Patterns of Changing Risk Behavior in the CIDUS-3 Drug Users Intervention Trial

CIDUS-3 吸毒者干预试验中危险行为变化的模式

基本信息

批准号：
8470609
负责人：
MARY ELLEN MACKESY-AMITI
金额：
$ 11.04万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8470609
关键词：
AIDS prevention AIDS/HIV problem Address Alcohol consumption Attention Attitude Behavior Behavior Therapy Belief Blood Categories Cities Communicable Diseases Control Groups Counseling Cross-Sectional Studies Data Data Analyses Drug usage Drug user Educational Intervention Effectiveness of Interventions Emotional Equipment Growth HIV Hepatitis Hepatitis B Virus Hepatitis C Hepatitis C virus Heterogeneity Individual Infection Injecting drug user Injection of therapeutic agent Intervention Intervention Trial Knowledge Lead Mediating Methods Modeling Morbidity - disease rate Outcome Participant Pattern Persons Population Prevention Prevention strategy Preventive Intervention Probability Psychosocial Factor Public Health Randomized Recommendation Recruitment Activity Research Resources Risk Risk Behaviors Services Sex Behavior Sexual Partners Sexual Transmission Site Subgroup Testing Time Variant arm base behavior change cost design effective intervention follow-up improved injection drug use instrument intervention effect intervention program mortality novel outreach peer person centered programs response screening sex risk

项目摘要

DESCRIPTION (provided by applicant): Injection drug use is a serious public health problem, leading to blood-borne infections including HBC, HCV, and HIV. In spite of advances in the prevention of HIV/AIDS and hepatitis, injection drug use continues to contribute to new infections both directly through the sharing of injection equipment, and indirectly through sexual transmission from injection drug users (IDUs) to non-IDU sex partners. Behavioral interventions with IDUs are an important component of a comprehensive HIV prevention strategy. Enhanced interventions with IDUs have shown only modest effects over and above standard interventions. The key to improving interventions with IDUs may lie in understanding variations in responses to these interventions. Latent variable approaches (also known as mixture modeling) can be used to identify subgroups of individuals with similar response patterns. These approaches are often referred to as person-centered, in contrast to the traditional variable-centered approaches. To better understand how HIV prevention interventions influence injecting and sexual behavior of IDUs, we will conduct secondary analyses of data from the Third Collaborative Injection Drug Users Study / Drug Users Intervention Trial (CIDUS-3/DUIT). This study recruited young injection drug users in five U.S. cities to test a novel peer education intervention (PEI) against an attention control on changes in HIV/HCV risk behavior. We will use mixture modeling approaches, including latent class analysis, growth mixture modeling, and latent transition analysis, to analyze program outcomes. Our aim is to identify specific subgroups of IDUs for whom the intervention was most beneficial. Moreover, we seek to identify predictors of group membership which would enable us to assign individuals to the intervention that is most likely to have an impact. The proposed analyses will increase our understanding of the effects of the standard and enhanced interventions on injection and sexual risk behavior, and lead to recommendations for improving intervention efforts with injection drug users. The results may also have wider implications for strategizing prevention interventions with other populations.

描述（由申请人提供）：注射毒品使用是一个严重的公共卫生问题，导致血传播感染，包括HBC，HCV和HIV。尽管预防艾滋病毒/艾滋病和肝炎方面取得了进步，但注射药物的使用仍可以通过共享注射设备共享直接导致新的感染，以及通过从注射吸毒者（IDU）向非IDU性伴侣进行性传播。与IDU的行为干预是全面预防HIV策略的重要组成部分。与标准干预措施相比，与IDU的增强干预措施仅显示出适度的效果。改善IDU的干预措施的关键可能在于了解对这些干预措施的响应的变化。潜在变量方法（也称为混合模型）可用于识别具有相似响应模式的个体的亚组。与传统的以可变为中心的方法相比，这些方法通常被称为以人为中心。为了更好地了解艾滋病毒预防干预措施如何影响IDU的注射和性行为，我们将对第三次合作注射药物用户研究 /吸毒者干预试验（Cidus-3 / duit）进行次要分析。这项研究招募了美国五个城市的年轻注射吸毒者，以测试一种新型的同伴教育干预措施（PEI），以防止注意HIV/HCV风险行为的变化。我们将使用混合建模方法，包括潜在类别分析，生长混合物建模和潜在过渡分析，以分析计划的结果。我们的目的是确定干预最有益的IDU的特定亚组。此外，我们试图确定小组成员资格的预测因素，这将使我们能够将个人分配给最有可能产生影响的干预措施。拟议的分析将增加我们对标准和增强干预措施对注射和性风险行为的影响的理解，并提出改善与注射吸毒者的干预工作的建议。结果也可能对制定与其他人群的预防干预措施具有更大的影响。