Pilot studies

试点研究

• 批准号: 7552541
• 负责人: VICTOR M HESSELBROCK
• 金额: $ 20.56万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7552541
• 关键词: Alcoholism; Alcohols; Applications Grants; Area; Basic Science; Development; Etiology; Family history of; Finasteride; Functional Magnetic Resonance Imaging; Funding; Future; Individual; Moods; Pharmacotherapy; Pilot Projects; Procedures; Publications; Research; Review Committee; Risk; TNFRSF5 gene; United States National Institutes of Health; alcohol abuse therapy; base; interest; medical schools; programs; Alcoholism; Alcohols; Applications Grants; Area; Basic Science; Development; Etiology; Family history of; Finasteride; Functional Magnetic Resonance Imaging; Funding; Future; Individual; Moods; Pharmacotherapy; Pilot Projects; Procedures; Publications; Research; Review Committee; Risk; TNFRSF5 gene; United States National Institutes of Health; alcohol abuse therapy; base; interest; medical schools; programs

DESCRIPTION (provided by applicant): The projects proposed for the Pilot Study Component are thematically consistent with projects previously and currently supported by our Center. For example, the proposed study of the effects of finasteride on alcohol-induced changes in mood is consisteht with our Center's long-standing support of pharmacotherapy studies. In addition, the fMRI study of family history negative and family history positive subjects is consistent with our ongoing studies of individuals "at risk" for alcoholism. The basic science studies proposed by Drs. Gary, Shoemaker, and Levine are consistent with the Center's interest in basic science questions that relate to the etiology or treatment of alcoholism. The Pilot Study Program is managed by the PI and Executive Committee, with advice from the Scientific Advisory Group. Pilot studies are approved for funding on the basis of a competitive review procedure which closely approximates the NIH procedure. It begins with an open call for proposals that is circulated within the ARC and to selected research groups in other areas of the School of Medicine. The ARC Executive Committee reviews each proposal to verify, at first, that it is consistent with the research objectives of the ARC. If the proposal is considered to be meritorious by the Executive Committee, it is forwarded to external reviewers. The likelihood that the proposed pilot study will support the development of a larger R01 proposal, or a future major component of the P50, is considered in combination with the proposal's scientific merit in the final funding decision. The progress to date of ARC-supported pilot studies is outstanding. Support from the pilot studies program during the current 5-year cycle has thus far yielded 11 publications, 15 meeting presentations, and--most significantly--8 grant application submissions. We expect that the group of 5 studies proposed for the next cycle of the ARC will be similarly fruitful.

描述（由申请人提供）：试点研究部分提议的项目是 主题与以前的项目一致，目前得到了我们中心的支持。例如，对非那雄胺对酒精引起的情绪变化的影响的拟议研究与我们中心对药物治疗研究的长期支持一致。此外，对家族史负面和家族史积极对象的功能磁共振成像研究与我们正在进行的对酒精中毒“有风险”的个体的研究一致。 Drs提出的基础科学研究。加里（Gary），鞋匠和莱文（Levine）与该中心对与酒精中毒的病因或治疗有关的基础科学问题的兴趣一致。 试点研究计划由PI和执行委员会管理，并在 科学咨询小组。根据竞争性的审查程序，批准了试点研究的资金，该程序近似于NIH程序。首先，呼吁在弧线内传播的建议和医学院其他领域的精选研究小组。 ARC执行委员会审查了每项建议，以验证它与ARC的研究目标一致。如果该提案被执行委员会认为是有功的，则将其转发给外部审查员。拟议的试点研究的可能性将支持较大的R01提案的开发，或P50的未来主要组成部分，并在最终的资助决定中结合了该提案的科学优点。 弧线支持的试点研究的进展非常出色。到目前为止，在当前5年周期期间的试点研究计划的支持产生了11个出版物，15次会议演讲，最重要的是 - 8赠款申请提交。我们预计，为下一个弧线周期提出的5个研究小组将同样富有成果。