Maternal and Child Health Benefits from Reducing Household Air Pollution

减少家庭空气污染对孕产妇和儿童健康有益

• 批准号: 8519707
• 负责人: Patricia L Hibberd
• 金额: $ 65.19万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-03 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8519707
• 关键词: Address; Adverse effects; Age; Air; Air Pollution; Area; Asia; Attention; Biological; Biological Markers; Biomass; Birth Weight; Carbon Monoxide; Cessation of life; Child; Child health care; Childhood; Clinical; Clinical Research; Clinical Trials; Commit; Communicable Diseases; Communities; Cotinine; Country; Data; Developing Countries; Development; Diarrhea; Educational workshop; Female; First Pregnancy Trimester; Foundations; Funding; Future; Gases; General Hospitals; Goals; Government; Grant; Growth; Growth and Development function; Guidelines; Health; Health Benefit; Height; Household; Human Resources; India; Indoor Air Quality; International; Knowledge; Lead; Leadership; Low Birth Weight Infant; Massachusetts; Maternal and Child Health; Measures; Medical Research; Mentors; Morbidity - disease rate; National Institute of Child Health and Human Development; Neonatal; Neonatal Mortality; Observational Study; Outcome; Particulate Matter; Perinatal; Perinatal mortality demographics; Petroleum; Pneumonia; Policies; Population; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Principal Investigator; Process; Protocols documentation; Public Health; Public Health Schools; Quality of Care; Randomized Clinical Trials; Research; Research Infrastructure; Resources; Risk; Science; Site; Solid; Tobacco smoke; USAID; Ultrasonography; United States National Institutes of Health; Ursidae Family; Weight; Woman; World Health Organization; abstracting; base; catalyst; cooking; evidence base; experience; falls; implementation science; improved; infant outcome; medical schools; mortality; neonatal sepsis; pollutant; primary outcome; programs; public health relevance; randomized trial; respiratory; secondary outcome; working group

DESCRIPTION (provided by applicant): The consortium between the Massachusetts General Hospital and the Indira Gandhi Government Medical College Nagpur, India, affiliated with Lata Medical Research Foundation, has extensive experience in conducting international multicenter collaborative clinical trials/implementation science research dedicated to improving maternal and child health. Since 2008, the consortium has participated as a Research Unit (RU) in the Global Network (GN) for Women's and Children's Health Research and is applying to continue the productive and successful RU in Nagpur, India. The RU's goal is to continue to develop and implement GN sponsored common protocols that generate evidence and scientific knowledge to sustainably improve outcomes for women and children. The research that the MGH-Nagpur consortium proposes to develop is based on their current GN studies on the adverse effects of Household Air Pollution (HAP) on pregnancy and infant outcomes. Their GN research is focused in this area because 3 billion people (~ half of the world's population) and -80% of pregnant women in the GN still use traditional cook stoves and solid fuels that generate high levels of household pollutants, far exceeding World Health Organization (WHO) indoor air quality guidelines. WHO estimates that HAP causes 2 million deaths annually (mostly in women and children). They propose to develop a multicenter randomized clinical trial to evaluate whether pregnancy and infant outcomes can be improved by introduction of cook stoves/fuel that reduce HAP in households where pregnant women, in their first trimester, are using traditional cook stoves. The primary outcome is birth weight. Secondary outcomes are preterm birth, perinatal/neonatal mortality, childhood pneumonia/neonatal sepsis and adverse child growth/development. They also propose to measure HAP levels in women and children in a random subset of households to improve knowledge about the biological basis of the effects of HAP - including particulate matter < 2.5 micrometers, carbon monoxide and biomarkers 1-hydroxypyrene, methoxyphenol and cotinine (tobacco smoke). Successful introduction of cook stoves/fuel that reduce HAP has the potential to sustainably improve pregnancy outcomes and child health in resource limited settings.

描述（由申请人提供）：马萨诸塞州总医院和印度那格浦尔英迪拉甘地政府医学院组成的联盟，隶属于拉塔医学研究基金会，在开展国际多中心协作临床试验/实施科学研究方面拥有丰富的经验，致力于改善孕产妇的健康状况。和儿童健康。自 2008 年以来，该联盟作为研究单位 (RU) 参与了妇女和儿童健康研究全球网络 (GN)，并正在申请继续在印度那格浦尔开展富有成效和成功的 RU。 RU 的目标是继续制定和实施 GN 赞助的通用协议，以产生证据和科学知识，以可持续地改善妇女和儿童的结果。 MGH-那格浦尔联盟提议开展的研究基于他们目前关于家庭空气污染 (HAP) 对怀孕和婴儿结局的不利影响的 GN 研究。他们的 GN 研究主要集中在这一领域，因为 GN 的 30 亿人（约占世界人口的一半）和 -80% 的孕妇仍然使用传统炉灶和固体燃料，这些燃料会产生高浓度的家庭污染物，远远超过世界卫生组织的排放标准。组织（WHO）室内空气质量指南。世界卫生组织估计，HAP 每年导致 200 万人死亡（主要是妇女和儿童）。他们提议开展一项多中心随机临床试验，以评估在孕妇在妊娠早期使用传统炉灶的家庭中，引入炉灶/燃料以减少 HAP 是否可以改善妊娠和婴儿结局。主要结果是出生体重。次要结局是早产、围产期/新生儿死亡率、儿童肺炎/新生儿败血症和儿童生长/发育不良。他们还建议测量随机家庭子集中妇女和儿童的 HAP 水平，以提高对 HAP 影响的生物学基础的了解 - 包括 < 2.5 微米的颗粒物、一氧化碳和生物标志物 1-羟基芘、甲氧基苯酚和可替宁（烟草）抽烟）。成功引入减少 HAP 的炉灶/燃料有可能在资源有限的环境中持续改善妊娠结局和儿童健康。