Boston University/Lata Medical Research Foundation and Indira Gandhi Government Medical Center Global Network for Women's Children's Health Research Unit

波士顿大学/拉塔医学研究基金会和英迪拉甘地政府医疗中心全球妇女儿童健康网络研究单位

• 批准号: 9754220
• 负责人: Patricia L Hibberd
• 金额: $ 61.6万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-03 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754220
• 关键词: 3 year old; 5 year old; Address; Area; Attention; Bacterial Infections; Boston; Catchment Area; Cessation of life; Child; Child Health; Childhood; Clinical Research; Clinical Trials; Communicable Diseases; Development; Diagnosis; Diarrhea; Discipline of obstetrics; Environmental Exposure; Faculty; Foundations; Funding; Goals; Government; Grant; Growth and Development function; Health; Health trends; Household Air Pollution; India; Infant; Infant Mortality; Institution; International; Intervention; Knowledge; Lead; Life; Live Birth; Malnutrition; Maternal Mortality; Maternal and Child Health; Medical Research; Medical Students; Medical center; Mentors; Mission; Morbidity - disease rate; Mothers; National Institute of Child Health and Human Development; Neonatal Mortality; Neonatology; Newborn Infant; Outcome; Pediatrics; Perinatal Care; Pneumonia; Population; Poverty; Pregnancy; Pregnant Women; Protocols documentation; Publications; Records; Research; Research Infrastructure; Research Personnel; Resources; Risk Factors; Role; Rural; Sanitation; Site; Socioeconomic Status; Testing; Time; Universities; Urban Population; Woman; base; clinical implementation; cost effective; design; disability; early childhood; experience; implementation science; improved; infant morbidity; mHealth; medical schools; mortality; neonatal outcome; neonatal sepsis; novel; nutrition; point of care; public health intervention; public health research; recruit; retention rate

Project Summary/Abstract The Global Network (GN) Research Unit (RU) of Boston University and the Indira Gandhi Government Medical College (IGGMC)/Lata Medical Research Foundation (LMRF) in Nagpur, India are applying to the re- competition of NICHD’s Global Network of Women and Children’s Health Research to continue their participation in GN research mission. Since the Nagpur-based RU in the eastern part of the Indian state of Maharashtra has neonatal and infant mortality rates that are higher than overall rates in India, there is an important need to improve health outcomes of mothers and their infants in the RU catchment area. The RU has extensive experience in leading and conducting international multicenter collaborative clinical trials and implementation science research dedicated to generating evidence on the best ways to improve maternal and child health in its population in need. Additional strengths of the RU include its ability to recruit >10,000 pregnant women/year into GN studies with > 99% retention rates, and mentoring of junior investigators. The goals of the Nagpur RU over the next five years are twofold. The first goal is to continue to participate in multicenter, high impact, cost-effective, large scale clinical studies in populations of women and children that have the highest burden of death and disability globally. The second goal is to augment the mentoring of junior researchers to improve their research capacity and publication records and to support their ability to successfully compete for grants to study important public health interventions. The specific aims of the RU are to: (1) develop strategies to continue the growth and development of the Nagpur RU and to sustain the research infrastructure that supports the design and conduct of public health research in the Nagpur academic institutions; (2) strengthen research focused on the leading causes of morbidity and mortality in pregnancy and early childhood in the GN and in the Nagpur area; (3) provide support to the GN to continue to identify and address gaps in maternal and child research. The Nagpur RU proposes to achieve their goals and specific aims by continuing to collaborate with the GN in conducting scientifically justified and rigorously designed common protocols targeting key gaps in knowledge, relating to improving health outcomes in mothers and their infants in resource-limited settings. The Nagpur RU will continue to contribute scientific expertise to the GN, particularly in areas of specific strength in the Nagpur RU, including pediatrics, neonatology, infectious diseases, (childhood pneumonia/neonatal sepsis/diarrhea), environmental exposures, particularly household air pollution, nutrition/malnutrition, obstetrics and testing of novel mHealth interventions for point-of-care diagnosis of obstetric and pediatric morbidity and complications.

项目概要/摘要 波士顿大学全球网络 (GN) 研究单位 (RU) 和英迪拉·甘地政府医学中心 印度那格浦尔学院 (IGGMC)/拉塔医学研究基金会 (LMRF) 正在申请重新 NICHD 全球妇女和儿童健康研究网络竞赛继续其 自从印度东部那格浦尔的 RU 参与 GN 研究任务以来。 马哈拉施特拉邦的新生儿和婴儿死亡率高于印度的总体死亡率， 迫切需要改善 RU 学区母亲及其婴儿的健康状况。 在领导和开展国际多中心协作临床试验方面拥有丰富的经验 实施科学研究致力于为改善孕产妇和儿童健康的最佳方法提供证据 RU 的其他优势包括其招募超过 10,000 名儿童的能力。 每年孕妇参与 GN 研究，保留率 > 99%，并对初级研究人员进行指导。 那格浦尔大学未来五年的目标有两个：第一个目标是继续参与。 针对妇女和儿童群体进行的多中心、高影响力、具有成本效益的大规模临床研究 全球死亡和残疾负担最重的国家第二个目标是加强对青少年的指导。 研究人员提高他们的研究能力和出版记录，并支持他们的能力 成功竞争资助以研究重要的公共卫生干预措施 RU 的具体目标是。 目的： (1) 制定战略以继续那格浦尔大学的成长和发展，并维持 支持那格浦尔学术界公共卫生研究设计和开展的研究基础设施 (2) 加强对孕产期发病和死亡主要原因的研究 尼泊尔自治区和那格浦尔地区的幼儿教育；(3) 为尼泊尔自治区继续识别和提供支持； 解决孕产妇和儿童研究方面的差距。 那格浦尔 RU 建议通过继续与 GN 合作来实现其目标和具体目标 科学合理并严格执行针对关键知识差距的共同协议， 与改善资源有限环境中母亲及其婴儿的健康状况相关。 将继续为 GN 贡献科学专业知识，特别是在那格浦尔的特定优势领域 RU，包括儿科、新生儿科、传染病（儿童肺炎/新生儿败血症/腹泻）、 环境暴露，特别是家庭空气污染、营养/营养不良、产科和检测 用于产科和儿科发病率和并发症即时诊断的新型移动医疗干预措施。