EYE MOVEMENT--PHYSIOLOGICAL ORGANIZATION

眼球运动--生理组织

• 批准号: 6125163
• 负责人: ROBERT G BAKER
• 金额: $ 32.29万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-09-30 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6125163
• 关键词: alternatives to animals in research; axon; developmental genetics; developmental neurobiology; eye movements; fluorescent dye /probe; gene mutation; myogenesis; neural information processing; neurogenesis; oculomotor nerve; oculomotor nuclei; rhombencephalon; sensorimotor system; single cell analysis; vestibular nerve; vestibular pathway; visual pathways; visual stimulus; zebrafish

DESCRIPTION (Adapted from the Investigator's Abstract): Experiments are proposed which will utilize the physiological, developmental and genetic attributes of the zebrafish system to study vertebrate oculomoter function. The overall general hypothesis is that conserved genetic and anatomical profiles within segmented compartments of the hindbrain , called rhombomeres, are responsible for the phylogenetic conservation of oculomotor behaviors in vertebrates. Four specific aims are proposed to demonstrate the genetic basis of oculomotor function in the zebrafish with the expectation that these findings can be extrapolated to other vertebrates. The specific aims propose to describe the structure and function of visual and vestibular neurons along with circuits that control individual oculomotor behaviors as well as to establish the embryonic origin and genotype of each subgroup derived from the rhombomeres. Identification of oculomotor phenotypes within unique rhombomeric units will allow structural and behavioral analysis of relevant single gene mutations permitting assignment of single gene correlates to behavior.

描述（根据调查员的摘要改编）：实验是 提出的将利用生理，发育和遗传 斑马鱼系统的属性研究脊椎动物眼动函数。 总体一般假设是保守的遗传和解剖学 后脑的分段隔室中的轮廓，称为 菱形，负责动眼的系统发育保守性 脊椎动物中的行为。 提出了四个具体目标来证明 斑马鱼中动眼功能的遗传基础 期望这些发现可以推断到其他脊椎动物。 具体目的建议描述视觉的结构和功能 和前庭神经元以及控制个体的电路 动眼行为以及建立胚胎起源和 来自菱形的每个亚组的基因型。 识别 独特的菱形单元中的动眼表型将允许结构 以及相关的单基因突变的行为分析允许 单个基因的分配与行为相关。