Air pollution effects on asthma and lung function in Hispanic children

空气污染对西班牙裔儿童哮喘和肺功能的影响

• 批准号: 8686858
• 负责人: William JAMES GAUDERMAN
• 金额: $ 8.14万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-20 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8686858
• 关键词: Accounting; Address; Adolescent; Affect; Air Pollutants; Air Pollution; Area; Asthma; Carbon; Caucasians; Caucasoid Race; Child; Child health care; Childhood; Childhood Asthma; Communities; Data; Development; Epidemiologic Studies; Ethnic group; Exposure to; Genes; Genetic; Genotype; Geographic Locations; Growth; Hand; Health; Heterogeneity; Hispanic Americans; Hispanics; Individual; Life; Metals; Minority; Native Americans; Not Hispanic or Latino; Outcome; Pollution; Population; Population Heterogeneity; Respiratory physiology; Risk; Risk Estimate; Sampling; Socioeconomic Status; Statistical Models; Subgroup; Tobacco smoke; United States; Variant; base; caucasian American; cofactor; directed attention; pollutant; public health relevance; respiratory; trafficking

DESCRIPTION (provided by applicant): Hispanic-Americans have received little direct attention in air-pollution studies conducted to date, despite the fact that they are a growing minority and now represent the majority population in many areas of the United States. Self-identified Hispanics are a heterogeneous population with ancestries (and corresponding exposure and health distributions) that vary substantially across individuals. In this project, we will address the following four hypotheses: " Hypothesis 1: Hispanic white (HW) children are more highly exposed to air pollution than non-Hispanic white (NHW) children. " Hypothesis 2: The effect of air pollution on childhood asthma and lung function development is greater in HW children than in NHW children. "Hypothesis 3: Underlying ancestry within Hispanics is associated with differences in childhood exposure to air pollution." Hypothesis 4: Accurate assessment of air pollution risks in a Hispanic population requires accounting for the possible confounding and modifying effects of underlying ancestry. To address these hypotheses, we will capitalize on existing data in the Children's Health Study (CHS), including longitudinal respiratory health data on over 12,000 children, with 40% (4,800) of Hispanic descent. We will utilize extensive air pollution data recorded over 16 years to study exposures and health effects of several criteria pollutants, including PM10, PM2.5, NO2, and O3, and additional pollutants related to traffic exposure (e.g. NO, elemental carbon, metals). We will also utilize existing genotype data to accurately characterize the ancestral heterogeneity within our Hispanic population. We will examine how that heterogeneity relates to pollution exposure and in turn how it affects population-level estimates of risk. We will use sophisticated statistical models and will carefully consider a wide range of additional cofactors (e.g. socio- economic status, second-hand tobacco smoke) in our analyses. Successful completion of this project will significantly advance our understanding of air pollution exposures and corresponding health effects in Hispanics, a large and growing population in the United States.

描述（由申请人提供）： 迄今为止，西班牙裔美国人在空气污染研究中几乎没有受到直接关注，尽管他们是一个不断增长的少数群体，并且现在代表了美国许多地区的大多数人口。自我认同的西班牙裔人是一个异质群体，其血统（以及相应的暴露和健康分布）在个体之间存在很大差异。在这个项目中，我们将提出以下四个假设：“假设1： 西班牙裔白人 (HW) 儿童比非西班牙裔白人 (NHW) 儿童更容易受到空气污染的影响。假设 2：空气污染对健康家庭儿童的儿童哮喘和肺功能发育的影响大于非健康家庭儿童。假设 3：西班牙裔的潜在血统与童年接触空气污染的差异有关。假设 4：准确评估西班牙裔人口的空气污染风险需要考虑潜在血统可能产生的混杂和改变影响。为了解决这些假设，我们将利用现有数据。儿童健康研究 (CHS)，包括超过 12,000 名儿童的纵向呼吸健康数据，其中 40% (4,800) 是西班牙裔。我们将利用 16 年来记录的大量空气污染数据来研究多种标准污染物的暴露和健康影响，包括 PM10、PM2.5、NO2 和 O3，以及与交通暴露相关的其他污染物（例如 NO、元素碳、金属）。我们还将利用现有的基因型。数据来准确描述我们西班牙裔人口中的祖先异质性。我们将研究这种异质性与污染暴露的关系，以及它如何影响人口层面的风险估计。我们将使用复杂的统计模型，并在分析中仔细考虑各种其他辅助因素（例如社会经济地位、二手烟草烟雾）。该项目的成功完成将极大地增进我们对西班牙裔美国人（美国人口众多且不断增长的人口）的空气污染暴露及其相应健康影响的了解。