Airway Inspector: a chest imaging biomarker software platform for COPD

Airway Inspector：用于 COPD 的胸部成像生物标志物软件平台

• 批准号: 8605217
• 负责人: Raul San Jose Estepar
• 金额: $ 43.27万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-14 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8605217
• 关键词: Adopted; Affect; Algorithms; Biological Markers; Blood Vessels; Caring; Cause of Death; Chest; Chronic Bronchitis; Chronic Obstructive Airway Disease; Classification; Classification Scheme; Clinical; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Communities; Comorbidity; Computer software; Country; Data; Development; Diagnosis; Disease; Documentation; Forced expiratory volume function; Fostering; Genetic Research; Goals; Heterogeneity; Housing; Image; Image Analysis; Individual; International; Label; Laboratories; Lead; Libraries; Life; Lung; Lung diseases; Measures; Methods; Metric; Monitor; Obstruction; Participant; Peer Review; Phenotype; Physiological; Pilot Projects; Process; Public Health; Publications; Pulmonary Emphysema; Pulmonary Function Test/Forced Expiratory Volume 1; Relative (related person); Research; Research Personnel; Resolution; Respiratory physiology; Scanning; Severities; Slice; Software Tools; Solutions; Source Code; Spirometry; Structure; Structure of parenchyma of lung; Subgroup; Surrogate Endpoint; Syndrome; Technology; Testing; Time; Tissues; United States; United States National Institutes of Health; Update; Validation; Vascular Diseases; Vascular remodeling; Woman; X-Ray Computed Tomography; base; burden of illness; clinical phenotype; cohort; commercial application; density; design; functional disability; genetic association; hospital analysis; image processing; interest; lung basal segment; lung imaging; markov model; mortality; novel; open source; particle; population based; public health relevance; small airways disease; software development; success; tool; virtual

DESCRIPTION (provided by applicant): Chronic Obstructive Pulmonary Disease affects up to 24 million people in the United States and is projected to be the 3rd leading cause of death worldwide by 2020. COPD has been traditionally dichotomized into the clinical phenotypes of emphysema and chronic bronchitis. Although spirometry is critical for diagnosis of COPD, FEV1 may be of limited value in a classification scheme designed to illuminate differences in disease mechanism among individuals." Computed tomographic (CT) imaging of the lung is a tool that may fulfill the need of new biomarkers to: facilitate the creation and testing of novel therapies, act as surrogate endpoints for clinical trials and provide researchers with the ability to reduce the heterogeneity of a cohort of subjects with COPD into more homogeneous subgroups to assist in monitoring study endpoints Airway Inspector is a open source software tool based on Slicer 2.x developed at Brigham and Women's Hospital for the analysis of chest CT scans for the analysis of emphysema and airway disease. The tool was conceived to analysis low resolution CT scans bringing the gap between retrospective data and new emerging CT technologies. The success of the tool in the COPD clinical community is supported by the array of peer- review publications that have used the tool to define metrics of disease that enable hypothesis driven research. Beside the existence of alternative commercial applications, Airway Inspector is the only freely available maintained platform for COPD research. In spite of its success, Airway Inspector is limited to a discontinued version of Slicer. The broad objective of this proposal is to support the refactoring and development of Airway Inspector as a platform for image-based COPD research. This goal will be achieved by the creation of the Chest Imaging Biomarker Platform (CIBP) library that integrates novel algorithm solutions to lung image analysis that have been developed in our laboratory. Those solutions include: robust lung extraction, parenchymal tissue classification based on local density, airway, fissure and pulmonary vascular extraction based on scale-space particles and airway labeling based on Hidden Markov Models. That software platform will be used to create workflows that will be integrated in Slicer 4 for their deployment in the clinical community. Slicer 4 is a NIH supported open software general purpose imaging software platform that is specifically designed to integrate solutions like Airway Inspector. The workflows will provide an end-to-end solution for the clinical to obtain phenotypes to characterize emphysema, airway disease and pulmonary vascular remodeling.

描述（由申请人提供）：慢性阻塞性肺病影响美国多达 2400 万人，预计到 2020 年将成为全球第三大死因。慢性阻塞性肺病传统上分为肺气肿和慢性支气管炎的临床表型。虽然肺活量测定对于 COPD 的诊断至关重要，但 FEV1 在旨在阐明个体间疾病机制差异的分类方案中可能价值有限。” 肺部计算机断层扫描 (CT) 成像是一种可以满足新生物标志物需求的工具目的：促进新疗法的创建和测试，作为临床试验的替代终点，并为研究人员提供将 COPD 受试者队列的异质性减少到更同质亚组的能力，以协助监测研究终点Inspector 是布莱根妇女医院开发的基于 Slicer 2.x 的开源软件工具，用于分析胸部 CT 扫描以分析肺气肿和气道疾病。该工具旨在分析低分辨率 CT 扫描，从而消除回顾性扫描之间的差距。该工具在 COPD 临床界的成功得到了一系列同行评审出版物的支持，这些出版物使用该工具来定义疾病指标，从而实现假设驱动的研究。除了存在替代商业应用程序之外，Airway Inspector 是唯一免费提供的 COPD 研究维护平台。尽管取得了成功，Airway Inspector 仍仅限于 Slicer 的停产版本。该提案的总体目标是支持 Airway Inspector 的重构和开发，作为基于图像的 COPD 研究平台。这一目标将通过创建胸部成像生物标记平台（CIBP）库来实现，该库将我们实验室开发的肺部图像分析新颖算法解决方案集成起来。这些解决方案包括：稳健的肺提取、基于局部密度的实质组织分类、基于尺度空间粒子的气道、裂隙和肺血管提取以及基于隐马尔可夫模型的气道标记。该软件平台将用于创建工作流程，并将其集成到 Slicer 4 中，以便在临床社区中部署。 Slicer 4 是 NIH 支持的开放式软件通用成像软件平台，专门设计用于集成 Airway Inspector 等解决方案。该工作流程将为临床提供端到端解决方案，以获得表征肺气肿、气道疾病和肺血管重塑的表型。