Eye Movement: Physiological Organization

眼球运动：生理组织

• 批准号: 8670368
• 负责人: ROBERT G BAKER
• 金额: $ 11.26万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8670368
• 关键词: Affect; Automobile Driving; Behavior; Behavior Control; Behavioral; Blood Circulation; C.I. Solvent Yellow 56; Calcium Signaling; Cell Nucleus; Cells; DNA; Development; Electrophysiology (science); Enhancers; Exhibits; Eye; Eye Movements; Fishes; Genes; Genetic; Grant; Growth; Image; Immunohistochemistry; In Situ Hybridization; Individual; Inferior; Injection of therapeutic agent; Label; Laboratories; Larva; Link; Location; Locomotion; Manuscripts; Measures; Microscopy; Morphology; Motor; Neuronal Differentiation; Neurons; Oculomotor nucleus; Oligonucleotides; Olives - dietary; Pathway interactions; Pattern; Phenotype; Physiological; Play; Population; Positioning Attribute; Preparation; Property; Proteins; Publications; RNA; Regulation; Regulator Genes; Regulatory Element; Reporter; Research; Research Personnel; Resolution; Role; Specimen; Structure; Swimming; System; Testing; Time; Torsion; Tracer; Transgenic Organisms; Tretinoin; Up-Regulation; Vascularization; Visual; Work; Zebrafish; cost; developmental genetics; eye velocity; hindbrain; immunocytochemistry; islet; loss of function; member; migration; neuron development; neuronal excitability; oculomotor; oculomotor behavior; paralogous gene; pleiotropism; programs; relating to nervous system; transcription factor; vocalization

Considerable progress was made in the first year of the no cost extension in publications that built on the grants 5 years of studying diverse hindbrain circuits and behaviors controlling eye movements, locomotion, swimming and vocalization in fish (see Publications). There were three major ongoing projects that likely would have been completed experimentally if not for Hurricaine Sandy and the closure of offices, laboratories and zebrafish facility. First, our extensive observations on the Hox 3 paralogs testing neuronal “pleiotropism” and “modularity” for horizontal and vertical eye movements were presented in a Nat Comm manuscript challenging current Hox gene dogma (currently in preparation for reviewer rebuttal) but the experimental work necessary for the rebuttal have been curtailed. Second, the role of neuronal excitability and/or endothelial vascularization along with circulation during the development of neurons, pathways and function was in the midst of being rigorously tested in motor behaviors that can be measured with high-resolution. Third, the ability to assign an exact role for an individual hox gene in determining the structure/function of a given neuronal phenotype was being assessed with corroborative behavioral and multiphoton calcium signaling. Each of these three major projects is summarized below along with their plans for completion.

在基于该出版物的出版物的第一年，取得了很大的进展 授予5年研究潜水的后脑回路和控制眼动，运动的行为， 鱼类游泳和发声（请参阅出版物）。有三个正在进行的主要项目可能 如果不是飓风桑迪和办公室，实验室的关闭，本来可以通过实验完成的 和斑马鱼设施。首先，我们对HOX 3旁系同源物测试神经元“多效性”的广泛观察结果 在NAT通讯手稿中介绍了水平和垂直眼动的“模块化” 挑战当前HOX基因教条（目前正在为审稿人反驳做准备），但实验性工作 反驳所必需的已被限制。第二，神经元令人兴奋和/或内皮的作用 在神经元，途径和功能发展过程中的血管化以及循环中 在可以通过高分辨率测量的运动行为中进行严格测试的中间。第三，能力 分配单个HOX基因确定给定神经元的结构/功能的确切作用 通过证实的行为和多光子钙信号传导评估表型。每个 下面总结了三个主要项目以及他们的完成计划。

项目成果

The pathways and functions of GABA in the oculomotor system.

GABA 在动眼神经系统中的通路和功能。

• DOI: 10.1016/s0079-6123(08)63620-1
• 发表时间: 1992
• 期刊: Progress in brain research
• 作者: Spencer,RF;Wang,SF;Baker,R
• 通讯作者: Baker,R

GABA and glycine as inhibitory neurotransmitters in the vestibuloocular reflex.

GABA 和甘氨酸作为前庭眼反射中的抑制性神经递质。

• DOI: 10.1111/j.1749-6632.1992.tb25239.x
• 发表时间: 1992
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Spencer,RF;Baker,R
• 通讯作者: Baker,R

Innervation of extraocular muscles in the rabbit.

兔子眼外肌的神经支配。

• DOI: 10.1002/cne.902540107
• 发表时间: 1986
• 期刊: The Journal of comparative neurology
• 作者: Murphy,EH;Garone,M;Tashayyod,D;Baker,RB
• 通讯作者: Baker,RB

Vestibular blueprint in early vertebrates.

早期脊椎动物的前庭蓝图。

• DOI: 10.3389/fncir.2013.00182
• 发表时间: 2013
• 期刊: Frontiers in neural circuits
• 影响因子: 3.5
• 作者: Straka,Hans;Baker,Robert
• 通讯作者: Baker,Robert

Changes in Refractive Error Under COVID-19: A 3-Year Follow-up Study.

• DOI: 10.1007/s12325-022-02150-0
• 发表时间: 2022-06
• 期刊: ADVANCES IN THERAPY
• 影响因子: 3.8
• 作者: Yang, Xiaoyan;Fan, Qian;Zhang, Yue;Chen, Xiaoqin;Jiang, Yanglin;Zou, Haohan;Li, Mengdi;Li, Lihua;Wang, Yan
• 通讯作者: Wang, Yan