Molecular Genetic Analysis Core

分子遗传分析核心

• 批准号: 7677653
• 负责人: DAVID A. NORRIS
• 金额: $ 14.68万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7677653
• 关键词: Biological; Core Facility; DNA Markers; DNA Sequence; DNA Sequence Analysis; Development; Equipment; Funding; Gene Expression; Genes; Genetic; Genetic Markers; Genetic Transcription; Genotype; Human; Human Resources; Individual; Investigation; Laboratory Research; Maps; Modeling; Molecular Analysis; Molecular Genetics; Mus; Patients; Price; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Services; Single Nucleotide Polymorphism; Skin; Technology; Training; cost; design; discount; genetic analysis; genetic technology; genome-wide; high standard; member; skin disorder; tool

A fundamental need of investigators studying skin disease is to carry out a number of different molecular genetic technologies, including the ability to map, identify, and characterize genes involve in skin differentiation, skin development, skin damage, and skin disease. These analyses require access to specialized high-cost equipment and highly trained personnel with specialized expertise, beyond what is typically available in most individual research laboratories. The objective of the UCD-SDRC Molecular Genetic Analysis Core is to provide investigators with the necessary tools and expertise for both large-scale and smaller-scale, user-defined genotyping of polymorphic genetic markers, large-scale and small-scale DNA sequencing, and for genomewide, multi-gene, and single-gene RNA expression analyses. Each of these technologies requires high-cost items of equipment and expertise, and the UCD-SDRC Molecular Genetic Analysis Core will coordinate access among several existing oncampus core facilities that own and operate the equipment necessary for all of these technologies, to provide these services to UCD-SDCR members at discount pricing compared to either the unsubsidized cost of these services from these core labs or the cost of these services from commercial entities. In addition, the UCD-SDRC Molecular Genetic Analysis Core will provide expertise to investigators in design of genetic studies, so as to optimize use of valuable patient samples and resources to allow investigators to answer important research questions in skin disease.

研究皮肤病的研究者的一个基本需求是进行许多不同的分子遗传学研究 技术，包括绘制、识别和表征参与皮肤分化、皮肤 发育、皮肤损伤和皮肤病。这些分析需要使用专门的高成本设备 以及训练有素的人员，拥有超出大多数个人通常具备的专业知识 研究实验室。 UCD-SDRC 分子遗传分析核心的目标是为研究人员提供 拥有大规模和小规模、用户定义的基因分型所需的工具和专业知识 多态性遗传标记、大规模和小规模 DNA 测序以及全基因组、多基因和 单基因RNA表达分析。这些技术中的每一项都需要高成本的设备和 专业知识，UCD-SDRC 分子遗传分析核心将协调几个现有校园内的访问 拥有并运营所有这些技术所需设备的核心设施，以提供 与这些服务的无补贴成本相比，这些服务以折扣价向 UCD-SDCR 成员提供 这些核心实验室的服务或商业实体提供这些服务的成本。此外，UCD-SDRC 分子遗传分析核心将为研究人员提供遗传研究设计方面的专业知识，以便 优化利用宝贵的患者样本和资源，使研究人员能够回答重要的研究 皮肤病的问题。