INIA: Bioinformatics Core

INIA：生物信息学核心

基本信息

批准号：
8727145
负责人：
ROBERT W. WILLIAMS
金额：
$ 1.8万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-20 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8727145
关键词：
Alcoholism Alcohols Animal Model Archives Atlases Award Bioinformatics Brain Candidate Disease Gene ChIP-seq Custom Data Data Display Data Set Databases Documentation Education and Outreach Environment Exons Eye Galaxy Gene Expression Genes Genetic Genome Genomics Goals Grant Hippocampus (Brain)Housing Human Indiana Informatics Laboratories Learning Macaca Methods Monkeys Monoclonal Antibody R24 Mus National Institute on Alcohol Abuse and Alcoholism Neurosciences Online Systems Pathway Analysis Pathway interactions Phenotype Population Group Prevention Process Publishing Research Research Personnel Resources Risk Rodent Secure Services System Tissues Training Training Support Translations United States National Institutes of Health Weight Whole-Genome Shotgun Sequencing Work alcoholism therapy cohort data integration drinking genome sequencing information framework innovation member next generation next generation sequencing nonhuman primate programs success tool transcriptome sequencing web services

项目摘要

DESCRIPTION (provided by applicant): A key objective of the INIA programs is to transform research on causes, prevention, and treatment of alcoholism. Integration of data sets and analytic methods across a broad spectrum of research is critical to success. This INIA UOI Core application is built on the success of several powerful INIA web services and data resources, including GeneNetwork, WebGestalt, and the Ontological Discovery Environment (ODE). However, our aims in this renewal are a direct outgrowth of rapid changes in genomics and neuroscience, in particular, next-generation sequencing. A theme of this core is innovation by integration. The far more pervasive use of web services in neuroscience over the last five years - Allen Brain Atlas, DAVID, ODE, Galaxy, GeneNetwork, GeneWiki, KEGG, and the Neuroscience Information Framework - represents a great research opportunity for our INIA teams. But these resources often have a steep learning curve and are difficult to use together. One of our goals is to assemble these resources together with large new data sets in a context useful to NIAAA researchers. The INIA Translational Web Services core has these aims: (1) Process, analyze, and distribute massive array and next-generation data sets for both INIA consortia; (2) Integrate INIA consortia data sets from rodents, non-human primates, and humans into GeneNetwork and significantly enhance tools for bidirectional translational queries; (3) Provide database support, training, and documentation in bioinformatics, genetics, and next-gen genomic tools to other INIA projects and cores.

描述（由申请人提供）：INIA 计划的一个关键目标是转变对酒精中毒的原因、预防和治疗的研究。跨广泛研究的数据集和分析方法的整合对于成功至关重要。该 INIA UOI 核心应用程序建立在多个强大的 INIA Web 服务和数据资源的成功之上，包括 GeneNetwork、WebGestalt 和本体发现环境 (ODE)。然而，我们这次更新的目标是基因组学和神经科学（特别是下一代测序）快速变化的直接产物。该核心的主题是整合创新。过去五年，网络服务在神经科学领域的使用更加普遍——Allen Brain Atlas、DAVID、ODE、Galaxy、GeneNetwork、GeneWiki、KEGG 和神经科学信息框架——为我们的 INIA 团队提供了绝佳的研究机会。但这些资源通常具有陡峭的学习曲线并且难以一起使用。我们的目标之一是在对 NIAAA 研究人员有用的环境中将这些资源与大型新数据集整合在一起。 INIA Translational Web Services 核心具有以下目标： (1) 为 INIA 联盟处理、分析和分发海量数组和下一代数据集； (2) 将来自啮齿动物、非人类灵长类动物和人类的 INIA 联盟数据集集成到 GeneNetwork 中，并显着增强双向翻译查询工具； (3) 为其他 INIA 项目和核心提供生物信息学、遗传学和下一代基因组工具的数据库支持、培训和文档。