Molecular Analysis, Modeling and Correction of Skin Diseases

皮肤病的分子分析、建模和纠正

• 批准号: 8519055
• 负责人: DAVID A. NORRIS
• 金额: $ 59.68万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-08-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8519055
• 关键词: Address; Animal Model; Applications Grants; Area; Autoimmune Process; Award; Basic Science; Biochemistry; Biology; Chairperson; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorado; Core Facility; Cutaneous; Dermatology; Development; Developmental Biology; Discipline of Nursing; Disease; Educational process of instructing; Environment; Epithelial; Flow Cytometry; Foundations; Funding; Future; Gene Targeting; Genetic; Genetic Programming; Genetic Skin Diseases; Genetically Engineered Mouse; Genomics; Goals; Growth; Head; Housing; Human; Immune; Immunity; Inflammation; Inflammatory; Institution; Interdisciplinary Study; Investments; Medical; Medical Genetics; Metabolic; Microbiology; Modeling; Molecular; Molecular Analysis; Molecular Genetics; Molecular and Cellular Biology; Morphology; Movement; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Immunity; Pharmacology; Pharmacy facility; Phenotype; Program Development; Public Health Dentistry; Reagent; Regenerative Medicine; Research; Research Personnel; Research Project Grants; Research Training; Role; Schools; Scientist; Site; Skin; Stem cells; Structure; Transgenic Organisms; Translational Research; Universities; adaptive immunity; appendage; base; clinical care; genetic analysis; insight; interest; keratinocyte; medical schools; melanocyte; mouse model; novel strategies; novel therapeutic intervention; programs; response; skin disorder; stem cell biology; tissue repair; virology

DESCRIPTION (provided by applicant): This is a new proposal to establish the University of Colorado-Denver Skin Diseases Research Core Center (UCD-SDRC). This center will emphasize understanding the molecular basis of human autoimmune, inflammatory, developmental, metabolic and genetic skin diseases and development of genetically engineered mouse models which mimic these disorders at both the genetic and phenoty pic levels. These mouse models will be utilized for the development of new therapeutic approaches, such as stem cell-based treatments. This Center includes 49 investigators, 15 from within the Department of Dermatology and 34 from other UCD Departments or from other sites collaborating with UCD. The research interests of these investigators are broad: Inflammation and immunity, epithelial biology, melanocyte biology, regenerative medicine and stem cell biology, molecular cellular and developmental biology, biochemistry, pharmacology, microbiology and virology, genetics and genomics, tissue repair, cutaneous carcinogensis, and clinical research. This is a rich platform for interdisciplinary discovery in basic and translational research. This proposal has four Specific Aims: 1. To provide Core facilities as a platform for interdisciplinary discovery in basic and translational research, an Administrative Core, Molecular Genetic Analysis Core, Transgenic and Gene Targeting Core, Morphology and Phenotyping Core, and a Flow Cytometry Core: 2 To organize a robust Pilot and Feasibility program to attract new investigators (young, as well as, established) into research in the skin and skin disease. Six new P&F projects are included in this application, as well as a structure for selection of future projects; 3 To organize an Enrichment Program for the UCD-SDRC; 4 To assemble a Clinical Investigations Team to facilitate development of translational research projects based on the basic research discoveries supported by the cores and P&F studies. The long-term goal of the UCD-SDRC is to provide opportunities for novel approaches and insights into cutaneous biology, pathobiology and clinical dermatology through coordinating and nurturing multidisciplinary research, training, and clinical care among a variety of highly successful basic science and clinical investigators.

描述（由申请人提供）：这是建立科罗拉多大学皮肤疾病研究核心中心（UCD-SDRC）的新建议。该中心将强调了解人自身免疫性，炎症，发育，代谢和遗传性皮肤疾病的分子基础，以及基因工程小鼠模型的发展，这些模型在遗传和表PIC水平上模仿这些疾病。这些小鼠模型将用于开发新的治疗方法，例如基于干细胞的治疗方法。该中心包括49位调查人员，15个来自皮肤病学系的调查人员，其他UCD部门或与UCD合作的其他站点的34个。这些研究者的研究兴趣是广泛的：炎症和免疫力，上皮生物学，黑色素细胞生物学，再生医学和干细胞生物学，分子细胞和发育生物学，生物化学，药理学，微生物学和病毒学和病毒学，遗传学和基因组学，组织修复，皮肤造影，以及临床研究。这是基础研究和转化研究中跨学科发现的丰富平台。该提案具有四个具体目的：1。提供核心设施作为基础和转化研究中的跨学科发现的平台，一种行政核心，分子遗传分析核心，转基因和基因靶向核心，形态和表型核心，以及流式细胞术以及一个核心：2核心：2，以对既有疾病的疾病进行了研究，以吸引了新的调查人员（又是新调查人员），并促进了新调查的疾病（以及新的调查者）。本申请中包括六个新的P＆F项目，以及用于选择未来项目的结构； 3为UCD-SDRC组织一个富集计划； 4组建一个临床调查团队，以促进基于核心和P＆F研究支持的基础研究发现的转化研究项目。 UCD-SDRC的长期目标是通过协调和培养各种非常成功的基础科学和临床研究人员之间的多学科研究，培训和临床护理，为皮肤生物学，病理生物学和临床皮肤病学提供新的方法和见解。