INIA: Bioinformatics Core

INIA：生物信息学核心

基本信息

批准号：
8601916
负责人：
ROBERT W. WILLIAMS
金额：
$ 19.04万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-20 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8601916
关键词：
Alcoholism Alcohols Animal Model Archives Atlases Award Bioinformatics Brain Candidate Disease Gene ChIP-seq Custom Data Data Display Data Set Databases Documentation Education and Outreach Environment Exons Eye Galaxy Gene Expression Genes Genetic Genome Genomics Goals Grant Hippocampus (Brain)Housing Human Indiana Informatics Laboratories Learning Macaca Methods Monkeys Monoclonal Antibody R24 Mus National Institute on Alcohol Abuse and Alcoholism Neurosciences Online Systems Pathway Analysis Pathway interactions Phenotype Population Group Prevention Process Publishing Research Research Personnel Resources Risk Rodent Secure Services System Tissues Training Training Support Translations United States National Institutes of Health Weight Whole-Genome Shotgun Sequencing Work alcoholism therapy cohort data integration drinking genome sequencing information framework innovation member next generation next generation sequencing nonhuman primate programs public health relevance success tool transcriptome sequencing web services

项目摘要

DESCRIPTION (provided by applicant): A key objective of the INIA programs is to transform research on causes, prevention, and treatment of alcoholism. Integration of data sets and analytic methods across a broad spectrum of research is critical to success. This INIA UOI Core application is built on the success of several powerful INIA web services and data resources, including GeneNetwork, WebGestalt, and the Ontological Discovery Environment (ODE). However, our aims in this renewal are a direct outgrowth of rapid changes in genomics and neuroscience, in particular, next-generation sequencing. A theme of this core is innovation by integration. The far more pervasive use of web services in neuroscience over the last five years - Allen Brain Atlas, DAVID, ODE, Galaxy, GeneNetwork, GeneWiki, KEGG, and the Neuroscience Information Framework - represents a great research opportunity for our INIA teams. But these resources often have a steep learning curve and are difficult to use together. One of our goals is to assemble these resources together with large new data sets in a context useful to NIAAA researchers. The INIA Translational Web Services core has these aims: (1) Process, analyze, and distribute massive array and next-generation data sets for both INIA consortia; (2) Integrate INIA consortia data sets from rodents, non-human primates, and humans into GeneNetwork and significantly enhance tools for bidirectional translational queries; (3) Provide database support, training, and documentation in bioinformatics, genetics, and next-gen genomic tools to other INIA projects and cores.

描述（由申请人提供）：INIA计划的关键目标是改变对酗酒的原因，预防和治疗的研究。广泛研究中数据集和分析方法的整合对于成功至关重要。该INIA UOI核心应用程序建立在几种强大的INIA Web服务和数据资源的成功之上，包括GenEnetwork，Webgestalt和本体论发现环境（ODE）。但是，我们在这种更新中的目标是基因组学和神经科学的快速变化的直接产物，尤其是下一代测序。该核心的主题是通过集成创新。在过去的五年中，在神经科学中更普遍地使用Web服务 - 艾伦·脑图集，大卫，奥德，银河系，Genenetwork，Genewiki，Genewiki，Kegg和Neuroscience信息框架 - 代表了我们INIA团队的绝佳研究机会。但是这些资源通常具有陡峭的学习曲线，很难一起使用。我们的目标之一是在对NIAAA研究人员有用的上下文中组装这些资源以及大型新数据集。 INIA Translational Web Services Core具有以下目的：（1）为两个INIA财团的过程，分析和分发大量的数组和下一代数据集；（2）将来自啮齿动物，非人类灵长类动物和人类的INIA联盟数据集整合到GenEnetwork中，并显着增强了双向翻译查询的工具；（3）向其他INIA项目和核心提供生物信息学，遗传学和下一代基因组工具的数据库支持，培训和文档。