Molecular Analysis, Modeling and Correction of Skin Diseases Core Center

皮肤病分子分析、建模与矫正核心中心

基本信息

批准号：
8740874
负责人：
DAVID A. NORRIS
金额：
$ 62.02万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8740874
关键词：
Address Advisory Committees Area Autoimmune Process Basic Science Biochemistry Biology Biomedical Engineering Cancer Grant Supplements (P30)Chairperson Clinical Clinical Research Clinical Trials Collaborations Colorado Cutaneous Dermatology Development Developmental Biology Disease Environment Epithelial Faculty Flow Cytometry Foundations Funding Gene Targeting Genetic Genetic Programming Genetic Skin Diseases Genomics Goals Grant Head Human Human Resources Immune Immunity Inflammation Inflammatory International Investments Laboratories Leadership Medical Medical Genetics Medical center Mentorship Metabolic Microbiology Modeling Molecular Molecular Analysis Molecular Genetics Molecular and Cellular Biology Morphology National Institute of Arthritis and Musculoskeletal and Skin Diseases Natural Immunity Paper Pharmacology Phenotype Process Publishing Regenerative Medicine Reporting Research Research Personnel Research Project Grants Research Support Role Science Scientist Series Services Site Skin Speed Stem cells Structure Suggestion Techniques Time Transgenic Organisms Translational Research Universities adaptive immunity animal model development appendage base carcinogenesis experience genetic analysis innovation interest keratinocyte differentiation melanocyte member new technology programs public health relevance research facility skin disorder stem cell biology success tissue repair virology

项目摘要

DESCRIPTION (provided by applicant): This is competing renewal of the SDRC "Molecular Analysis, Modeling and Correction of Skin Diseases Core Center". This is a broad based program on the University of Colorado Anschutz Medical Campus (UCAMC) with 56 members including 22 within the Department of Dermatology. Its goal is the correction of human skin diseases by molecular techniques. The first 4 years of this Center have been highly successful: SDRC investigators in collaborative projects or in P&F projects have added $20,371,611 in new research funding to the Institutional Research Base; The P&F program itself has shown a ~35-fold return on investment during the first 4 years. Collaborations within the SDRC have resulted in 71 published papers that were greatly supported by the Research Cores. The enrichment program and the management of collaborations have created a powerful collaborative network of investigators in skin disease related research. During the next 5 year period, we will add Xiao-Xing Wang to our leadership team of David Norris, Dennis Roop and Richard Spritz. We will retain 5 Cores (Administrative Core, Molecular Genetic Analysis Core, Bioengineering Core, Morphology and Phenotyping Core, and a Flow Cytometry Core), but the services offered will be altered and enhanced based on the experience of the first 4 years of funding, and on the suggestions of the Advisory Committee. The Enrichment Program will be greatly expanded by creating: A Global Skin Diseases Research Consortium to promote international research collaborations and speed the application of new science to exciting translational research projects A Mentorship Program "A New Technology Program to facilitate research within the UCAMC-SDRC and in the Global Consortium. Translational research using treatments developed by this SDRC will be greatly enhanced by addition of new members to the Clinical Investigations Team, and by the availability of a new GMP facility in close proximity to the SDRC member laboratories and clinical facilities on the AMC.

描述（由申请人提供）：这是SDRC“皮肤疾病分子分析、建模和校正核心中心”的竞争性更新。这是科罗拉多大学安舒茨医学校区 (UCAMC) 的一个基础广泛的项目，拥有 56 名成员，其中 22 名来自皮肤科。其目标是通过分子技术纠正人类皮肤疾病。该中心的前 4 年非常成功：SDRC 合作项目或 P&F 项目的研究人员为机构研究基地增加了 20,371,611 美元的新研究经费； P&F 计划本身在前 4 年就显示出约 35 倍的投资回报率。 SDRC 内部的合作已发表 71 篇论文，并得到了研究核心的大力支持。充实计划和合作管理创建了一个强大的皮肤病相关研究研究人员合作网络。在接下来的 5 年里，我们将把王晓星加入由 David Norris、Dennis Roop 和 Richard Spritz 组成的领导团队。我们将保留5个核心（管理核心、分子遗传分析核心、生物工程核心、形态学和表型分析核心以及流式细胞术核心），但所提供的服务将根据前4年资助的经验进行改变和增强，以及咨询委员会的建议。通过创建以下内容，丰富计划将得到极大扩展：全球皮肤病研究联盟，以促进国际研究合作并加快新科学在激动人心的转化研究项目中的应用导师计划 “一项新技术计划，以促进 UCAMC-SDRC 内的研究和通过在临床研究团队中增加新成员以及在 SDRC 成员实验室附近建立新的 GMP 设施，使用 SDRC 开发的治疗方法的转化研究将得到极大的加强。 AMC 的临床设施。