Emotion Dysregulation and Risky Behavior Among People Who Inject Drugs

注射毒品者的情绪失调和危险行为

• 批准号: 8845401
• 负责人: MARY ELLEN MACKESY-AMITI
• 金额: $ 23.87万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8845401
• 关键词: Acquired Immunodeficiency Syndrome; Address; Affect; Alcohol consumption; Alcohol or Other Drugs use; Area; Behavior; Blood; Borderline Personality Disorder; Car Phone; Characteristics; Chicago; Communities; Complex; Cross-Sectional Studies; Data; Development; Devices; Disease; Drug user; Ecological momentary assessment; Electronics; Emotional; Emotions; Enrollment; Epidemic; Equipment; Event; Goals; HIV; Handheld Computers; Hepatitis C; Hepatitis C virus; Hospitalization; Impulsivity; Injection of therapeutic agent; Intervention; Laboratory Study; Life; Major Depressive Disorder; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Methodology; Methods; Moods; Morbidity - disease rate; Needle Sharing; Participant; Persons; Pharmaceutical Preparations; Preventive Intervention; Reporting; Research; Risk; Risk Behaviors; Risk Factors; Role; Sample Size; Sampling; Shares syringes; Social Network; Symptoms; Testing; Time; Variant; design; emotion dysregulation; emotion regulation; intervention program; meetings; metropolitan; public health relevance; sex risk; transmission process

 DESCRIPTION: Sharing of syringes and other injection equipment among people who inject drugs (PWID) is a significant risk factor for transmission and acquisition of blood-borne diseases including HIV and hepatitis C. A recent study of young PWID in the Chicago metropolitan area found that over 40% used a shared syringe, and over 75% shared other injection equipment in the past six months. This study also found that substance- induced major depression (SIMD) and borderline personality disorder (BPD) were significantly associated with receptive syringe sharing. Emotion dysregulation is a hallmark symptom of BPD, and is implicated in major depressive disorders. These findings point to the possible role of negative affect and emotion regulation difficulties in perpetuating injection risk behavior. Prevention intervention programs for PWID may be able to help address these problems, however further research is needed to elucidate the mechanisms that drive the linkages between negative affect, emotion dysregulation and HIV/HCV risk behavior among young PWID. In order to more fully understand the relationship between emotion dysregulation and HIV/HCV risk behavior, we need to collect data in real-time, in the context of everyday activities. Ecological momentary assessment (EMA) is a method for collecting such data, commonly using a portable electronic device such as a handheld computer or mobile phone. This methodology greatly reduces biases associated with retrospective recall, and can capture the interplay of mood and behavior over time. We will use a stratified random time-sampling design to obtain a representative sample of PWID's emotional state, substance use, and injection behavior over a 2-week period. Baseline assessments will be conducted to evaluate mental health and emotion dysregulation. This study will test the acceptability and feasibility of ecological momentary assessment (EMA) to study mood and behavior in young people who inject drugs (PWID), and will gather preliminary data on emotion regulation, mood, and injection behavior among young PWID in the context of everyday activities. The results of this study will inform the development of a larger study to examine the associations among negative affect, emotion dysregulation, and injection risk behavior in PWID. This research will have implications for intervention practices for PWID with emotion regulation difficulties, to reduce risky injection behavior and to promote entry into treatment for substance use and mental health.

 描述：注射吸毒者 (PWID) 共用注射器和其他注射设备是传播和感染艾滋病毒和丙型肝炎等血源性疾病的一个重要风险因素。最近一项针对芝加哥大都市区年轻注射吸毒者的研究发现，超过 40% 的人在过去六个月内使用共用注射器，超过 75% 的人共用其他注射设备。这项研究还发现，物质诱发的重度抑郁症 (SIMD) 和边缘性人格障碍。 (BPD) 与接受注射器共用显着相关，情绪失调是 BPD 的标志症状，并且与严重抑郁症有关。这些研究结果表明，负面情绪和情绪调节困难在持续注射风险预防干预中可能发挥作用。针对注射吸毒者的计划也许能够帮助解决这些问题，但是需要进一步的研究来阐明驱动年轻注射吸毒者的负面情绪、情绪失调和艾滋病毒/丙型肝炎危险行为之间联系的机制。为了更全面地了解情绪失调与 HIV/HCV 危险行为之间的关系，我们需要在日常活动的背景下实时收集数据，生态瞬时评估（EMA）是收集此类数据的常用方法。使用手持电脑或移动电话等便携式电子设备，这种方法大大减少了与回顾性回忆相关的偏差，并且可以捕获情绪和行为随时间的相互作用，我们将使用分层随机时间采样设计来获得代表性。注射吸毒者样本将进行两周内的情绪状态、物质使用和注射行为基线评估，以评估心理健康和情绪失调。本研究将测试生态瞬时评估（EMA）研究情绪和行为的可接受性和可行性。这项研究的结果将为更大规模的研究的开展提供信息，以检验这些关联。其中包括负面情绪、情绪失调、这项研究将对有情绪调节困难的注射吸毒者的干预实践产生影响，以减少危险的注射行为并促进药物滥用和心理健康的治疗。