Patterns of Changing Risk Behavior in the CIDUS-3 Drug Users Intervention Trial

CIDUS-3 吸毒者干预试验中危险行为变化的模式

基本信息

批准号：
8309943
负责人：
MARY ELLEN MACKESY-AMITI
金额：
$ 11.73万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8309943
关键词：
AIDS prevention AIDS/HIV problem Address Alcohol consumption Attention Attitude Behavior Behavior Therapy Belief Blood Categories Cities Communicable Diseases Control Groups Counseling Cross-Sectional Studies Data Data Analyses Drug usage Drug user Educational Intervention Effectiveness of Interventions Emotional Equipment Growth HIV Hepatitis Hepatitis B Virus Hepatitis C Hepatitis C virus Heterogeneity Individual Infection Injecting drug user Injection of therapeutic agent Intervention Intervention Trial Knowledge Lead Mediating Methods Modeling Morbidity - disease rate Outcome Participant Pattern Persons Population Prevention Prevention strategy Preventive Intervention Probability Psychosocial Factor Public Health Randomized Recommendation Recruitment Activity Research Resources Risk Risk Behaviors Screening procedure Services Sex Behavior Sexual Partners Sexual Transmission Site Subgroup Testing Time Variant arm base behavior change cost design effective intervention follow-up improved instrument intervention effect intervention program mortality novel outreach peer person centered programs response sex risk

项目摘要

DESCRIPTION (provided by applicant): Injection drug use is a serious public health problem, leading to blood-borne infections including HBC, HCV, and HIV. In spite of advances in the prevention of HIV/AIDS and hepatitis, injection drug use continues to contribute to new infections both directly through the sharing of injection equipment, and indirectly through sexual transmission from injection drug users (IDUs) to non-IDU sex partners. Behavioral interventions with IDUs are an important component of a comprehensive HIV prevention strategy. Enhanced interventions with IDUs have shown only modest effects over and above standard interventions. The key to improving interventions with IDUs may lie in understanding variations in responses to these interventions. Latent variable approaches (also known as mixture modeling) can be used to identify subgroups of individuals with similar response patterns. These approaches are often referred to as person-centered, in contrast to the traditional variable-centered approaches. To better understand how HIV prevention interventions influence injecting and sexual behavior of IDUs, we will conduct secondary analyses of data from the Third Collaborative Injection Drug Users Study / Drug Users Intervention Trial (CIDUS-3/DUIT). This study recruited young injection drug users in five U.S. cities to test a novel peer education intervention (PEI) against an attention control on changes in HIV/HCV risk behavior. We will use mixture modeling approaches, including latent class analysis, growth mixture modeling, and latent transition analysis, to analyze program outcomes. Our aim is to identify specific subgroups of IDUs for whom the intervention was most beneficial. Moreover, we seek to identify predictors of group membership which would enable us to assign individuals to the intervention that is most likely to have an impact. The proposed analyses will increase our understanding of the effects of the standard and enhanced interventions on injection and sexual risk behavior, and lead to recommendations for improving intervention efforts with injection drug users. The results may also have wider implications for strategizing prevention interventions with other populations.

描述（由申请人提供）：注射吸毒是一个严重的公共卫生问题，可导致血源性感染，包括 HBC、HCV 和 HIV。尽管在预防艾滋病毒/艾滋病和肝炎方面取得了进展，但注射吸毒仍然会直接通过共用注射设备以及通过注射吸毒者 (IDU) 向非注射吸毒者性伴侣的性传播而间接导致新的感染。对注射吸毒者的行为干预是艾滋病毒综合预防战略的重要组成部分。与标准干预措施相比，对注射吸毒者的强化干预仅显示出适度的效果。改善注射吸毒者干预措施的关键可能在于了解对这些干预措施反应的差异。潜变量方法（也称为混合模型）可用于识别具有相似反应模式的个体亚组。与传统的以变量为中心的方法相反，这些方法通常被称为以人为中心。为了更好地了解艾滋病毒预防干预措施如何影响注射吸毒者的注射和性行为，我们将对第三次合作注射吸毒者研究/吸毒者干预试验（CIDUS-3/DUIT）的数据进行二次分析。这项研究招募了美国五个城市的年轻注射吸毒者，以测试一种新颖的同伴教育干预措施 (PEI)，以针对 HIV/HCV 危险行为变化的注意力控制。我们将使用混合建模方法，包括潜在类别分析、增长混合建模和潜在转变分析，来分析项目结果。我们的目标是确定干预对注射吸毒者最有益的特定亚组。此外，我们寻求确定群体成员资格的预测因素，这将使我们能够将个人分配给最有可能产生影响的干预措施。拟议的分析将加深我们对标准干预措施和强化干预措施对注射和性危险行为影响的理解，并提出改进注射吸毒者干预措施的建议。研究结果还可能对与其他人群制定预防干预策略产生更广泛的影响。