Workshops in Molecular and Cellular Glycoscience

分子和细胞糖科学研讨会

基本信息

批准号：
8666655
负责人：
MICHAEL TIEMEYER
金额：
$ 8.5万
依托单位：
UNIVERSITY OF GEORGIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-01 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8666655
关键词：
Address Analytical Chemistry Area Binding Proteins Biochemical Biological Biological Process Biology Carbohydrates Cell physiology Cell surface Cells Cellular biology Chemicals Chemistry Collaborations Communication Communities Congresses Discipline Drug Formulations Educational workshop Eukaryotic Cell Financial Support Funding Funding Agency Future Genetic Glues Glycobiology Glycolipids Glycoproteins Grant Health Human Immune Investigation Knowledge Mediating Metric Molecular Molecular Biology Nature Online Systems Outcome Pathway interactions Physiological Plant Roots Polysaccharides Post-Translational Protein Processing Process Proteins Quality Control Regulation Reporting Request for Proposals Research Research Infrastructure Research Personnel Scientific Societies Scientist Secure Series Societies Solutions Structural Chemistry Structure Subgroup Suggestion Surface Synthesis Chemistry System experience glycoprotein structure infancy interest meetings migration programs protein folding public health relevance response skills success web site working group

项目摘要

DESCRIPTION (provided by applicant): The glycan (carbohydrate) components of the glycoproteins and glycolipids that adorn the surfaces of all eukaryotic cells, as well as the secreted glycoproteins produced by these cells, interact with glycan binding proteins to mediate cellular processes that include differentiation, activation and migration of immune cells, quality control in protein folding, and regulation of protein composition at the cell surface. Despite the importance of these processes, molecular level descriptions of the regulation of glycan synthesis, the influence of glycans on glycoprotein structure, and the functional responses of cells to protein-glycan interactions remain at their infancy. In part this reflects the significant challenges presented by glycan structural diversity and by the complexity of cellular responses to the varied glycan presentations found at diverse biological interfaces. A key to overcoming these challenges is the cooperation of researchers with skills of sufficient diversity to allow the formulation of comprehensive solutions. This proposal requests funding for a series of workshops (two per year), one general meeting, and a networking infrastructure, that will promote the interaction of researchers with these diverse skills in order to solve challenging problems in glycoscience. The communication network and workshop structure proposed here is built on the successful experience of the Consortium for Functional Glycomics (CFG), an entity funded by a "Glue Grant" for the last ten years, and its pool of now more than 500 participating investigators. The proposed workshops will broaden the scope of glycoscience investigations and facilitate the formation of new research teams to address major issues of importance to human health.

描述（由申请人提供）：装饰所有真核细胞表面的糖蛋白和糖脂的聚糖（碳水化合物）成分，以及这些细胞产生的分泌糖蛋白，与聚糖结合蛋白相互作用，介导包括分化在内的细胞过程、免疫细胞的激活和迁移、蛋白质折叠的质量控制以及细胞表面蛋白质组成的调节。尽管这些过程很重要，但聚糖合成调节、聚糖对糖蛋白结构的影响以及细胞对蛋白质-聚糖相互作用的功能反应的分子水平描述仍处于起步阶段。这在一定程度上反映了重要的聚糖结构多样性以及细胞对不同生物界面上发现的不同聚糖呈现的复杂反应带来的挑战。克服这些挑战的关键是具有足够多样性技能的研究人员的合作，以允许制定综合解决方案。该提案要求为一系列研讨会（每年两次）、一次全体会议和一个网络基础设施提供资金，以促进研究人员与这些不同技能的互动，以解决糖科学中的挑战性问题。这里提出的交流网络和研讨会结构是建立在功能糖组学联盟 (CFG) 的成功经验之上的，该联盟是一个在过去十年中由“Glue Grant”资助的实体，目前拥有 500 多名参与研究人员。拟议的研讨会将扩大糖科学研究的范围，并促进新研究团队的组建，以解决对人类健康重要的重大问题。