Molecular Mechanisms and Genetics of Autoimmunity COBRE

自身免疫 COBRE 的分子机制和遗传学

• 批准号: 8902227
• 负责人: Patrick M Gaffney
• 金额: $ 124.21万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8902227
• 关键词: Molecular; Mechanisms; Genetics; Autoimmunity; COBRE

DESCRIPTION (provided by applicant): The Oklahoma Medical Research Foundation's ten-year COBRE, "Molecular Mechanisms and Genetics of Autoimmunity (GM 103456) has been transformative in providing the foundation for growth in understanding the molecular and genetic basis of autoimmune diseases in our state. This COBRE provided mentoring, funding and infrastructure support to launch multiple independent research careers and the awarding of "non-COBRE" program or center grants, greatly expanding the research base in Oklahoma. OMRF and Oklahoma can now legitimately claim to be a "Center" for Autoimmunity Genetics and Genomics in the United States. We now propose to develop to financial and operational independence two key research cores that were instrumental in our previous success. The Genomics core (formerly the Nucleic Acids Core) has been a component of this COBRE since it's beginning. Now equipped with next generation sequencing and high-throughput genotyping capability, this core generates the genomic data needed for the research projects of over 40 users. The Quantitative Analysis Core (QAC) was formed in year 10 through a merger of two existing cores, one focusing on statistics and the other on bioinformatics. The QAC provides COBRE investigators with access to an integrated group of data analysts, statisticians and bioinformaticists offering a full range of support from study design, power estimates, statistical analysis, and high dimensional data modeling. In addition to the research cores our COBRE Phase III supports Pilot Program and Administrative Cores. The pilot project core will identify, support and mentor COBRE eligible junior scientists through one year pilot projects. We view these pilot funds as a fundamental to our plans for the future of our genomics research base in Oklahoma. The Administrative core will provide administrative support to COBRE scientists, implement and expand multidisciplinary enrichment programs and evaluate the effectiveness of the pilot projects. OMRF will continue to partner with this COBRE through sustained and expanding support of salaries, capital equipment, laboratory space and faculty recruitment. We are confident that with Phase III COBRE support OMRF and Oklahoma will have an outstanding Genomics Center.

描述（由申请人提供）：俄克拉荷马州医学研究基金会的十年柯布雷，“自身免疫性的分子机制和遗传学（GM 103456）在理解我们州的自动免疫疾病的分子和遗传基础方面的基础是对我们州的分子和遗传基础的增长的转变，为我们的国家提供了培养和培养的培训。 “非近代”计划或俄克拉荷马州的研究基础大大扩大了俄克拉荷马州的研究基础。由于它已经开始。定量分析核心（QAC）是通过两个现有核心的合并在第10年形成的，一种侧重于统计，另一个侧重于生物信息学。 QAC为COBRE调查人员提供了一组综合数据分析师，统计学家和生物信息学家的访问，从研究设计，功率估计，统计分析和高维数据建模提供了全方位的支持。除研究核心外，我们的III阶段还支持试点计划和行政核心。飞行员项目核心将通过一年的试点项目来识别，支持和指导毛co的初级科学家。我们认为这些试点资金是我们俄克拉荷马州基因组研究基础未来计划的基础。行政核心将为毛科学家提供行政支持，实施和扩展多学科的丰富计划，并评估试点项目的有效性。 OMRF将通过持续和扩大对工资，资本设备，实验室空间和教职员工招聘的支持和扩大的支持继续与这家毛豆合作。我们有信心，借助III阶段的COBRE支持OMRF和俄克拉荷马州将拥有出色的基因组中心。