Administrative Core

行政核心

基本信息

批准号：
10848509
负责人：
BARBARA J MASON
金额：
$ 10万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-20 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10848509
关键词：
Abstinence Advisory Committees Alcoholism Alcohols Amygdaloid structure Animal Model Attention Behavioral Biochemical Biological Assay Budgets Cells Cellular Neurobiology Charge Collaborations Communities Community Outreach Data Dependence Ensure Expenditure Faculty Familiarity Fostering Funding Future Goals Grant Guidelines Health Personnel Healthcare Heavy Drinking Internships Lead Leadership Maps Medial Methods Molecular Monitor Neurobiology Neuroimmune Neuropharmacology Neurosciences Outcome Postdoctoral Fellow Preclinical Testing Procedures Proteomics Publications Recommendation Relapse Research Research Institute Research Personnel Resources Review Committee Role Science Scientist Series Services Standardization Stress Techniques Underrepresented Minority United States National Institutes of Health Youth alcohol effect alcohol research alcohol use disorder archived data cost effective data archive equity, diversity, and inclusion experience health disparity high risk interest lecturer meetings neural circuit neurophysiology neuroproteomics next generation operation outreach posters programs social media success vapor web site

项目摘要

Abstract Administrative Core The Administrative Core of The Scripps Research Institute-Alcohol Research Center (TSRI-ARC) provides leadership and an organizational framework to meet the Center’s Specific Aims. Center-wide scientific aims in the renewal are focused on the cellular and molecular mechanisms that modulate top-down medial prefrontal control of the central amygdala and underlie stress-induced vulnerability to relapse and excessive drinking during protracted abstinence. The Administrative Core facilitates Center-wide direction, oversight, and integration across 5 Research Components (Functional Connectomics, Neuropharmacology, Molecular, Neurophysiology, and Neurocircuitry), and 3 Cores (Dissemination, Animal Models, and Neuroproteomics). Specific Aims are: (1) Provide scientific and administrative leadership for TSRI-ARC Cores and Research Components to function in an optimal and synergistic manner. The Center Director chairs monthly meetings of the Steering Committee which is comprised of all Project Leads, and with the help of the Scientific Director and Deputy Scientific Director, monitors progress and outcomes of all projects, develops new collaborations, and identifies problems and proposes fair solutions. A Program Advisory Committee comprised of five external experts in domains relevant to TSRI-ARC will meet annually to review progress and make recommendations to the Director. The Director implements course corrections and the reprioritization of resources when indicated, and dynamically manages expenditures to bolster TSRI-ARC aims. (2) Facilitate the dissemination of expertise between Cores and Research Components and the utilization of Core resources. Cores provide systematic prioritization of resources and standardized methods that foster integration of projects. Rapid dissemination and utilization of Core expertise (e.g., new animal models, biochemical analyses, single-cell proteomics analysis techniques, and functional neurocircuitry mapping techniques) are accomplished by monthly Steering Committee meetings and monthly Center-at-Large scientific seminars. Requests for Core services are submitted (and data archived) on the TSRI-ARC website, providing transparency of Core operations and facilitating ongoing review of the Cores’ efficiency by the Steering Committee. (3) Provide scientific enrichment for TSRI-ARC and disseminate TSRI-ARC research. The Administrative Core will organize monthly scientific seminars to stimulate collaborations and scientific enrichment throughout the Center-at-Large. Seminars include a presentation by a project Lead on recent progress, or an invited lecturer on research relevant to TSRI-ARC’s scientific interests, in tandem with 1:1 meetings with investigators. TSRI-ARC will host an annual Scientific Retreat on the TSRI campus, consisting of a poster session, a data blitz, and presentations by TSRI-ARC and Center-at-Large investigators, T32 postdoctoral trainees, and interns. TSRI-ARC discoveries are shared with scientific, healthcare and lay stakeholders via scientific publications and presentations, our website and social media, and outreach to youth from health disparities backgrounds who are at higher risk for stress and AUD.

抽象行政核心斯克里普斯研究所酒精研究中心 (TSRI-ARC) 的行政核心提供领导和组织框架，以实现中心的具体目标。更新的重点是自上而下调节内侧前额叶的细胞和分子机制中央杏仁核的控制，是压力引起的复发和过度饮酒的脆弱性的基础行政核心促进中心范围内的指导、监督和整合。跨越 5 个研究组成部分（功能连接组学、神经药理学、分子、神经生理学、和神经电路），3 个核心（传播、动物模型和神经蛋白质组学）是：(1)。为 TSRI-ARC 核心和研究组件提供科学和行政领导，中心主任每月主持指导委员会会议。委员会由所有项目负责人组成，并在科学主任和副主任的帮助下科学总监，监督所有项目的进展和结果，开发新的合作，并确定项目咨询委员会由五名外部专家组成，并提出公平的解决方案。与 TSRI-ARC 相关的领域将每年召开一次会议，审查进展并向主任提出建议。主管根据指示实施路线修正并重新调整资源的优先顺序，并动态地 (2) 促进专业知识的传播核心和研究组件以及核心资源的利用提供了系统性。促进项目整合的资源优先级和标准化方法。利用核心专业知识（例如新动物模型、生化分析、单细胞蛋白质组学分析技术和功能神经回路映射技术）由每月指导委员会完成提交核心服务请求（和数据）。存档）在 TSRI-ARC 网站上，提供核心运营的透明度并促进持续审查指导委员会评估核心的效率 (3) 为 TSRI-ARC 提供科学丰富和传播 TSRI-ARC 研究成果。行政核心将每月组织一次科学研讨会，以传播 TSRI-ARC 研究成果。促进整个中心的合作和科学丰富研讨会包括：由项目负责人介绍最新进展，或邀请讲师进行与 TSRI-ARC 相关的研究科学兴趣，同时与研究人员进行一对一会议，TSRI-ARC 将举办年度科学会议。 TSRI 校园静修会，包括海报会议、数据闪电战以及 TSRI-ARC 和与 TSRI-ARC 的一般研究人员、T32 博士后实习生和实习生共享发现。通过科学出版物和演示、我们的网站和社交媒体，科学、医疗保健和非专业利益相关者媒体，以及对来自健康差异背景、压力和澳元风险较高的青少年的宣传。