Small Animal Imaging

小动物成像

• 批准号: 8601833
• 负责人: Kimerly Ann Powell
• 金额: $ 9.45万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8601833
• 关键词: Animal Housing; Animals; Biomedical Research; Canada; Cancer Center Support Grant; Computer software; Data; Data Analyses; Development; Electron Spin Resonance Spectroscopy; Environment; Equipment; Frequencies; Germany; Goals; Home environment; Human Resources; Image; Image Analysis; Imaging technology; Institutes; Instruction; Investigation; Laboratory Animals; Malignant Neoplasms; Mission; Modality; Ohio; Online Systems; Operative Surgical Procedures; PET/CT scan; Phase; Preparation; Process; Protocols documentation; Research; Research Personnel; Resolution; Resource Sharing; Series; Services; Small Animal Imaging Shared Resource; Staging; System; Three-Dimensional Imaging; Time; Training; Ultrasonography; Universities; X-Ray Computed Tomography; animal resource; anticancer research; cost; cost effective; design; imaging modality; instrumentation; member; novel; optical imaging; programs; research study; single photon emission computed tomography; square foot; supercomputer

PROJECT SUMMARY (See instructions): The Small Animal Imaging Shared Resource (SAISR) is a newly developed state-of-the-art imaging facility located in 5300 sq ft. of the Biomedical Research Tower (BRT), home to a majority of CCC members. The SAISR is led by Drs. Periannan Kuppusamy (Director) and Kimeriy Powell (Technical Director) and includes high-resolution small animal imaging equipment, image post-processing hardware and software, technical support personnel, and direct interface to Ohio Supercomputer (OSC) facilities. Animal housing for serial imaging studies is provided by University Laboratory Animal resources and two 100 sq ft suites are available for surgical procedures and animal preparation. The following micro imaging equipment is available within this shared resource: 1) An AVANCE 500 WB NMR Spectrometer and Imaging system (Bruker BioSpin, Germany), 2) A BioSpec 94/30 imaging system (Bruker BioSpin, Germany, 3) An Inveon¿ PET/CT Imaging system (Siemens, Eriangen Germany), 4) An Inveon¿ SPECT/PET/CT Imaging system (Siemens, Eriangen Germany), 5) An X-SPECT¿ SPECT/CT imaging system (Gamma Medica, Northridge, CA, USA), 6) A Vevo 2100 high frequency ultrasound system (VisualSonics, Toronto Canada), and 7) four Electron Paramagnetic Resonance (EPR) imaging systems. The primary mission of the SAISR is to provide high quality micro-imaging data to OSUCCC members at low-cost in an efficient and timely manner. Highly trained and dedicated personnel provide services to allow OSUCCC investigators to perform an imaging experiment from the design to analysis stages. SAISR staff proactively develop new imaging protocols and have implemented a web-based server system where 3D imaging data can be downloaded and interactively viewed by the investigators at their desktops. The development phase of SAISR available imaging modalities have increased from 3 to 7 and the facility has been relocated and expanded to centrally-located space near the CCC's primary vivarium. During the last 12 months the SAISR has provided service to 21 OSUCCC investigators in 5 of 6 OSUCCC Scientific Programs for 47% of the total usage. Three full-time personnel manage and operate the facility, and a comprehensive a year long seminar series has been instituted to educate cancer investigators about small animal imaging and cancer research. Furthermore, we anticipate expansion of this environment with integrated multi-modality optical and ultrasound imaging systems. Collectively, the SAISR leverages outstanding institutional support to provide cutting edge imaging instrumentation and services to support high quality cancer research.

项目摘要（请参阅说明）： 小型动物成像共享资源（SAISR）是一个新开发的最先进的成像设施，位于生物医学研究塔（BRT）的5300平方英尺，是大多数CCC成员所在地。 Saisr由Drs领导。 Periannan Kuppusamy（董事）和Kimeriy Powell（技术总监），包括高分辨率的小动物成像设备，图像后处理硬件和软件，技术支持人员以及与俄亥俄州超级计算机（OSC）设施的直接接口。大学实验室动物资源提供了用于串行成像研究的动物外壳，并提供两个100平方英尺的套房进行外科手术和动物准备。以下微型成像设备是 Available within this shared resource: 1) An AVANCE 500 WB NMR Spectrometer and Imaging system (Bruker BioSpin, Germany), 2) A BioSpec 94/30 imaging system (Bruker BioSpin, Germany, 3) An Investon¿ PET/CT Imaging system (Siemens, Eriangen Germany), 4) An Investon¿ SPECT/PET/CT Imaging system (Siemens, Eriangen Germany), 5) An X-spect�Spect/CT成像系统（伽马医学， 美国加利福尼亚州诺斯里奇），6）VEVO 2100高频超声系统（Visualsonics，多伦多加拿大）和7）四个电子顺磁共振（EPR）成像系统。 SAISR的主要任务是以低成本和及时的方式向OSUCCC成员提供高质量的微成像数据。训练有素且专门的人员提供服务，以允许OSUCCC调查人员到达 从设计到分析阶段执行成像实验。 SAISR员工主动开发了新的成像协议，并实施了基于Web的服务器系统，研究人员可以在其台式机上下载3D成像数据并交互观看。 SAISR可用成像方式的开发阶段已从3增加到7，并且该设施已重新定位，并且 扩展到CCC主要体内的中心位置。在过去的12个月中，SAISR为21位OSUCCC调查人员提供了服务，其中6个OSUCCC科学计划中有47％，占总使用量的47％。三名全职人员管理和运营该设施，并且已经成立了一个综合的一年的半身系列，以教育癌症调查员有关小型动物成像和 癌症研究。此外，我们预计通过集成的多模式光学和超声成像系统会扩展这种环境。 SAISR共同利用了出色的机构支持，以提供最先进的成像工具和服务来支持高质量的癌症研究。