Receptive Field Mosaics of Midget, Parasol and Small Bi-Stratified Ganglion Cells

侏儒、阳伞和小双层神经节细胞的感受野镶嵌

基本信息

批准号：
8733699
负责人：
EDUARDO CHICHILNISKY
金额：
$ 39.32万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-01 至 2016-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of our research is to understand visual signaling by the primate retina, and to exploit this knowledge in the treatment of blindness. The goal of the proposed work is to understand three fundamental aspects of visual signaling in the major ganglion cell types of the retina, which convey distinct visual signals to multiple targets in the brain. The specific aims are to explore (1) how the elementary signal for daylight vision, the activation of a single cone, propagates through parallel pathways to the distinct ganglion cell types; (2) the spatial structure and origin of nonlinear visual computations performed in the inner retinal circuitry; (3) the organization and function of polyaxonal amacrine cells which modulate visual signals in ganglion cells. To approach these problems, we will exploit our unique large-scale multi- electrode recordings from isolated primate retina to sample complete visual signals in the major 5 ganglion cell types (ON parasol, OFF parasol, ON midget, OFF midget, and small bistratified), which collectively constitute 75% of the visual representation. We will also extend this unique experimental approach with three novel techniques: independent stimulation of each of the cone photoreceptors over a large region of retina, advanced statistical analysis to uncover the spatial structure of nonlinear computations at the resolution of individual cones, and electrical imaging to record from several types of amacrine cells simultaneously with ganglion cells. At the completion of this work we hope to have a deeper understanding of how cone signals, transmitted through the parallel pathways, are combined, processed and modulated in the parallel circuits of the primate retina.

描述（由申请人提供）：我们研究的长期目标是了解灵长类动物视网膜的视觉信号，并利用这些知识来治疗失明。拟议的工作的目的是了解视网膜主要神经节细胞类型中视觉信号的三个基本方面，这些方面将不同的视觉信号传达给大脑中的多个目标。具体的目的是探索（1）如何通过平行途径传播到不同神经节细胞类型的日光视觉的基本信号，即单个锥体的激活；（2）在视网膜内部电路中执行的非线性视觉计算的空间结构和起源；（3）多轴心无链氨酸细胞的组织和功能调节神经节细胞中的视觉信号。为了解决这些问题，我们将利用我们独特的大型多电极记录从孤立的灵长类动物视网膜到主要5个神经节细胞类型的完全视觉信号（在Parasol，Off Parasol，parasol，in Midget，Midget，Midget和小型Bistratified）中，共同构成了视觉表示的75％。我们还将通过三种新型技术扩展这种独特的实验方法：在大型视网膜上对每个锥形光感受器的独立刺激，高级统计分析，以揭示单个锥体分辨率下非线性计算的空间结构，而电气成像以同时与神经节细胞同时进行amacrine细胞中记录。在完成这项工作时，我们希望更深入地了解如何在灵长类动物视网膜的平行电路中组合，处理和调节通过平行途径传输的锥体信号。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Reconstruction of natural images from responses of primate retinal ganglion cells.

DOI：
10.7554/elife.58516
发表时间：
2020-11-04
期刊：
eLife
影响因子：
7.7
作者：
Brackbill N;Rhoades C;Kling A;Shah NP;Sher A;Litke AM;Chichilnisky EJ
通讯作者：
Chichilnisky EJ

Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.

DOI：
10.1016/j.cub.2016.05.051
发表时间：
2016-08-08
期刊：
CURRENT BIOLOGY
影响因子：
9.2
作者：
Greschner, Martin;Heitman, Alexander K.;Field, Greg D.;Li, Peter H.;Ahn, Daniel;Sher, Alexander;Litke, Alan M.;Chichilnisky, E. J.
通讯作者：
Chichilnisky, E. J.