1）HTR1B的microRNA调控 基因表达； (2)运动作为大学生危险饮酒的行为干预； (3) 检查可能影响饮酒问题和肥胖风险的基因； (4)检查安全性和有效性 支持使用度他雄胺治疗酗酒。其中一个项目启发了一位专业人士 该中心续订申请的组成部分。其他人已经或可能导致其他人的申请 外部支持的类型。试点研究计划将继续由 PI 和执行人员管理 委员会与内部和外部顾问协商。经过公开征集提案后， 申请将被审查以： (1) 判断科学价值； （二）提高研究质量 反馈、修订和指导（如果需要）； （三）建立资源公平配置制度 并公平地； (4) 确保研究符合伦理标准。 提出了几个项目。第一个项目将检查取自酒精依赖者的真皮成纤维细胞 以及被重新编程为诱导多能干细胞 (iPS) 的非依赖性受试者 分化为神经元。目标是检测 NMDA 受体和 GABA 信号传导的变化 对急性和慢性酒精暴露的反应。第二个项目将调查的保真度和接受度 酒精依赖的应急管理，因为它在整个退伍军人管理局的临床环境中传播 医疗保健系统。第三个项目将利用筛选、简短干预和转介 JCAHO 和 CMS 为新英格兰的医院（包括 UCHC）强制实施治疗 (SBIRT) 计划。 这项研究将制定评估变化机制所需的过程措施 干预以外的因素。未来几年提出的项目将围绕新酒精进行设计 与康涅狄格州惩教署、杰克逊监狱开展研究合作 实验室的个性化医学研究设施目前正在我们校园建设中。