Administrative Core NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome

行政核心 NIDA 转录组学、系统遗传学和成瘾组核心“卓越中心”

基本信息

批准号：
10177979
负责人：
ROBERT W. WILLIAMS
金额：
$ 9.44万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10177979
关键词：
Animal Model Archives Biology Biometry Chromosome Mapping Code Collaborations Communities Complex Conflict (Psychology)Consult DNA Data Data Set Development Diagnosis Disease Documentation Drug Addiction Drug Modelings Drug abuse Education and Outreach Educational workshop Environment Environmental Risk Factor Epigenetic Process Family Genetic Genome Genomics Genotype-Tissue Expression Project Goals Grant Hybrids Informatics Institution Internet Leadership Libraries Machine Learning Mass Spectrum Analysis Mathematics Metadata Metagenomics Methods Modeling Molecular Multiomic Data National Institute of Drug Abuse National Institute on Alcohol Abuse and Alcoholism Participant Pharmaceutical Preparations Pharmacotherapy Postdoctoral Fellow Prevention Proteome Protocols documentation Publications RNA Rat Genome Database Rattus Records Relapse Reporting Reproducibility Research Research Personnel Research Support Resources Risk Risk Factors Rodent Running Science Services Stress Students Sum System Testing Training Training Programs Treatment outcome United States National Institutes of Health Vertebral column Visit Western Blotting Work addiction behavior influence behavioral study brain cell cohort data sharing drug relapse epigenome expectation experimental study genetic variant improved innovation machine learning method meetings member metabolome neuronal circuitry online resource outreach program patch sequencing phenome precision medicine prevent programs ranpirnase sex software systems transcriptome transcriptome sequencing transcriptomics vector webinar

项目摘要

Addiction is a highly complex disease with risk factors that include genetic variants and differences in development, sex, and environment. The long term potential of precision medicine to improve drug treatment and prevention depends on gaining a much better understanding how genetics, drugs, brain cells, and neuronal circuitry interact to influence behavior. There are serious technical barriers that prevent researchers and clinicians from incorporating more powerful computational and predictive methods in addiction research. The purpose of the NIDA P30 Core Center of Excellence in Omics, Systems Genetics, and the Addictome is to empower and train researchers supported by NIH, NIDA, NIAAA, and other federal and state institutions to use more quantitative and testable ways to analyze genetic, epigenetic, and the environmental factors that influence drug abuse risk and treatment. The Administrative Core manages relations among research cores, groups of users, trainees, and pilot program participants. The Transcriptome Informatics and Mechanisms research core assembles and analyzes hundreds of large genome (DNA) and transcriptome (RNA) datasets for experimental rodent (rat) models of addiction. The Systems Analytics and Modeling research core, is using innovative systems genetics methods (gene mapping) to understand the linkage between DNA differences, environmental risks such as stress, and the differential risk of drug abuse and relapse. The Pilot core is catalyzing new collaborations among young investigator in the field of addiction research. In sum the Center is a national resource for more reproducible research in addiction. We are centralizing, archiving, distributing, analyzing and integrating high quality data, metadata, using open software systems in collaboration with many other teams of researchers. Our goal is to help build toward an NIDA Addictome Portal that will include all genomic research relevant to addiction research.

成瘾是一种高度复杂的疾病，危险因素包括遗传变异和差异发展，性别和环境。精确医学改善药物治疗的长期潜力预防取决于获得更好地了解遗传学，药物，脑细胞和神经元电路相互作用以影响行为。有严重的技术障碍可以阻止研究人员以及将更强大的计算和预测方法纳入成瘾研究中的临床医生。 NIDA P30 OMICS，系统遗传学和上瘾的核心核心核心核心中心的目的是为NIH，NIDA，NIAAA和其他联邦和州机构提供支持的研究人员的能力和培训使用更多定量和可检验的方法来分析遗传，表观遗传学和环境因素影响滥用药物的风险和治疗。行政核心管理研究核心之间的关系，一组用户，受训者和试点计划参与者。转录组信息学和机制研究核心组装并分析数百个大基因组（DNA）和转录组（RNA）数据集用于成瘾的实验啮齿动物（大鼠）模型。系统分析和建模研究核心正在使用创新的系统遗传学方法（基因映射）以了解DNA差异之间的联系，压力等环境风险以及药物滥用和复发的差异风险。飞行员核心是催化成瘾研究领域的年轻研究者之间的新合作。总之，中心是用于成瘾中更多可再现研究的国家资源。我们正在集中，存档，分发，分析和集成高质量数据，元数据，使用开放软件系统与许多其他研究人员团队。我们的目标是帮助建立NIDA成瘾的门户，其中包括所有与成瘾研究有关的基因组研究。