ALPHA CRYSTALLIN

阿尔法水晶蛋白

• 批准号: 8361109
• 负责人: Jonathan Alan King
• 金额: $ 1.23万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361109
• 关键词: Cells; Complex; Crying; Crystallins; Electron Microscopy; Funding; Grant; Lens Fiber; Molecular Chaperones; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; Structure; United States National Institutes of Health; alpha-Crystallins; beta-Crystallins; cost; fiber cell; gamma-Crystallins; lens; macromolecule; monomer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Alpha-crystallin, along with the beta- and gamma-crystallins, is one of the ubiquitous crystallins in vertebrate lenses. It is a major structural component of lens fiber cells and also has chaperone activity in these cells. In the lens, it is a hetero-oligomeric complex composed of two monomers ¿A- and ¿B-crystallin. We propose to use cry-EM to solve its structure.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供 该子项目的主要支持。 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源的子项目可能列出的总成本。 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 α-晶状体蛋白以及 β-和 γ-晶状体蛋白是普遍存在的一种 脊椎动物晶状体中的晶状体蛋白是晶状体纤维细胞的主要结构成分。 在这些细胞中具有伴侣活性，在晶状体中，它是由异源寡聚复合物组成。 两个单体的 ¿ A- 和 ¿我们建议使用cry-EM 来解析其结构。