Molecular Analysis, Modeling and Correction of Skin Diseases

皮肤病的分子分析、建模和纠正

基本信息

批准号：
8519055
负责人：
DAVID A. NORRIS
金额：
$ 59.68万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2014-08-19
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8519055
关键词：
Address Animal Model Applications Grants Area Autoimmune Process Award Basic Science Biochemistry Biology Chairperson Clinical Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Collaborations Colorado Core Facility Cutaneous Dermatology Development Developmental Biology Discipline of Nursing Disease Educational process of instructing Environment Epithelial Flow Cytometry Foundations Funding Future Gene Targeting Genetic Genetic Programming Genetic Skin Diseases Genetically Engineered Mouse Genomics Goals Growth Head Housing Human Immune Immunity Inflammation Inflammatory Institution Interdisciplinary Study Investments Medical Medical Genetics Metabolic Microbiology Modeling Molecular Molecular Analysis Molecular Genetics Molecular and Cellular Biology Morphology Movement National Institute of Arthritis and Musculoskeletal and Skin Diseases Natural Immunity Pharmacology Pharmacy facility Phenotype Program Development Public Health Dentistry Reagent Regenerative Medicine Research Research Personnel Research Project Grants Research Training Role Schools Scientist Site Skin Stem cells Structure Transgenic Organisms Translational Research Universities adaptive immunity appendage base clinical care genetic analysis insight interest keratinocyte medical schools melanocyte mouse model novel strategies novel therapeutic intervention programs response skin disorder stem cell biology tissue repair virology

项目摘要

DESCRIPTION (provided by applicant): This is a new proposal to establish the University of Colorado-Denver Skin Diseases Research Core Center (UCD-SDRC). This center will emphasize understanding the molecular basis of human autoimmune, inflammatory, developmental, metabolic and genetic skin diseases and development of genetically engineered mouse models which mimic these disorders at both the genetic and phenoty pic levels. These mouse models will be utilized for the development of new therapeutic approaches, such as stem cell-based treatments. This Center includes 49 investigators, 15 from within the Department of Dermatology and 34 from other UCD Departments or from other sites collaborating with UCD. The research interests of these investigators are broad: Inflammation and immunity, epithelial biology, melanocyte biology, regenerative medicine and stem cell biology, molecular cellular and developmental biology, biochemistry, pharmacology, microbiology and virology, genetics and genomics, tissue repair, cutaneous carcinogensis, and clinical research. This is a rich platform for interdisciplinary discovery in basic and translational research. This proposal has four Specific Aims: 1. To provide Core facilities as a platform for interdisciplinary discovery in basic and translational research, an Administrative Core, Molecular Genetic Analysis Core, Transgenic and Gene Targeting Core, Morphology and Phenotyping Core, and a Flow Cytometry Core: 2 To organize a robust Pilot and Feasibility program to attract new investigators (young, as well as, established) into research in the skin and skin disease. Six new P&F projects are included in this application, as well as a structure for selection of future projects; 3 To organize an Enrichment Program for the UCD-SDRC; 4 To assemble a Clinical Investigations Team to facilitate development of translational research projects based on the basic research discoveries supported by the cores and P&F studies. The long-term goal of the UCD-SDRC is to provide opportunities for novel approaches and insights into cutaneous biology, pathobiology and clinical dermatology through coordinating and nurturing multidisciplinary research, training, and clinical care among a variety of highly successful basic science and clinical investigators.

描述（由申请人提供）：这是建立科罗拉多大学丹佛皮肤病研究核心中心（UCD-SDRC）的新提案。该中心将重点了解人类自身免疫性、炎症性、发育性、代谢性和遗传性皮肤病的分子基础，并开发在遗传和表型水平上模拟这些疾病的基因工程小鼠模型。这些小鼠模型将用于开发新的治疗方法，例如基于干细胞的治疗。该中心包括 49 名研究人员，其中 15 名来自皮肤科，34 名来自都柏林大学其他科室或与都柏林大学合作的其他机构。这些研究人员的研究兴趣广泛：炎症和免疫、上皮生物学、黑素细胞生物学、再生医学和干细胞生物学、分子细胞和发育生物学、生物化学、药理学、微生物学和病毒学、遗传学和基因组学、组织修复、皮肤致癌、和临床研究。这是基础和转化研究跨学科发现的丰富平台。该提案有四个具体目标： 1. 提供核心设施作为基础和转化研究跨学科发现的平台，包括行政核心、分子遗传分析核心、转基因和基因靶向核心、形态学和表型分析核心以及流式细胞术核心：2 组织一个强有力的试点和可行性计划，以吸引新的研究人员（年轻的和成熟的）参与皮肤和皮肤疾病的研究。此应用程序中包含六个新的 P&F 项目，以及用于选择未来项目的结构； 3 为 UCD-SDRC 组织丰富计划； 4 组建临床研究团队，以促进基于核心和 P&F 研究支持的基础研究发现的转化研究项目的开发。 UCD-SDRC 的长期目标是通过协调和培养各种非常成功的基础科学和临床研究人员的多学科研究、培训和临床护理，为皮肤生物学、病理学和临床皮肤病学的新方法和见解提供机会。