Molecular Mechanisms and Genetics of Autoimmunity COBRE

自身免疫 COBRE 的分子机制和遗传学

• 批准号: 8712643
• 负责人: Patrick M Gaffney
• 金额: $ 125.87万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712643
• 关键词: Autoimmune Diseases; Autoimmunity; Award; Bioinformatics; Capital; Centers of Research Excellence; Core Facility; Data; Effectiveness; Equipment; Faculty; Foundations; Funding; Future; Genetic; Genomics; Genotype; Grant; Growth; Investments; Laboratories; Medical Research; Mentors; Molecular; Molecular Genetics; Nucleic Acids; Oklahoma; Phase; Pilot Projects; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Scientist; United States; Wages; base; career; data modeling; multidisciplinary; next generation sequencing; programs; public health relevance; statistics; success

DESCRIPTION (provided by applicant): The Oklahoma Medical Research Foundation's ten-year COBRE, "Molecular Mechanisms and Genetics of Autoimmunity (GM 103456) has been transformative in providing the foundation for growth in understanding the molecular and genetic basis of autoimmune diseases in our state. This COBRE provided mentoring, funding and infrastructure support to launch multiple independent research careers and the awarding of "non-COBRE" program or center grants, greatly expanding the research base in Oklahoma. OMRF and Oklahoma can now legitimately claim to be a "Center" for Autoimmunity Genetics and Genomics in the United States. We now propose to develop to financial and operational independence two key research cores that were instrumental in our previous success. The Genomics core (formerly the Nucleic Acids Core) has been a component of this COBRE since it's beginning. Now equipped with next generation sequencing and high-throughput genotyping capability, this core generates the genomic data needed for the research projects of over 40 users. The Quantitative Analysis Core (QAC) was formed in year 10 through a merger of two existing cores, one focusing on statistics and the other on bioinformatics. The QAC provides COBRE investigators with access to an integrated group of data analysts, statisticians and bioinformaticists offering a full range of support from study design, power estimates, statistical analysis, and high dimensional data modeling. In addition to the research cores our COBRE Phase III supports Pilot Program and Administrative Cores. The pilot project core will identify, support and mentor COBRE eligible junior scientists through one year pilot projects. We view these pilot funds as a fundamental to our plans for the future of our genomics research base in Oklahoma. The Administrative core will provide administrative support to COBRE scientists, implement and expand multidisciplinary enrichment programs and evaluate the effectiveness of the pilot projects. OMRF will continue to partner with this COBRE through sustained and expanding support of salaries, capital equipment, laboratory space and faculty recruitment. We are confident that with Phase III COBRE support OMRF and Oklahoma will have an outstanding Genomics Center.

描述（由申请人提供）：俄克拉荷马州医学研究基金会的十年 COBRE，“自身免疫的分子机制和遗传学 (GM 103456) 具有变革性，为理解我们州自身免疫性疾病的分子和遗传基础提供了基础该 COBRE 提供了指导、资金和基础设施支持，以启动多个独立研究职业并授予“非 COBRE”计划或中心资助，极大地扩展了。俄克拉荷马州的研究基地现在可以合法地声称自己是美国自身免疫遗传学和基因组学的“中心”。我们现在提议发展两个关键的研究核心，这两个核心研究中心对我们之前的成功发挥了重要作用。基因组学核心（以前称为核酸核心）自成立以来一直是该 COBRE 的组成部分，现在配备了下一代测序和高通量基因分型功能，该核心可生成所需的基因组数据。用于 40 多个用户的研究项目。定量分析核心 (QAC) 于第 10 年通过两个现有核心的合并而成立，一个专注于统计学，另一个专注于生物信息学。 QAC 为 COBRE 研究人员提供了一个由数据分析师、统计学家和生物信息学家组成的综合小组，提供从研究设计、功效估计、统计分析和高维数据建模等全方位的支持。除了研究核心之外，我们的 COBRE 第三阶段还支持试点计划和管理核心。试点项目核心将通过为期一年的试点项目来识别、支持和指导 COBRE 合格的初级科学家。我们将这些试点资金视为我们俄克拉荷马州基因组学研究基地未来计划的基础。行政核心将为 COBRE 科学家提供行政支持，实施和扩大多学科丰富计划，并评估试点项目的有效性。 OMRF 将继续与 COBRE 合作，在薪资、资本设备、实验室空间和教师招聘方面提供持续和扩大的支持。我们相信，凭借第三阶段 COBRE 的支持，OMRF 和俄克拉荷马州将拥有一个出色的基因组学中心。