Perfusion informed lesion mapping in aphasia

失语症的灌注知情病变标测

• 批准号: 8969525
• 负责人: Tracy Love-Geffen
• 金额: $ 22.5万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8969525
• 关键词: Accounting; Acute; Affect; Algorithms; Aphasia; Area; Behavior; Behavioral; Blood; Blood flow; Brain; Brain region; Cells; Cerebrovascular Circulation; Characteristics; Chronic; Classification Scheme; Cognition; Cognitive; Cognitive deficits; Conflict (Psychology); Data; Destinations; Detection; Distal; Emotional; Family; Functional Magnetic Resonance Imaging; Heterogeneity; Image; Impairment; Individual; Individual Differences; Investigation; Language; Language Disorders; Lead; Lesion; Life; Link; Literature; Long-Term Effects; Maps; Measures; Methods; Molecular; Nature; Necrosis; Neurons; Participant; Patient Selection; Patients; Pattern; Performance; Perfusion; Population; Probability; Procedures; Protocols documentation; Recovery of Function; Reporting; Research; Scanning; Shapes; Site; Source; Speech; Staging; Stroke; Structure; Study Section; Survivors; Symptoms; Time; Tissues; United States; Work; acute stroke; base; blood perfusion; brain behavior; brain tissue; chronic stroke; cognitive function; falls; forging; hypoperfusion; innovation; neural recruitment; neuroimaging; novel; public health relevance; relating to nervous system; theories; time use

 DESCRIPTION (provided by applicant): While a good amount of research has been conducted on brain and behavior impairments in acute stroke survivors, little is known about those who are living with aphasia chronically. That is, the field has yet to understand the long term effects of stroke in terms of brain structure support (viability and functionality) and its lik to observed language impairments. In this exploratory proposal we seek to better understand factors underlying the heterogeneity of this chronic aphasia population by systematically, and with more accuracy, defining areas of the brain that are both structurally and 'functionally' impacted. We defined neural tissue as being functionally impacted if it appears viable, but demonstrates reduced blood flow, or hypoperfusion. Hypoperfused tissue has been linked to impaired cognitive and language abilities in acute aphasia, and, more recently in a scant number of investigations with individuals with chronic aphasia. To accomplish this, we take a novel, cutting edge approach by using newer innovative perfusion mapping protocols which include individual measures of blood transit delay. With this information, we are able to collect optimized perfusion maps to better assess viability of neural tissue in the brain. We approach our work by systematically combining two methods- cytoarchitectonic probability and perfusion-informed (individualized) lesion mapping - to detail site and extent of functional lesions in chronic aphasia while associating the resulting maps to individual language behavior. Our specific aims are to use cytoarchitectonic probability maps to better detail areas of the brain effected by stroke by (1) detailing lesion characteristics by using cytoarchitectonically defined probability maps of the language network; (2) identifying hypoperfused, functional lesions, in chronic aphasia and using individualized blood flow timing to investigate the effects of increase blood delivery time on lesion detection; and (3) examining which method, cytoarchitectonic or perfusion-informed lesion maps, is a better predictor of language impairments.

 描述（由适用提供）：虽然已经对大脑和急性中风存活的行为影响进行了大量研究，但人们对那些长期患有迷毒的人知之甚少。也就是说，该领域尚未了解中风的长期影响，从大脑结构支持（可行性和功能）及其喜欢观察语言障碍的角度。在这项探索性建议中，我们试图通过系统地和更准确的慢性失语症种群的异质性来更好地理解这种慢性失语症的异质性的因素，从而定义了大脑在结构和“功能上”受到影响的大脑领域。我们将神经元组织定义为如果看起来可行，在功能上会受到影响，但表现出降低的血液流动或灌注不足。在急性失语症中的认知能力和语言能力受损，最近与慢性失语症患者进行了大量的调查有关。为此，我们通过使用较新的创新灌注映射方案来采用一种新颖的尖端方法，其中包括单个血液传输延迟的度量。有了这些信息，我们能够收集优化的灌注图，以更好地评估大脑中神经元组织的生存能力。我们通过系统地结合两种方法来处理我们的工作：细胞结构的概率和灌注信息（个性化的）病变映射 - 详细介绍慢性失语症中的功能病变的范围，同时将结果映射与个体语言行为相关联。我们的具体目的是使用细胞结构概率图来更好地详细信息，以通过（1）通过使用细胞结构定义的语言网络的细胞结构定义的概率图来详细介绍病变特征的大脑区域； （2）在慢性失语症中识别置液，功能性病变，并使用个性化的血液流动时间来研究增加血液递送时间对病变检测的影响； （3）检查哪种方法，细胞结构或灌注信息的病变图是语言障碍的更好预测指标。