Developmental Core

发展核心

基本信息

批准号：
8327840
负责人：
KAREN HUBBARD
金额：
$ 143.54万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-02 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8327840
关键词：
Action Research Adult Advisory Committees Algorithms Area Arts Behavior Therapy Behavioral Sciences Belief Bioinformatics Biological Markers Biology Biomedical Engineering Biomedical Research Biometry Brain Cancer Center Caring Chronic Clinical Trials Cohort Studies Communication Communications Media Communities Community Health Education Community Outreach Computer Simulation Data Decision Making Development Education and Outreach Epidemiologist Epidemiology Faculty Gastroenterology Gene Expression Genetic Risk Goals Health Housing Human Impaired cognition Improve Access Incidence Individual Differences Institution Intervention Intervention Studies Lead Life Style Malignant Neoplasms Maps Medical Ethics Medicine Memorial Sloan-Kettering Cancer Center Methodology Minority Modeling Molecular Molecular Biology Molecular Genetics Morbidity - disease rate National Institute of Drug Abuse Neurocognitive Neurosciences Outcome Patients Pattern Pharmaceutical Preparations Pilot Projects Policies Population Population Genetics Primary Health Care Process Provider Psychiatry Psychologist Psychology Recommendation Recruitment Activity Research Research Personnel Risk Role Services Social Medicine Specialist Stress Stress and Coping System Target Populations Therapeutic To specify Work base biopsychosocial cancer risk chemotherapy cohort community intervention dissemination research falls genetic epidemiology health disparity health economics improved interest meetings member oncology psychosocial resilience response senescence simulation smoking cessation sociologist symposium

项目摘要

Developmental Core The following sections describe our major developmental activities over the next five years. 8.a. Faculty Recruitment Establishing Priorities for Faculty Recruitment: Early in our U54 Planning Process, we formed a Task Force to begin to map out topics that we would include in our Transdisciplinary Health Disparities Research Focus. The Task Force on Transdisciplinary Health Disparities Research that met in the summer and fall of 2006 included: Timothy Ahles, MSKCC Psychiatry Mary Alpaugh, CCNY Biology Carol Brown, MSKCC Gynecological Oncology Jack Burkhalter, MSKCC Behavioral Sciences Karen Hubbard, CCNY Biology Edward Keller, CCNY Media and Communication Arts Yuelin Li, MSKCC Psychiatry and Biostatistics David Lounsbury, MSKCC Behavioral Sciences Sara Olson, MSKCC Epidemiology Lucas Parra, CCNY Biomedical Engineering Bruce Rapkin, MSKCC Behavioral Sciences Manish Shah, MSKCC Gastroenterology Ann Marie Yali, CCNY Psychology Anne Zauber, MSKCC Epidemiology This Task Force generated themes described below. Each of these themes was identified as an area of priority by investigators at one or both institutions. In some instances, we do not have faculty partners identified who are working in a given area at both institutions. However, through regular symposia and on-going planning, we will develop recommendations for continuing development in each of these areas: Community-Based Intervention and Dissemination Research Rationale: We plan to recruit additional faculty with expertise in community intervention research. Investigators may be housed in MSKCC Departments of Psychiatry and Behavioral Science, Medicine, Epidemiology, or other area appropriate to their expertise. Additional faculty in community intervention is also a priority at CCNY in departments including Psychology, Adult Education, and Community Health & Social Medicine. Next Steps: We will seek scholars interested in working with diverse underserved communities, to improve standards of care, promote access, and encourage healthy lifestyles. Neurocognitive Impacts of Cancer Therapeutics Rationale: Drug induced senescence in the brain may lead to cognitive dysfunction. In their pilot project, Drs. Hubbard, Alhes and Ragnauth propose to identify gene expression patterns correlated with cognitive decline following chemotherapy. Faculty Recruitment Needs: Additional expertise in ^ molecular biology, neuroscience and gerontological oncology would help to advance this work. Participatory Research and the Identification of Biomarkers and Genetic Risks Rationale: As biomedical research seeks to identify more indicators of risk for cancer incidence or morbidity, it is necessary to maintain and follow cohorts representing distinct populations at different apparent risk. Participatory action research may be a promising way to engage and retain cohorts. Faculty Recruitment Needs: Specialists in molecular genetics, population genetics/epidemiology, bioinformatics/biostatisticians as well as and community-based participatory researchers. Increasing the Diversity of Patients on Cancer Clinical Trials Rationale: This goal is a central area of concern at MSKCC. CCNY scholars who study communications, decision-making, cultural beliefs, health economics and medical ethics could all contribute to this focus. In this application, Drs. Weiss and Binz-Sharf propose a pilot study examine primary care providers' role in improving access to trials. Faculty Recruitment Needs: CCNY is presently recruiting scholars in health economics and medical ethics that could contribute to this line of research. Biopsychosocial Research on Stress Rationale: Faculty expressed interest in examining the impact of chronic minority stress at the cellular level. Research would encompass biology of different cellular mechanisms as well as psychology of stress, coping and resilience. Many Task Force members saw ways to get involved in this area, including epidemiologist Olson and psychologists Burkhalter, Rosario and Yali. Faculty Recruitment Needs: The Task Force discussed the need for cohort studies in this area, involving molecular physiologists, epidemiologists, psychologists, and sociologists, and neuroendocrinologists. Next steps would be to specify target populations to consider, as well as ways to define minority stress. Mathematical Modeling and Simulation of Psychosocial and Behavioral Interventions Rationale: Psychosocial interventions often demonstrate substantial individual differences in responses. It may be possible to model intervention outcomes more accurately using algorithms to identify patterns in data. Co-Pi of the PCOP Lounsbury recently received an NIDA RO3 to conduct system dynamics modeling of smoking cessation in primary care. Systems dynamics is a simulation methodology valuable for assessing health and human services policies. Li and Rapkin at MSKCC are also highly interested in this area. Faculty Recruitment Needs: There may be potential to add faculty to the CCNY Center for Advanced Computing Algorithms.

发展核心以下各节描述了我们未来五年的主要发展活动。 8.a.师资招聘确定教师招聘的优先顺序：在 U54 规划流程的早期，我们成立了一个工作组来开始规划我们将要实施的主题纳入我们的跨学科健康差异研究重点。跨学科工作组 2006 年夏季和秋季举行的健康差异研究包括： Timothy Ahles，MSKCC 精神病学玛丽·阿尔波，CCNY 生物学卡罗尔·布朗 (Carol Brown)，MSKCC 妇科肿瘤学 Jack Burkhalter，MSKCC 行为科学凯伦·哈伯德，CCNY 生物学爱德华·凯勒 (Edward Keller)，CCNY 媒体和传播艺术李跃琳，MSKCC 精神病学和生物统计学 David Lounsbury，MSKCC 行为科学萨拉·奥尔森 (Sara Olson)，MSKCC 流行病学 Lucas Parra，CCNY 生物医学工程 Bruce Rapkin，MSKCC 行为科学 Manish Shah，MSKCC 胃肠病学 Ann Marie Yali，CCNY 心理学 Anne Zauber，MSKCC 流行病学该工作组生成了如下所述的主题。这些主题中的每一个都被确定为一个领域由一个或两个机构的调查人员优先考虑。在某些情况下，我们没有教师合作伙伴确定谁在两个机构的特定领域工作。然而，通过定期的研讨会和在持续规划中，我们将为这些领域的持续发展提出建议：基于社区的干预和传播研究理由：我们计划招募更多具有社区干预研究专业知识的教师。研究人员可能居住在 MSKCC 精神病学和行为科学系、医学系、流行病学或其他适合其专业知识的领域。社区干预方面的额外教师也是 CCNY 心理学、成人教育和社区健康等部门的优先考虑事项与社会医学。下一步：我们将寻找有兴趣与各种服务不足的群体合作的学者社区，以提高护理标准、促进获取并鼓励健康的生活方式。癌症治疗对神经认知的影响理由：药物引起的大脑衰老可能导致认知功能障碍。在他们的飞行员中项目，博士。 Hubbard、Alhes 和 Ragnauth 提议鉴定与以下因素相关的基因表达模式：化疗后认知能力下降。教师招聘需求：额外的专业知识^ 分子生物学、神经科学和老年肿瘤学将有助于推进这项工作。参与性研究以及生物标志物和遗传风险的识别理由：随着生物医学研究寻求确定更多癌症发病风险指标或发病率，有必要维持和跟踪代表不同人群的队列明显的风险。参与性行动研究可能是吸引和留住群体的一种有前途的方式。教师招聘需求：分子遗传学、群体遗传学/流行病学、生物信息学/生物统计学家以及基于社区的参与性研究人员。增加癌症临床试验患者的多样性理由：该目标是 MSKCC 关注的中心领域。研究传播学的 CCNY 学者，决策、文化信仰、卫生经济学和医学伦理学都可以促进这一重点。在这个应用程序中，博士。 Weiss 和 Binz-Sharf 提出一项试点研究，检查初级保健提供者的作用改善获得审判的机会。教师招聘需求：CCNY目前正在招聘以下领域的学者：健康经济学和医学伦理学可能有助于这一领域的研究。关于压力的生物心理社会研究理由：教师们表示有兴趣研究慢性少数民族压力对细胞的影响等级。研究将涵盖不同细胞机制的生物学以及心理学压力、应对和恢复力。许多工作组成员找到了参与这一领域的方法，包括流行病学家奥尔森和心理学家伯克哈特、罗萨里奥和亚利。教师招聘需求：工作组讨论了该领域开展队列研究的必要性，其中包括分子生理学家、流行病学家、心理学家、社会学家和神经内分泌学家。下一步是指定要考虑的目标人群，以及定义少数群体压力的方法。心理社会和行为干预的数学建模和模拟理由：心理社会干预通常表现出巨大的个体反应差异。使用算法识别模式可以更准确地对干预结果进行建模在数据中。 PCOP Lounsbury 的 Co-Pi 最近收到了 NIDA RO3 来进行系统动力学初级保健中的戒烟建模。系统动力学是一种有价值的模拟方法用于评估健康和人类服务政策。 MSKCC 的 Li 和 Rapkin 也非常感兴趣这个区域。教师招聘需求：CCNY 中心有可能增加教师先进的计算算法。