Biostatistics and Data Management Core

生物统计和数据管理核心

• 批准号: 8933037
• 负责人: Andrew Ddungu Kambugu
• 金额: $ 5.3万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-17 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933037
• 关键词: Acquired Immunodeficiency Syndrome; Africa; Africa South of the Sahara; Ally; Anti-Retroviral Agents; Attention; Bioinformatics; Biomedical Research; Biometry; California; Clinical Research; Communicable Diseases; Country; Data; Data Analyses; Data Collection; Development; Discipline; Doctor of Philosophy; Early Diagnosis; Educational process of instructing; Ensure; Epidemiology; Faculty; Foundations; Frequencies; Funding; HIV; HIV Infections; Institutes; Instruction; International; Kaposi Sarcoma; Malignant Neoplasms; Mentors; Methods; Pilot Projects; Prevention; Principal Investigator; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rest; Rural; San Francisco; Scientist; Seasons; Solid; Specialist; Statistical Data Interpretation; System; Techniques; Technology; Training; Training Programs; Translational Research; Treatment outcome; Uganda; Universities; Work; base; career; cohort; cost; data management; design; experience; novel strategies; prospective; randomized trial; skills; statistics; success; treatment strategy

Each of the three Research Projects proposed by the Uganda-UCSF Consortium on Prevention and Early Detection of HIV-associated Cancer involves prospective field-based data collection. Each also features the need for biostatistical analysis. Because the Consortium recognizes the importance of data management and biostatistical analysis to research and wishes to transfer relevant technology and approaches to Africa, it will create one shared and efficient resource core for these purposes. The Data Management and Biostatistical Analysis Core (DMBAC) of the Uganda-UCSF Consortium will have the following specific aims: Aim 1. Provide expertise and a common platform for primary data collection and data management. The DMBAC will leverage the expertise in data management built at the Department of Epidemiology and Biostatistics at UCSF over the past two decades and transfer it to the Infectious Diseases Institute (IDI) in Uganda for the support of our three Research Projects and any pilot projects funded by the Consortium. Aim 2. Offer project-specific biostatistical support both during the planning of new research and during the analysis of ongoing studies as well as specialized biostatistical instruction to our emerging Ugandan principal investigators. By offering assistance from faculty-level biostatisticians who are familiar with the substantive aspects of HIV-associated malignancies, the DMBAC will ensure that the 3 Research Projects and any relevant pilot projects are designed and analyzed using the most appropriate biostatistical strategies. Periodic didactic instruction in specialized analytical techniques will allow the emerging Ugandan scientists to keep abreast with current methods and be conversant with biostatisticians. At the end of the 5-year funding period, the DMBAC will have provided support in data management and biostatistical analysis to each of the three Research Projects and all pilot projects that are borne from the consortium. It will have also transferred relevant technology and skills from specialists at UCSF to colleagues in Uganda. Finally, and equally important, it will have also given the emerging Ugandan principal investigators a critical opportunity to interact with and form professional relationships with some of their most important allies — data managers and biostatisticians. These relationships and the best practices derived from them will give the emerging Uganda scientists the solid foundation they need for rest of their career.

乌干达-UCSF预防和早期检测HIV相关癌症提出的三个研究项目中的每个项目都涉及基于现场的数据收集。每个都需要进行生物统计分析。由于该财团认识到数据管理和生物统计分析对于研究和希望将相关技术和方法转移到非洲的重要性，因此它将为这些目的创建一个共同且有效的资源核心。乌干达-UCSF财团的数据管理和生物统计分析核心（DMBAC）将具有以下具体目标： AIM 1。提供专业知识和主要数据收集和数据管理的常见平台。 DMBAC将利用在过去二十年的流行病学和生物统计学部建立的数据管理专业知识，并将其转移到乌干达的传染病研究所（IDI），以支持我们的三个研究项目和财团资助的任何试点项目。 AIM 2。在计划新研究和正在进行的研究分析期间以及对我们新兴的乌干达首席研究人员进行专门的生物统计学教学期间提供特定项目的生物统计学支持。通过提供熟悉与艾滋病毒相关的恶性肿瘤的实质方面的教师级生物统计学家的帮助，DMBAC将确保使用最合适的生物统计策略对3个研究项目和任何相关的试点项目进行设计和分析。专业分析技术中的定期教学教学将使新兴的乌干达科学家能够与当前的方法保持一致，并与生物统计学家转换。 在5年筹资期结束时，DMBAC将为三个研究项目中的每个项目以及从财团诞生的所有试点项目提供数据管理和生物统计分析的支持。它还将将相关技术和技能从UCSF的专家转移到乌干达的同事。最后，同样重要的是，它也将使新兴的乌干达首席研究人员有一个与他们一些最重要的盟友（数据经理和生物统计学家）互动和建立专业关系的关键机会。这些关系和从它们中得出的最佳实践将为新兴的乌干达科学家带来其余职业所需的坚实基础。