THE DMAC STUDY

DMAC 研究

• 批准号: 7607657
• 负责人: VICTOR M HESSELBROCK
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607657
• 关键词: Alcohol dependence; Alcohols; Area; Chronic; Computer Retrieval of Information on Scientific Projects Database; DNA; Data; Epigenetic Process; Funding; Funding Agency; Grant; Institution; Malignant Neoplasms; Metabolism; Methylation; Pattern; Pilot Projects; Play; Request for Applications; Research; Research Personnel; Resources; Role; Source; Thinking; United States National Institutes of Health; alcohol effect; cancer risk; carcinogenesis; multidisciplinary; problem drinker

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Deoxyribonucleic acid (DNA) methylation, which is thought to play an important role in carcinogenesis, is an emerging area of epigenetic research. A recent Request For Applications (RFA) (AA-06-005) from the National Institutes of Health (NIH), to which a multidisciplinary investigative group from UCHC responded (Drs. Bonkovsky, Hesselbrock, Lalande, and Lambrecht) targeted epigenetic effects of alcohol and its metabolism as an important area of research. Alcohol has long been associated with cancer and has recently been associated with increased DNA methylation levels. In this pilot study, we propose to determine whether and how DNA methylation patterns in chronic alcoholics are different from suitable controls. This will be the first step in finding out if DNA methylation patterns are altered in subjects with chronic alcohol dependence and provide important pilot data for later, larger proposals to the NIH and other external funding agencies focused on mechanisms whereby alcohol and its metabolites influence cancer risk and other epigenetic effects.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 脱氧核糖核酸（DNA）甲基化被认为在致癌过程中发挥着重要作用，是表观遗传学研究的一个新兴领域。 美国国立卫生研究院 (NIH) 最近提出了一份申请请求 (RFA) (AA-06-005)，UCHC 的一个多学科研究小组（Bonkovsky、Hesselbrock、Lalande 和 Lambrecht 博士）对此做出了回应，目标是表观遗传效应酒精及其代谢成为一个重要的研究领域。 酒精长期以来一直与癌症有关，最近又与 DNA 甲基化水平升高有关。在这项试点研究中，我们建议确定慢性酗酒者的 DNA 甲基化模式是否以及如何与适当的对照不同。这将是查明慢性酒精依赖受试者的 DNA 甲基化模式是否发生改变的第一步，并为以后向 NIH 和其他外部资助机构提出更大规模的提案提供重要的试点数据，该提案重点关注酒精及其代谢物影响癌症风险的机制和其他表观遗传效应。