THE DMAC STUDY

DMAC 研究

• 批准号: 7607657
• 负责人: VICTOR M HESSELBROCK
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607657
• 关键词: Alcohol dependence; Alcohols; Area; Chronic; Computer Retrieval of Information on Scientific Projects Database; DNA; Data; Epigenetic Process; Funding; Funding Agency; Grant; Institution; Malignant Neoplasms; Metabolism; Methylation; Pattern; Pilot Projects; Play; Request for Applications; Research; Research Personnel; Resources; Role; Source; Thinking; United States National Institutes of Health; alcohol effect; cancer risk; carcinogenesis; multidisciplinary; problem drinker

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Deoxyribonucleic acid (DNA) methylation, which is thought to play an important role in carcinogenesis, is an emerging area of epigenetic research. A recent Request For Applications (RFA) (AA-06-005) from the National Institutes of Health (NIH), to which a multidisciplinary investigative group from UCHC responded (Drs. Bonkovsky, Hesselbrock, Lalande, and Lambrecht) targeted epigenetic effects of alcohol and its metabolism as an important area of research. Alcohol has long been associated with cancer and has recently been associated with increased DNA methylation levels. In this pilot study, we propose to determine whether and how DNA methylation patterns in chronic alcoholics are different from suitable controls. This will be the first step in finding out if DNA methylation patterns are altered in subjects with chronic alcohol dependence and provide important pilot data for later, larger proposals to the NIH and other external funding agencies focused on mechanisms whereby alcohol and its metabolites influence cancer risk and other epigenetic effects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 脱氧核糖核酸（DNA）甲基化被认为在癌变中起重要作用，是表观遗传研究的一个新兴领域。 美国国立卫生研究院（NIH）（NIH）的最新申请（RFA）（AA-06-005），UCHC的多学科调查小组回应了（博士Bonkovsky，Hesselbrock，Hesselbrock，Lalande和Lambrecht），以酒精及其重要领域为目标的表观遗传学作用。 酒精长期以来一直与癌症有关，最近与DNA甲基化水平升高有关。在这项试点研究中，我们建议确定慢性酒精中毒中的DNA甲基化模式与合适的对照中的不同。这将是确定慢性酒精依赖受试者中是否改变了DNA甲基化模式的第一步，并为以后提供重要的试点数据，以供NIH和其他外部资助机构提出更大的建议，这些建议和其他外部资助机构侧重于酒精及其代谢物影响癌症风险和其他表观遗传效应。