Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia

失语症句子产生障碍的神经认知机制

• 批准号: 10735595
• 负责人: Yasmeen Faroqi Shah
• 金额: $ 62.39万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735595
• 关键词: Address; Agrammatism; Anatomy; Aphasia; Architecture; Area; Brain region; Broca Aphasia; Chronic; Clinical effectiveness; Communication; Communication impairment; Data; Development; Diagnosis; Dimensions; Disease; Elderly; Electromyography; Foundations; Goals; Impairment; Individual; Inferior frontal gyrus; Intervention; Language; Language Disorders; Left; Lesion; Linguistics; Magnetoencephalography; Measurement; Modeling; Morphology; National Institute on Deafness and Other Communication Disorders; Nerve Degeneration; Neuroanatomy; Neurocognitive; Occupations; Outcome; Participant; Personal Communication; Persons; Prevention; Process; Production; Public Health; Quality of life; Research; Research Proposals; Retrieval; Semantics; Specific qualifier value; Speech; Speed; Stroke; Symptoms; Testing; Time; Variant; Work; cognitive process; comorbidity; disability; improved; innovation; language impairment; lexical; neural; neural model; neuromechanism; neurophysiology; novel; post intervention; post stroke; programs; spatiotemporal; stroke survivor; stroke-induced aphasia; symptom cluster; syntax; theories

PROJECT SUMMARY Post-stroke agrammatic aphasia (PSA-G) is characterized by a cluster of symptoms (fragmented sentences, errors in functional morphology, a dearth of verbs, and slow speech rate), yet extant theories and language interventions focus on individual symptoms. This single-symptom theoretical and intervention focus results in limited gains in functional communication. The long-term goal of this research is to improve the clinical effectiveness of interventions for PSA-G. As a first step towards this goal, this project’s objective is to advance the theoretical framework of PSA-G by addressing two critical gaps. The first gap is in the mechanistic understanding of how lexical, grammatical, motoric, and cognitive processes work together to enable fluent sentence production and how this breaks down in PSA-G. The second gap is in the understanding of neural mechanisms underlying how sentence production planning normally unfolds over time and what crucial spatiotemporal alterations give rise to PSA-G versus other variants of post-stroke aphasia with predominantly lexico-semantic deficits (PSA-LS). The central hypothesis is that agrammatic language production results from spatiotemporal alterations in the neural dynamics of morphosyntactic and phonomotor processes, causing a cumulative processing bottleneck at the point of articulatory planning. This Synergistic Processing Bottleneck Model of Agrammatism will be tested with two specific aims. Specific Aim 1 will elucidate the relative contribution of syntactic and non-syntactic processes towards sentence production in aphasia by using speed metrics and a path modeling framework. The expected outcomes of this aim are an improved understanding of the extent to which delays in different linguistic processes underlying the agrammatic symptom cluster impair fluent sentence production in aphasia generally, and in PSA-G versus PSA-LS more specifically. Specific Aim 2 will determine the neural mechanisms underlying sentence production across language deficit profiles. Magnetoencephalography (MEG) will be used to compare alterations in timecourse and functional connectivity of key perilesional and contralesional syntactic hubs across increasingly demanding morphosyntactic production tasks. The expected outcome of this aim is a spatiotemporally specified neural model of sentence production in neurotypical, PSA-G, and PSA-LS speakers. The significance this research is that it will forward an empirically established multidimensional model of sentence production, which will lay the foundation for developing more targeted and effective language interventions for agrammatic aphasia. It will also contribute to a better understanding of agrammatism in neurodegenerative aphasias. The innovative aspects of this project include: a novel multidimensional theoretical framework that incorporates non-syntactic dimensions of phonomotor planning, processing capacity and speed, and neurophysiological dynamics; direct comparisons between PSA- G and PSA-LS groups; and MEG analysis of spoken language with simultaneous electromyographic measurement.

项目摘要 中风后的农业失语症（PSA-G）的特征是一组符号（零散的句子， 功能形态的错误，动词的死亡和言语速度缓慢），但非凡的理论和语言 干预措施的重点是个人症状。这种单个症状理论和干预重点导致 功能通信的收益有限。这项研究的长期目标是改善临床 PSA-G的干预措施的有效性。作为实现这一目标的第一步，该项目的目标是促进 PSA-G的理论框架通过解决两个关键差距。第一个差距在机械中 了解词汇，语法，室内和认知过程如何共同起作用以使流利 句子产生以及如何在PSA-G中分解。第二个差距是对中性的理解 句子生产计划通常如何随着时间的推移以及哪些关键的方式进行的机制 时空变化引起PSA-G与其他势后失语症的其他变体，主要产生 词典 - 弹性定义（PSA-LS）。中心假设是分析语言产生是由 形态同步和义能过程的神经动力学的时空改变，导致 累积加工瓶颈在发音计划时。这种协同处理瓶颈 农业性模型将以两个特定的目的进行测试。特定的目标1将阐明相对贡献 通过使用速度指标和一个 路径建模框架。这个目标的预期结果是对 延误了农业症状群集的不同语言过程，损害了流利的句子 通常在APHOSIA中的生产，PSA-G与PSA-LS中的生产更具体地。具体目标2将决定 跨语言赤字概况的句子产生的神经机制。 磁脑摄影（MEG）将用于比较时间和功能连接的变化 越来越苛刻的形态同步产生的关键周期和违反句法集线器 任务。该目标的预期结果是在空间指定的句子产生神经模型 神经型，PSA-G和PSA-LS扬声器。这项研究的意义是它将从经验上转发 建立的句子生产的多维模型，这将为发展更多 针对农业失语症的有针对性且有效的语言干预措施。它也将有助于更好 了解神经退行性失语症中的农业主义。该项目的创新方面包括： 新型的多维理论框架，结合了光态的非句法维度 计划，处理能力和速度以及神经生理动力学； PSA-的直接比较 G和PSA-LS组；以及简单肌电图的口语分析 测量。