Basic applications for total-body PET in oncology

全身 PET 在肿瘤学中的基本应用

• 批准号: 10248438
• 负责人: RAMSEY D. BADAWI
• 金额: $ 61.44万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-12 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10248438
• 关键词: Affect; Attention; Breathing; California; Clinical; Clinical Management; Clinical Oncology; Collaborations; Data; Data Set; Devices; Diagnostic; Diagnostic Imaging; Discipline of Nuclear Medicine; Dose; Enrollment; Equilibrium; Equipment; Fasting; Funding; Goals; Hour; Human; Human body; Image; Injections; Investments; Learning; Lesion; Low Dose Radiation; Lymphoma; Malignant neoplasm of lung; Noise; Oncologist; Oncology; PET/CT scan; Pathology; Patient Care; Patients; Performance; Physicians; Population; Positron-Emission Tomography; Protocols documentation; Radiation therapy; Radiology Specialty; Reporting; Scanning; Signal Transduction; Staging; Technology; Time; Universities; attenuation; cancer imaging; clinical application; clinical practice; cohort; cost effective; fluorodeoxyglucose positron emission tomography; low dose computed tomography; melanoma; meter; radiotracer; recruit; simulation; tumor; uptake

Abstract: The EXPLORER Consortium, through funding via a Transformative R01 and substantial commercial investment, has developed a 2-meter long total body PET scanner. This device has the potential to significantly alter the clinical application of PET through (a) substantial reduction in scan times, (b) substantial improvements in image quality, (c) substantial reduction in administered activity and (d) total-body coverage. This proposal aims to answer the basic questions that this new equipment raises with respect to the current clinical oncology application space: (1) how fast a scan can be performed to obtain standard diagnostic images using total-body PET; (2) whether breath-hold PET is feasible; (3) whether the scanner will support a 25-fold reduction in administered radiotracer activity; (4) whether there is value in delaying imaging to much later time-points after injection than current practice and (5) if the improvements in image quality obtained using standard injected doses and scan times have clinical utility. We will enroll 360 subjects from the clinical oncologic population seen at University of California, Davis; specifically, subjects affected by lung cancer, lymphoma and melanoma referred for PET/CT scan initial staging will be enrolled before starting treatment. We expect that the EXPLORER total-body PET scanner will be able to perform studies of similar diagnostic quality to conventional PET/CT scanners in approximately a minute or using a reduced dose corresponding to 1/25th of the standard dose. In addition we predict that breath-hold examinations will be feasible on EXPLORER. We also predict that very late time point imaging will be feasible on EXPLORER resulting in potential gains in lesion conspicuity. Finally, in collaboration with a team of highly-qualified team with expertise in oncology, radiation therapy, radiology and pathology, we will collect initial data to assess the added value of high-quality EXPLORER scans in oncologic imaging compared to conventional PET/CT scanners.

抽象的： 通过转型R01和大量商业的资金，Explorer联盟通过资金 投资已经开发了一个长2米长的全身PET扫描仪。该设备有可能显着 通过（a）大幅度减少扫描时间的临床应用，（b）大量 图像质量的改善，（c）施用活性和（d）总体覆盖范围的大幅度降低。 该建议旨在回答该新设备有关的基本问题 当前的临床肿瘤学应用空间：（1）可以进行扫描的速度以获取标准诊断 使用全身宠物的图像； （2）呼吸养宠物是否可行； （3）扫描仪是否会支持 施用的放射性示例活性降低了25倍； （4）将成像延迟到太多有价值 注射后以后的时间点要比当前练习，（5）如果获得的图像质量的改进 使用标准注射剂量和扫描时间具有临床实用性。 我们将在加利福尼亚大学戴维斯分校的临床肿瘤学人群中注册360名受试者； 具体而言，受肺癌，淋巴瘤和黑色素瘤影响的受试者参考了PET/CT扫描初始 开始治疗之前，将注册分期。 我们预计探险家全身PET扫描仪将能够进行类似的研究 大约一分钟或减少剂量的常规PET/CT扫描仪的诊断质量 对应于标准剂量的1/25。此外，我们预测呼吸持续检查将是 在资源管理器上可行。我们还预测，在资源管理器上，很晚的时间点成像将是可行的 导致病变明显的潜在增长。最后，与一支合格的团队合作 凭借肿瘤学，放射疗法，放射学和病理学的专业知识，我们将收集初始数据以评估 与常规PET/CT相比 扫描仪。