Taxi Particulate Matter Study (Zhang/Jans)

出租车颗粒物研究（Zhang/Jans）

基本信息

批准号：
8919665
负责人：
KAREN HUBBARD
金额：
$ 11.82万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-26 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8919665
关键词：
Address Admission activity Air Anti-Inflammatory Agents Anti-inflammatory Biochemical Markers Biological Markers Bronchoalveolar Lavage Fluid Carbon Black Carcinogens Cardiopulmonary Chemicals Cities Communities Community Outreach Control Groups Data Diesel Exhaust Education Education and Outreach Epigenetic Process Exhalation Exposure to Genes Health Home environment Hospitals Hour Immigrant Individual Inflammation Inflammatory Intervention Link Malignant Neoplasms Malignant neoplasm of lung Mass Fragmentography Measures Memorial Sloan-Kettering Cancer Center Metals Methods Methylation Monitor New York New York City Nitrates Nitrites Occupational Oxidative Stress Particulate Particulate Matter Physiological Prevalence Prospective Studies Publications Randomized Research Research Training Risk Smoking System Translational Research Work abstracting air filtration anticancer research atmospheric aerosols cancer risk clinical Diagnosis comparison group cost cytokine design high efficiency particulate air filter mortality never smoker peer programs research study respiratory screening shift work trafficking volatile organic compound

项目摘要

Abstract There are approximately 240,000 U.S. taxi/limousine drivers in the U.S.(1). New York City (NYC) is home to 42,000 taxi drivers, 84% of whom are immigrants (2). NYC taxi drivers work long hours (10-12 h/d shifts, ~6d/wk), often in heavy traffic (2). Exposure to high levels of respirable particulate matter (PM) Is closely linked to increased hospital admissions, lung cancer risk and mortality, and respiratory and cardiopulmonary mortality (3-9). Two studies have demonstrated high lung cancer prevalence among professional drivers, after adjusting for smoking, suggesting an association with PM exposure (10, 11). In a reanalysis of the Harvard Six Cities Study, each 10 upsilon g/m 3 increase in PM2.5 exposure was associated with an adjusted increased risk of all-cause mortality of 14% (95% Cl: 7, 22), and with a 37% (95% Cl: 7, 75) increase in lung cancer mortality (12). A 26- year prospective study found that each 10 upsilon g/m 3 increase in PM2.5 (PM <2.5 pm) exposure is associated with a 15-27% increase in lung cancer mortality among never-smokers (3). Taxi Particulate matter Study (TIPS) Is a community-engaged T1-T4 translational research study for at-risk taxi drivers in NYC. TIPS will address the following key research questions: 1) the extent to which excess PM exposure is associated with adverse changes in physiologic and biochemical markers, by comparing drivers with a driver-nominated non-taxi-driver peer comparison group; 2) the effect of an in-taxi HEPA filtration intervention on decreasing PM exposure and associated biomarker levels among taxi drivers randomized to the HEPA intervention in comparison with taxi drivers randomized to a control group. Participating taxi drivers will be randomized with a 1:1 ratio into either the control condition or the HEPA filter intervention condition. A third, driver-nominated matched peer reference group will serve as non-taxi-driver controls.

抽象的美国大约有24万美国出租车/豪华轿车司机（1）。纽约市（纽约市）是 42,000名出租车司机，其中84％是移民（2）。纽约出租车司机长时间工作（10-12 h/d轮班，〜6d/wk），通常在交通繁忙（2）。暴露于高水平的可呼吸颗粒物（PM）紧密联系增加住院，肺癌风险和死亡率以及呼吸和心肺死亡率（3-9）。两项研究表明，在调整后，专业驱动因素的肺癌患病率很高用于吸烟，建议与PM暴露相关（10，11）。在哈佛六个城市的重新分析中研究，每10个Upsilon g/m 3 PM2.5暴露量增加与调整后的全因风险增加有关死亡率为14％（95％CL：7，22），肺癌死亡率增加了37％（95％CL：7，75）（12）。 26-- 年度前瞻性研究发现，每10个Upsilon g/m 3 pm2.5（pm <2.5 pm）的暴露与从未吸烟者中，肺癌死亡率增加了15-27％（3）。出租车颗粒物研究（提示）是纽约市高危出租车司机的社区参与的T1-T4转化研究。提示将解决以下关键研究问题：1）与PM暴露过多相关的程度通过将驱动因素与驾驶员提名比较，生理和生化标记的不利变化非TAXI-DRIVER同伴比较组； 2）及时HEPA过滤的效果干预降低出租车司机中PM暴露和相关的生物标志物水平与随机分配给对照组的出租车司机相比，随机分配给HEPA干预措施。参与的出租车司机将以1：1的比率随机分配到控制条件或 HEPA滤波器干预条件。第三个驾驶员提名的匹配同伴参考组将服务作为非TAXI驱动器对照。