Genomics Core

基因组学核心

• 批准号: 8751098
• 负责人: Patrick M Gaffney
• 金额: $ 49.26万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8751098
• 关键词: Address; Architecture; Area; Autoimmune Diseases; Autoimmunity; Biological Assay; Biomedical Research; Businesses; Capital; Centers of Research Excellence; Clinical; Complex; Core Facility; Costs and Benefits; Coupled; DNA Sequence; Data; Data Set; Diagnostic tests; Emerging Technologies; Equipment; Experimental Designs; Fee-for-Service Plans; Funding; Future; Generations; Genetic; Genomics; Genotype; Grant; High-Throughput Nucleotide Sequencing; Human; Informatics; Investments; Laboratories; Lead; Medical; Molecular; Patients; Phase; Play; Quality Control; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science; Services; Stream; Technology; Testing; Vertebral column; cost; exome; genetic analysis; genome sequencing; innovation; instrument; programs; success

The first specific aim of this project is to provide COBRE Investigators and collaborators access to state of the art high throughput genetic analysis platforms, other sophisticated equipment, and experimental capabilities. Genetic discoveries and emerging technologies are radically changing biomedical research and the methods by which our COBRE investigators unravel the complex genomic architecture of autoimmune diseases. The Genomics Core serves as the central resource for COBRE investigators to access cuttingedge genomic technologies that allow their research programs to develop and test their hypotheses, therefore, the Genomics Core is highly significant and vital to the success of our Center investigators. The second specific aim of this project is to transition the Genomics Core from a COBRE-subsidized facility to a self-sustaining business entity supported by users both internal to OMRF as well as external. The capabilities of the Genomics Core make it particularly attractive to those researchers planning research projects that incorporate genomics. As such, researchers have utilized and can be expected to continue utilizing the Core as a simple fee-for-service unit or in a sub-contractual setting in funded grants. With our services in high demand from both COBRE and external investigators, the Core is poised to pursue multiple lines of funding through various mechanisms in our move towards overall financial self-sufficiency in Phase III. Furthermore, with the embrace of exome and whole genome sequencing of human patients, the Core could expand its local impact and open an entirely new revenue stream by providing medical diagnostic tests in addition to our central focus of supporting research. It is anticipated that the expansion into clinical genomics, coupled with increasing grant support from other mechanisms, will lead to the Core becoming completely self-sufficient at the end of 5 years.

该项目的第一个具体目标是为 COBRE 调查人员和合作者提供了解 最先进的高通量遗传分析平台、其他精密设备和实验 能力。基因发现和新兴技术正在从根本上改变生物医学研究和 我们的 COBRE 研究人员揭示自身免疫复杂基因组结构的方法 疾病。 Genomics Core 是 COBRE 研究人员获取尖端技术的中心资源 基因组技术使他们的研究项目能够发展和测试他们的假设， 因此，基因组学核心对于我们中心研究人员的成功至关重要。 该项目的第二个具体目标是将基因组学核心从 COBRE 补贴的设施转变为 一个由 OMRF 内部和外部用户支持的自我维持的业务实体。这 基因组学核心的功能使其对计划研究的研究人员特别有吸引力 结合基因组学的项目。因此，研究人员已经利用并有望继续 将核心用作简单的按服务收费单位或在资助赠款的分包合同环境中使用。与我们的 COBRE 和外部调查员对服务的需求很高，核心准备寻求多种服务 通过各种机制提供资金，帮助我们逐步实现财务自给自足 三．此外，随着人类患者外显子组和全基因组测序的采用，核心 可以通过提供医疗诊断测试扩大其当地影响并开辟全新的收入来源 除了我们支持研究的中心重点之外。预计将扩展到临床 基因组学，加上其他机制不断增加的资助支持，将导致核心成为 5年后完全自给自足。