EXPLORER: Changing the Molecular Imaging Paradigm with Total Body PET

EXPLORER：用全身 PET 改变分子成像范式

基本信息

批准号：
9150516
负责人：
RAMSEY D. BADAWI
金额：
$ 331.42万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-25 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9150516
关键词：
Adolescent Anesthesia procedures Antibodies Arthritis Biochemical Biological Biological Assay Biological Process Biomedical Research Body Image Body part Brain Cells Chronic Disease Clinic Clinical Clinical Research Code Computer Simulation Dana-Farber Cancer Institute Data Development Devices Diabetes Mellitus Diagnostic Diagnostics Research Disease Dose Drug Kinetics Ear Electronics Engineering Ensure Europe Event Funding General Hospitals Health Hospitals Hour Human Human body Image Imaging Techniques Immune system Industry Institution Kinetics Knowledge Label Letters Location Longitudinal Studies Massachusetts Measurement Medical Memorial Sloan-Kettering Cancer Center Mental disorders Metabolic syndrome Methods Micrometastasis Modeling Motion Names Noise Nose Obesity Organ Patients Pediatrics Pennsylvania Performance Pharyngeal structure Physicians Population Positron-Emission Tomography Process Radiation Radioisotopes Research Research Infrastructure Risk Scanning Scientist Services Signal Transduction Site Sorting - Cell Movement Systems Biology Technology Testing Therapeutic Time Tissues Tracer United States National Institutes of Health Universities Vendor Work bioimaging body system clinical practice design detector drug discovery electronic data image reconstruction imaging agent imaging system in vivo innovation insight instrumentation meter molecular imaging nanomolar novel therapeutics professor prototype radiotracer signal processing simulation trafficking uptake

项目摘要

DESCRIPTION (provided by applicant): The key strength of positron emission tomography (PET) is its sensitivity that permits imaging of radiotracers in the sub-nanomolar concentration range. However, less than 1% of the available signal is captured, because only a small axial segment of the body (typically 15-20 cm) is imaged at any one time. This leads to relatively long imaging times and non-negligible radiation doses, which are major limiting factors in the broader application of PET. We have assembled a consortium to develop EXPLORER, the world's first total-body scanner that allows all the tissues and organs to be imaged simultaneously and will provide an effective sensitivity gain of at least a factor of 40 over current clinical PET/CT scanners. This sensitivity gain could be used to acquire 40-fold more signal (a >6-fold increase in signal-to-noise), or to acquire total-body images in 1/40th of the time or at 1/40th of the radiation dose, or to track biomolecules over 7-9 radionuclide half-lives (~16 hours for F-18 tracers, ~30 days for Zr-89 tracers) . This has profoundly transformative implications for the application of PET in both clinical diagnostics and research, for example, (1) the ability to acquire FDG whole- body studies in 15-30 seconds (breathhold-PET), (2) the ability to perform whole-body studies in dose- sensitive applications (e.g. pediatrics, adolescents, longitudinal studies of chronic disease and longitudinal studies of cell trafficking) at doses similar to those received on a round-trip transatlantic flight, and (3) the ability to do rapid kinetic studies and obtain pharmacokinetic data from all organs simultaneously as well as an image-derived input function, facilitating new drug discovery, studies of multi-organ interactions and systems biology. With previous NIH funding we have developed all the necessary building blocks for this scanner, including innovative detectors with time-of-flight and depth-encoding capability (essential for dealing with the parallax problems arising from recording highly oblique data), electronics, a complete in silico simulation of the scanner, and image reconstruction code. In this proposal, we seek to use the knowledge we have gained to build the first total-body PET scanner. The engineering work will be guided by industry leaders, and in parallel, our medical advisory board will ensure the proposed development is consistent with the performance needs for applications across a broad spectrum of disease states. The scanner will be sited at one of four top locations (U Penn, MSKCC, UC Davis or UCSF) that have the infrastructure to take advantage of the transformative opportunity presented by this unprecedented device.

描述（通过应用提供）：正电子发射断层扫描（PET）的关键强度是其敏感性，它允许在亚纳摩尔浓度范围内对放射性示例进行成像。但是，捕获了不到1％的可用信号，因为任何时候都只会成像身体的较小轴向段（通常为15-20厘米）。这导致相对较长的成像时间和不可忽略的辐射剂量，这是PET更广泛应用的主要限制因素。我们已经组建了一个财团来开发Explorer，这是世界上第一个允许所有组织和器官同时成像的全体体型扫描仪，并将提供比当前临床PET/CT扫描仪的有效灵敏度增益至少40倍。这种敏感性增长可用于获得40倍的信号（信号到噪声的增加> 6倍），或在辐射剂量的1/40次或1/40的1/40中获取全身图像，或者在7-9个放射性半衰期（〜16小时）（〜16小时）中追踪生物分子（〜16个小时），〜16小时f-18轨道轨道轨道轨道，zr-89 tracers for 〜89 traces for 〜89 trace）〜89 trace）。 This has profoundly transformative implications for the application of PET in both clinical diagnostics and research, for example, (1) the ability to acquire FDG whole-body studies in 15-30 seconds (breathhold-PET), (2) the ability to perform whole-body studies in dose- sensitive applications (e.g. pediatrics, adolescents, longitudinal studies of chronic disease and longitudinal studies of cell trafficking) at doses similar to those received on a往返跨大西洋飞行，以及（3）进行快速动力学研究的能力并仅仅从所有器官以及图像衍生的输入功能，支持新药物发现，多器官相互作用和系统生物学的研究。通过以前的NIH资金，我们为该扫描仪开发了所有必要的构建块，包括具有飞行时间和深度编码功能的创新探测器（对于处理录制高斜数据引起的帕拉克拉克斯问题至关重要），电子设备，这是扫描仪的计算机模拟和图像结构性构造代码的完整。在此提案中，我们试图利用我们所获得的知识来建立第一个全体宠物扫描仪。工程工作将由行业领导者指导，同时，我们的医疗顾问委员会将确保拟议的发展与各种疾病状态的应用的绩效需求一致。扫描仪将位于具有基础架构的四个顶级位置之一（U Penn，MSKCC，UC Davis或UCSF）之一，以利用这种前所未有的设备提供的变革机会。