Airway Inspector: a chest imaging biomarker software platform for COPD

Airway Inspector：用于 COPD 的胸部成像生物标志物软件平台

• 批准号: 8421710
• 负责人: Raul San Jose Estepar
• 金额: $ 44.03万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-14 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8421710
• 关键词: Adopted; Affect; Algorithms; Biological Markers; Blood Vessels; Caring; Cause of Death; Chest; Chronic Bronchitis; Chronic Obstructive Airway Disease; Classification; Classification Scheme; Clinical; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Communities; Comorbidity; Computer software; Country; Data; Development; Diagnosis; Disease; Documentation; Forced expiratory volume function; Fostering; Genetic Research; Goals; Heterogeneity; Housing; Image; Image Analysis; Individual; International; Label; Laboratories; Lead; Libraries; Life; Lung; Lung diseases; Measures; Methods; Metric; Monitor; Obstruction; Participant; Peer Review; Phenotype; Physiological; Pilot Projects; Process; Public Health; Publications; Pulmonary Emphysema; Pulmonary Function Test/Forced Expiratory Volume 1; Relative (related person); Research; Research Personnel; Resolution; Respiratory physiology; Scanning; Severities; Slice; Software Tools; Solutions; Source Code; Spirometry; Structure; Structure of parenchyma of lung; Subgroup; Surrogate Endpoint; Syndrome; Technology; Testing; Time; Tissues; United States; United States National Institutes of Health; Update; Validation; Vascular Diseases; Vascular remodeling; Woman; X-Ray Computed Tomography; base; burden of illness; clinical phenotype; cohort; commercial application; density; design; functional disability; genetic association; hospital analysis; image processing; interest; lung basal segment; lung imaging; markov model; mortality; novel; open source; particle; population based; public health relevance; small airways disease; software development; success; tool; virtual

DESCRIPTION (provided by applicant): Chronic Obstructive Pulmonary Disease affects up to 24 million people in the United States and is projected to be the 3rd leading cause of death worldwide by 2020. COPD has been traditionally dichotomized into the clinical phenotypes of emphysema and chronic bronchitis. Although spirometry is critical for diagnosis of COPD, FEV1 may be of limited value in a classification scheme designed to illuminate differences in disease mechanism among individuals." Computed tomographic (CT) imaging of the lung is a tool that may fulfill the need of new biomarkers to: facilitate the creation and testing of novel therapies, act as surrogate endpoints for clinical trials and provide researchers with the ability to reduce the heterogeneity of a cohort of subjects with COPD into more homogeneous subgroups to assist in monitoring study endpoints Airway Inspector is a open source software tool based on Slicer 2.x developed at Brigham and Women's Hospital for the analysis of chest CT scans for the analysis of emphysema and airway disease. The tool was conceived to analysis low resolution CT scans bringing the gap between retrospective data and new emerging CT technologies. The success of the tool in the COPD clinical community is supported by the array of peer- review publications that have used the tool to define metrics of disease that enable hypothesis driven research. Beside the existence of alternative commercial applications, Airway Inspector is the only freely available maintained platform for COPD research. In spite of its success, Airway Inspector is limited to a discontinued version of Slicer. The broad objective of this proposal is to support the refactoring and development of Airway Inspector as a platform for image-based COPD research. This goal will be achieved by the creation of the Chest Imaging Biomarker Platform (CIBP) library that integrates novel algorithm solutions to lung image analysis that have been developed in our laboratory. Those solutions include: robust lung extraction, parenchymal tissue classification based on local density, airway, fissure and pulmonary vascular extraction based on scale-space particles and airway labeling based on Hidden Markov Models. That software platform will be used to create workflows that will be integrated in Slicer 4 for their deployment in the clinical community. Slicer 4 is a NIH supported open software general purpose imaging software platform that is specifically designed to integrate solutions like Airway Inspector. The workflows will provide an end-to-end solution for the clinical to obtain phenotypes to characterize emphysema, airway disease and pulmonary vascular remodeling.

描述（由申请人提供）：慢性阻塞性肺部疾病在美国影响多达2400万人，并预计到2020年将成为全球第三大死亡原因。传统上，COPD被二分化为肺气肿和慢性支气管炎的临床表型。尽管肺活量测量对于诊断COPD至关重要，但FEV1在旨在阐明个体疾病机制差异的分类方案中可能具有有限的价值。将COPD的受试者纳入更均匀的亚组，以帮助监测终点，这是基于在Brigham和妇女医院开发的开源软件工具，用于分析胸部CT扫描，以分析肺气道和气道疾病的分析，以分析较高的分辨率CT扫描。在COPD中，临床界得到了一系列同行评审出版物的支持，这些出版物已使用该工具来定义疾病的指标，从而实现了假设驱动的研究。除了存在替代商业应用外，气道检查员是唯一可免费获得的COPD研究平台。尽管它取得了成功，但Airway Inspector仅限于已停产的Slicer版本。该提案的广泛目标是支持Airway Inspector作为基于图像的COPD研究的平台的重构和开发。这一目标将通过创建胸部成像生物标志物平台（CIBP）库来实现，该平台将新颖的算法解决方案集成到我们实验室中已经开发的肺图像分析中。这些解决方案包括：基于局部密度，气道，裂缝和肺血管提取基于尺度空间颗粒和基于隐藏的马尔可夫模型的气道标记，良好的肺萃取，实质组织分类。该软件平台将用于创建将在Slicer 4中集成的工作流程，以在临床社区的部署。 Slicer 4是NIH支持的开放软件通用成像软件平台，专门设计用于整合诸如Airway Inspector之类的解决方案。工作流将为临床提供端到端解决方案，以获得表征表征肺气肿，气道疾病和肺血管重塑的表型。