Enabling technologies for ultra-high sensitivity PET scanners (PQ13)

超高灵敏度 PET 扫描仪的支持技术 (PQ13)

• 批准号: 8702118
• 负责人: RAMSEY D. BADAWI
• 金额: $ 49.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702118
• 关键词: Accounting; Address; Architecture; Clinical; Communities; Computer software; Country; Data Set; Development; Devices; Dose; Drug Kinetics; Drug Targeting; Educational workshop; Electronics; Ensure; Facility Accesses; Funding; Goals; Health; Housing; Image; Kinetics; Laboratories; Length; Lesion; Medical; Medical Research; Memory; Methods; Metric; Modeling; Monte Carlo Method; Noise; Performance; Physiological; Positron-Emission Tomography; Public Domains; Research; Research Institute; Research Personnel; Resolution; Signal Transduction; Simulate; Solid; Specific qualifier value; System; Techniques; Technology; Testing; Time; To specify; Variant; Work; base; cost; data acquisition; density; design; detector; drug development; image reconstruction; improved; instrumentation; longitudinal positron emission tomography; meetings; meter; novel strategies; open source; radiotracer; reconstruction; simulation; usability

DESCRIPTION (provided by applicant): The overall goal of this application is to develop enabling technologies for the construction of a very large axial field of view PET scanner with effective performance 100-fold greater than existing systems. Specific Aims: We will (1) use simulations to specify spatial resolution and time of flight capabilities that will achieve 100-fol increase in the square of the pre-whitening signal to noise ratio; (2) Build a dialog with clinical researchers to specify requirements and trade-offs for a useful complete device; (3) Design, fabricate and characterize detectors that meet the performance specified in Aim 1; (4) Develop new factorized, parallelized reconstruction methods that can handle the datasets from the scanner in an efficient and scalable manner; (5) Create accurate simulations of electronics systems capable of supporting the ultra-sensitive PET scanner and model the final design options (6) complete planning and costing for the fabrication of the complete device. Methods: Monte-Carlo simulations will be used to specify scanner requirements. Detectors based on 2 variants of existing scintillator-based approaches will be fabricated and tested. A workshop will be held at which clinical researchers and investigators can discuss design issues relating to the project will be held. Electronics configurations based on the open source OpenPET suite and on designs provided by Toshiba Medical will be accurately simulated in software and their performance in conjunction with the detectors built in Aim 2 tested. The investigators will then finalize a design for the scanner, cost it out and apply for funds to complete the project. In the long term, the scanner will be housed in a National Ultra-sensitive PET Facility and access given to academic and industrial researchers from across the country. Health-relatedness: This application will lay the ground-work for the fabrication of an ultra-high sensitivity PET scanner, which can be used to detect much smaller lesions than is currently possible. In addition it can be used to perform kinetic modeling of physiological parameters across the entire body, which can be used to better characterize pathological conditions. It can be used to perform low-dose longitudinal PET studies. It can also be used to determine drug kinetics and targeting early in the drug development pipeline.

描述（由申请人提供）：本申请的总体目标是开发用于构造非常大的轴向视场 PET 扫描仪的使能技术，其有效性能比现有系统高 100 倍。具体目标：我们将 (1) 使用模拟来指定空间分辨率和飞行时间功能，从而将预白化信噪比的平方提高 100 倍； (2) 与临床建立对话 研究人员指定有用的完整设备的要求和权衡； (3) 设计、制造并表征满足目标 1 中规定的性能的探测器； (4) 开发新的因式分解、并行重建方法，能够以高效且可扩展的方式处理来自扫描仪的数据集； (5) 创建能够支持超灵敏 PET 扫描仪的电子系统的精确模拟，并对最终设计选项进行建模 (6) 完整设备制造的完整规划和成本核算。方法：蒙特卡罗模拟将用于指定扫描仪要求。将制造和测试基于现有闪烁体方法的两种变体的探测器。将举行研讨会，临床研究人员和调查人员可以讨论与该项目相关的设计问题。基于开源 OpenPET 套件和东芝医疗提供的设计的电子配置将在软件中精确模拟，并与 Aim 2 中内置的探测器一起测试其性能。然后，研究人员将最终确定扫描仪的设计，计算成本并申请资金来完成该项目。从长远来看，该扫描仪将安装在国家超灵敏 PET 设施中，并可供全国各地的学术和工业研究人员使用。健康相关性：该应用将为超高灵敏度 PET 扫描仪的制造奠定基础，该扫描仪可用于检测比目前小得多的病变。此外，它还可用于对整个身体的生理参数进行动力学建模，从而更好地表征病理状况。它可用于进行低剂量纵向 PET 研究。它还可用于在药物开发流程的早期确定药物动力学和靶向。

项目成果

Performance assessment of a software-based coincidence processor for the EXPLORER total-body PET scanner.

• DOI: 10.1088/1361-6560/aadd3c
• 发表时间: 2018-09-19
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Leung EK;Judenhofer MS;Cherry SR;Badawi RD
• 通讯作者: Badawi RD

Predicting the timing properties of phosphor-coated scintillators using Monte Carlo light transport simulation.

• DOI: 10.1088/0031-9155/59/8/2023
• 发表时间: 2014-04-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Roncali E;Schmall JP;Viswanath V;Berg E;Cherry SR
• 通讯作者: Cherry SR

Ultra staging to unmask the prescribing of adjuvant therapy in cancer patients: the future opportunity to image micrometastases using total-body 18F-FDG PET scanning.

• DOI: 10.2967/jnumed.113.133892
• 发表时间: 2014-04
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Price PM;Badawi RD;Cherry SR;Jones T
• 通讯作者: Jones T

Parallax error in long-axial field-of-view PET scanners-a simulation study.

• DOI: 10.1088/0031-9155/61/14/5443
• 发表时间: 2016-07-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Schmall JP;Karp JS;Werner M;Surti S
• 通讯作者: Surti S