Pilot Research Project Core NIDA "COE" Transcriptomics, Systems Genetics and the Addictome

试点研究项目核心 NIDA“COE”转录组学、系统遗传学和成瘾组

基本信息

批准号：
10177982
负责人：
ROBERT W. WILLIAMS
金额：
$ 2.78万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10177982
关键词：
Applications Grants Archives Biological Models Collaborations Communities Complex Data Development Disease Drug abuse Educational workshop Ensure Environment Environmental Risk Factor Epigenetic Process Equipment Faculty Feedback Funding Generations Genetic Genetic Variation Genomics Goals Grant Hybrids Informatics Institution Laboratories Lead Letters Metadata Methods Modeling National Institute of Drug Abuse National Institute on Alcohol Abuse and Alcoholism Pharmaceutical Preparations Pharmacotherapy Pilot Projects Prevention Proteomics Publications Rat Strains Rattus Recruitment Activity Reproducibility Research Research Design Research Personnel Research Project Grants Resources Risk Risk Factors Role Running Sum System Systems Analysis Systems Biology Technology Testing Tissues Training United States National Institutes of Health Work addiction base behavior influence biobank brain cell career design follow-up genetic variant improved innovation meetings member metabolomics multiple omics neuronal circuitry new technology novel precision medicine prevent programs ranpirnase relating to nervous system response sex single-cell RNA sequencing software systems success symposium transcriptome transcriptomics

项目摘要

Addiction is a highly complex disease with risk factors that include genetic variants and differences in development, sex, and environment. The long term potential of precision medicine to improve drug treatment and prevention depends on gaining a much better understanding how genetics, drugs, brain cells, and neuronal circuitry interact to influence behavior. There are serious technical barriers that prevent researchers and clinicians from incorporating more powerful computational and predictive methods in addiction research. The purpose of the NIDA P30 Core Center of Excellence in Omics, Systems Genetics, and the Addictome is to empower and train researchers supported by NIH, NIDA, NIAAA, and other federal and state institutions to use more quantitative and testable ways to analyze genetic, epigenetic, and the environmental factors that influence drug abuse risk and treatment. Our Pilot core is catalyzing new collaborations among early career investigators in the field of addiction research. In sum the Center is a national resource for reproducible research in addiction. We are centralizing, archiving, distributing, analyzing and integrating high quality data, metadata, using open software systems in collaboration with many other teams of researchers. Our goal is to help build toward an NIDA Addictome Portal that will include all genomic research relevant to addiction research.

成瘾是一种高度复杂的疾病，危险因素包括遗传变异和差异发展，性别和环境。精确医学改善药物治疗的长期潜力预防取决于获得更好地了解遗传学，药物，脑细胞和神经元电路相互作用以影响行为。有严重的技术障碍可以阻止研究人员以及将更强大的计算和预测方法纳入成瘾研究中的临床医生。 NIDA P30 OMICS，系统遗传学和上瘾的核心核心核心核心中心的目的是为NIH，NIDA，NIAAA和其他联邦和州机构提供支持的研究人员的能力和培训使用更多定量和可检验的方法来分析遗传，表观遗传学和环境因素影响滥用药物的风险和治疗。我们的飞行员核心正在促进早期职业的新合作成瘾研究领域的研究者。总而言之，该中心是可重现的国家资源成瘾研究。我们正在集中，存档，分发，分析和集成高质量的数据，元数据与许多其他研究人员团队合作使用开放软件系统。我们的目标是帮助NIDA成瘾的门户网站，其中包括所有与成瘾有关的基因组研究研究。