Accelerating Autoimmune Treatments through Alopecia Areata Research

通过斑秃研究加速自身免疫治疗

• 批准号: 8969037
• 负责人: DAVID A. NORRIS
• 金额: $ 1万
• 依托单位: NATIONAL ALOPECIA AREATA FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8969037
• 关键词: Address; Affect; Age; Alopecia Areata; American; Animal Model; Autoimmune Diseases; Autoimmune Process; Biological Products; Clinical Research; Clinical Trials; Collaborations; Comorbidity; Dermatology; Development; Disabled Persons; Discipline; Disease; Ensure; Equilibrium; Ethnic Origin; Family member; Fostering; Foundations; Funding; Future; Genetic; Genomics; Goals; Government Agencies; Grant; Hair; Health; Hearing; Heredity; Immune Targeting; Immunology; Insulin-Dependent Diabetes Mellitus; Knowledge; Lead; Learning; Life; Methods; Minority; Mission; Monitor; Nonprofit Organizations; Participant; Patients; Phototherapy; Process; Public Health; Published Comment; Publishing; Race; Registries; Research; Research Design; Research Personnel; Research Priority; Research Project Grants; Research Proposals; Research Support; Risk; Seasons; Series; Talents; Testing; Time; United States National Institutes of Health; Voice; Woman; base; career; clinical investigation; disease natural history; improved; innovation; medical specialties; meetings; posters; psychologic; social

DESCRIPTION (provided by applicant): Alopecia areata is a disease characterized by hair loss that affects 6.5 million Americans of all ages, races and ethnicities. It occurs more frequently in people who have affected family members, suggesting heredity and genetics are a factor in disease occurrence. The profound effects of the disease are physical, social and psychological. The National Alopecia Areata Foundation (NAAF) is a nonprofit organization that supports research to find a cure or acceptable treatment for alopecia areata, supports those with the disease, and educates the public about alopecia areata. This summit is central to the research mission of the Foundation: bringing together investigators from relevant specialties around the world to distill learning from previous research advances and determine future priorities. NAAF uses these priorities to evaluate research proposals and make grant funding decisions. The long-term objective is a safe, effective, affordable treatment or a cure for alopecia areata. This research summit is planned for December 4-5, 2014 in Bethesda, MD. The summit will bring together esteemed researchers representing genetics, immunology, related autoimmune diseases like type 1 diabetes, dermatology and other fields including phototherapy. Summit objectives are to: 1) review new knowledge; 2) identify and prioritize promising new needed research; 3) develop plans and facilitate partnerships; and 4) publish meeting results to share findings. Inclusion of women, minorities, and people with disabilities is a priority so we draw on a broad and balanced field of knowledge. We encourage early-career investigators to join us and bring fresh ideas and new talent. Attendees with alopecia areata will ensure that the patient perspective is heard and considered in the prioritization process. The design of this research summit is two days combining a series of short presentations with expansive discussion facilitated by each participant having a microphone. Key findings are periodically summarized by senior researchers and co-chairs will lead presenters and participants to collectively analyze findings and recommend new research priorities and partnerships. Our method of enabling researchers to hear findings across multiple disciplines and engage in substantive Q&A and discussion fosters innovation and collaboration.

描述（由申请人提供）：Areata脱发是一种疾病，其特征是脱发，影响650万年龄，种族和种族的美国人。 它在影响家庭成员的人中更频繁地发生，这表明遗传和遗传学是疾病发生的一个因素。 疾病的深刻影响是身体，社会和心理的。 国家脱发Areata基金会（NAAF）是一个非营利组织，支持研究以寻找治疗或可接受的脱发治疗方法，支持患有该疾病的人，并向公众教育有关脱发的Areata。 这次峰会是该基金会研究任务的核心：将来自世界各地相关专业的调查人员聚集在一起，以从先前的研究进展中提取学习并确定未来的优先事项。 NAAF使用这些优先事项来评估研究建议并做出赠款决定。 长期目标是一种安全，有效，负担得起的治疗或脱发脱发的方法。该研究峰会计划于2014年12月4日至5日在马里兰州贝塞斯达举行。 峰会将汇集代表遗传学，免疫学，相关自身免疫性疾病（如1型糖尿病，皮肤病学和其他领域）（包括光疗）的尊敬的研究人员。 峰会目标是：1）审查新知识； 2）确定并确定有希望的新需要的研究； 3）制定计划并促进伙伴关系； 4）发布会议结果以分享调查结果。 包括妇女，少数民族和残疾人是 优先事项，因此我们借鉴了广泛而平衡的知识领域。 我们鼓励早期研究人员加入我们，并带来新的想法和新的人才。 与脱发Areata的与会者将 确保在优先级的过程中聆听和考虑患者的观点。这次研究峰会的设计是两天，结合了一系列简短的演示文稿以及每个具有麦克风的参与者促进的广泛讨论。 高级研究人员定期概括了关键发现，联合主席将导致演示者和参与者共同分析发现并推荐新的研究重点和伙伴关系。 我们的方法使研究人员能够聆听跨多个学科的发现，并进行实质性的问答和讨论促进了创新和协作。

项目成果

Eosinophilic Esophagitis: Another Atopy-Related Alopecia Areata Trigger?

嗜酸性粒细胞性食管炎：另一种与特应性相关的斑秃触发因素？

• DOI: 10.1038/jidsymp.2015.43
• 发表时间: 2015
• 期刊: The journal of investigative dermatology. Symposium proceedings
• 作者: Ibrahim,Omer;Bergfeld,WilmaF;Piliang,Melissa
• 通讯作者: Piliang,Melissa

Current Treatments for Alopecia Areata.

• DOI: 10.1038/jidsymp.2015.41
• 发表时间: 2015-11-01
• 期刊: The journal of investigative dermatology. Symposium proceedings
• 作者: Hordinsky, Maria K

Overview of AA and Research Progress: What Have We Learned and Where Are We Headed?

AA 概述和研究进展：我们学到了什么以及我们将走向何方？

• DOI: 10.1038/jidsymp.2015.30
• 发表时间: 2015
• 期刊: The journal of investigative dermatology. Symposium proceedings
• 作者: Norris,DavidA

From Targets to Treatments: Bridging Autoimmune Research to Advance Understanding of Alopecia Areata.

从目标到治疗：通过自身免疫研究促进对斑秃的了解。

• DOI: 10.1038/jidsymp.2015.29
• 发表时间: 2015
• 期刊: The journal of investigative dermatology. Symposium proceedings
• 作者: Kranz,Dory;Ellison,Abby;Frelinger,JeffreyA;Mackay-Wiggan,Julian;Norris,DavidA
• 通讯作者: Norris,DavidA

Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients.

• DOI: 10.1038/jidsymp.2015.28
• 发表时间: 2015-11-01
• 期刊: The journal of investigative dermatology. Symposium proceedings
• 作者: Chiang, Katherine S;Mesinkovska, Natasha A;Bergfeld, Wilma F
• 通讯作者: Bergfeld, Wilma F